The effects of naltrexone on neural responses to methamphetamine cues

Courtney, Kelly E.; Ghahremani, Dara G.; Ray, Lara A.

doi:10.1016/j.drugalcdep.2016.08.141

Cited by 1 publication

(1 citation statement)

References 269 publications

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“…Amphetaminetype stimulants are the most common abused substances after cannabis and compared to other substance use disorders, amphetamine use disorder constitutes a considerable piece of the global weight of disease [1]. The number of methamphetamine addicts and demand for the treatment of methamphetamine-related conditions is increasing in many parts of the world, including southwest Asia [1]; however, no proper pharmacological treatment has yet been approved by the Food and Drug Administration [2], and behavioral interventions, as the main rehabilitation for these patients [3], have been successful only to some extent [4].…”

Section: Introductionmentioning

confidence: 99%

Repeated Transcranial Direct Current Stimulation (tDCS) on Methamphetamine Craving: A Randomized, Sham-controlled Study

et al. 2019

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The modulation of the dorsolateral prefrontal cortex (DLPFC) activity enhanced the prospects of substance use disorders rehabilitation, using non-invasive brain stimulation, such as transcranial Direct Current Stimulation (tDCS). Methods: We carried out a randomized sham-controlled clinical trial to assess the effect of repeated tDCS at DLPFC on drug craving in 30 abstinent male methamphetamine users. The participants underwent 5 sessions of 20 minutes bilateral real or sham 2 mA tDCS (anode right/ cathode left) of DLPFC. The Desire for Drug Questionnaire (DDQ) was used for assessing instant craving. The cue-induced craving was rated on a Visual Analog Scale (VAS) after the verbal induction of craving. Results: The findings of this study indicated that cue-induced craving reduced significantly in tDCS related to sham (P<0.05), but tDCS did not significantly alter instant craving. Discussion: The results indicated that repeated bilateral tDCS over DLPFC was not effective in reducing self-report instant craving, but reduced self-reported craving in the craving induction condition.

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Section: Introductionmentioning

confidence: 99%