The Effects of Mold-Fermented Cheese on Brain-Derived Neurotrophic Factor in Community-Dwelling Older Japanese Women With Mild Cognitive Impairment: A Randomized, Controlled, Crossover Trial

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

“…Only one study has evaluated the effect on animal-based food consumption on cognition. In this regard, the consumption of 33.4 g/d of camembert cheese or the same amount of processed cheese made from mozzarella and cream cheese for 3 months did not produce improvements in general cognitive functions in 65 subjects with MCI [38].…”

“…These differences between centers were potentially attributed to lower levels of education and lower plasma α-linolenic acid concentrations in the Barcelona participants at baseline [37]. Animal-based foods, such as camembert cheese, worsened cognition, even when levels of the neuroprotective BDNF were high [38], but, in contrast, intake of bovine milk-derived phospholipid was shown to protect cognitive performance under stress in terms of better sustained attention. Taken together, the effects of phospholipid supplementation may be limited to subjects with high levels of stress, as they attenuate stress response mediated by the HPA axis [80].…”

Effects of nutritional interventions on BDNF concentrations in humans: a systematic review

“…In a second study, Sandberg et al [19] showed that consuming a whole grain rye kernel-based bread increased plasma BDNF concentrations in apparently healthy subjects when compared with white wheat flour-based control bread. Finally, a study in mild cognitively impaired women revealed that consuming mold-fermented cheese as compared with nonmold-fermented cheese led to a significant increase in serum BDNF concentrations [20].…”

The effect of pro-/synbiotic supplementation on the brain-derived neurotrophic factor: a systematic review and meta-analysis of randomized controlled trials

“…[20][21][22][23][24] Finally, 10 RCTs with 12 treatment arms were included in this systematic review and metaanalysis. [9][10][11][25][26][27][28][29][30][31]…”

“…All RCTs were conducted on both genders except one which was performed on women. 28 The mean age of participants ranged from 35.5 to 79.3 years old. The mean BMI of subjects ranged from 23.1 to 26.7 kg m −2 .…”