The effects of moderate sustained exercise on the pharmacokinetics of nitroglycerine.

Weber, Simon; Lauture, D. De; E, Rey; Darragon, T; Severins, J P; Ditisheim, Agnès; Olivé, G; Degeorges, M

doi:10.1111/j.1365-2125.1987.tb03018.x

Cited by 25 publications

(14 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated an increase in plasma GTN after physical exercise and exposure to a 627 sauna [3][4][5][6]. Both those conditions are associated with increased cutaneous blood flow and also with several other physiological effects.…”

Section: Discussionmentioning

confidence: 96%

“…Since 1986, however, several authors have reported that the plasma concentration of GTN may increase considerably if a patch carrier exercises [3][4][5][6], or stays in a sauna [3]. Several mechanisms could contribute to the increase during exercise; reduced nitrate metabolism, changes in the nitrate distribution volume and changes in cutaneous blood flow [6].…”

Section: Nmol 1-~mentioning

confidence: 97%

See 1 more Smart Citation

Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin

Klemsdal

Gjesdal

Bredesen

1992

Eur J Clin Pharmacol

View full text Add to dashboard Cite

19 healthy volunteers wore a nitroglycerin patch releasing 10 mg per 24 h for 2 h. Subsequently, the skin area surrounding the patch was exposed to 15 min of local heating with an infrared bulb (Group A, n = 10), or local cooling with an ice-pack (Group B, n = 9). The patch was protected by an insulating shield (Styrofoam). After 10 min of heating, the median (Walsh) plasma nitroglycerin level increased from 3.1 to 7.6 nmol.l-1. Body temperature remained constant. After 15 min of cooling the median plasma level had dropped from 2.1 to 1.4 nmol.l-1. The results demonstrate that changes in skin temperature may cause extensive short-term changes in the bioavailability of nitroglycerin. Presumably, a subcutaneous or cutaneous reservoir builds up during transdermal treatment, and changes in regional cutaneous blood flow affect the rate of drainage from the reservoir into the systemic circulation.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Nmol 1-~mentioning

confidence: 97%

Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin

Klemsdal

Gjesdal

Bredesen

1992

Eur J Clin Pharmacol

View full text Add to dashboard Cite

show abstract

“…Additionally, diffusion, which is the main mechanism of transdermal drug delivery, as a temperature-dependent process might be fastened with elevated skin and/or patch temperature [78]. Moreover, also exercising can increase cutaneous blood flow and thus result in elevated drug absorption from transdermal patches [72,77,[80][81][82][83][84][85][86]. Finally, patients can experience burns during a MRI procedure while wearing a transdermal patch with a metallic backing, which leads to induction of an electric current and the production of intense heat [87][88][89][90][91][92][93].…”

Section: Applicationmentioning

confidence: 99%

A systematic review of medication administration errors with transdermal patches

Lampert

Seiberth

Haefeli³

et al. 2014

Expert Opinion on Drug Safety

View full text Add to dashboard Cite

The systematic investigation of published errors illustrated that every step in the transdermal patch administration process is prone to errors. Thereby, the lack of knowledge and awareness of the importance of a correct administration practice were a major source of risk. Based on the identified errors and causes of errors prevention strategies were developed as a first step in avoiding transdermal patch administration errors.

show abstract

“…Measurement of the nitroglycerin concentrations in plasma can yield different results, as the concentration depends among other things on the physical stress and posture of the test person at the time of sampling (101). The rate of absorption of nitroglycerin with systems for transdermal application ("controlled delivery systems") is about 0.5 mg/cm and day (1,20).…”

Section: Cutaneous Absorptionmentioning

confidence: 99%

Nitroglycerin [BAT Value Documentation, 1998]

Bolt¹

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Published in the series Biological Exposure Values for Occupational Toxicants and Carcinogens , Vol. 3 (1998) The article contains sections titled: Pharmacokinetics and Pharmacodynamics Kinetics Metabolism Dose‐dependency of the Effects of Nitroglycerin Pharmacodynamics Interaction Critical Toxicity Exposure and Effects Relationship between External and Internal Exposure Relationship between Internal Exposure and Effect Selection of the Indicators Nitroglycerin in Blood Glycerol‐1,2‐dinitrate and Glycerol‐1,3‐dinitrate in Blood Methodology Background Exposure Evaluation of the BAT Value Interpretation of the Data

show abstract

The effects of moderate sustained exercise on the pharmacokinetics of nitroglycerine.

Cited by 25 publications

References 5 publications

Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin

Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin

A systematic review of medication administration errors with transdermal patches

Nitroglycerin [BAT Value Documentation, 1998]

Contact Info

Product

Resources

About