The Effects of Mobilization on the Vascularization of Healing Flexor Tendons in Dogs

Gelberman, Richard H.; Menon, Jayasanker; Gonsalves, Mary; Akeson, Wayne H.

doi:10.1097/00003086-198011000-00041

Cited by 128 publications

(41 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Under loading conditions, cells within the ligament sense tissue strains and respond by modifying the tissue. Mobilization for the treatment of soft tissue damage has also been found to decrease muscle atrophy, osteoporosis, adhesions, and joint stiffness following injury [125][126][127][128][129][130][131]. According to a review by Hurley and Roth, studies have indicated that, even in healthy and diseased older adults, short-term high-intensity strength training is well tolerated and helps reduce proinflammatory cytokines and knee joint loads.…”

Section: Mobilization and Exercisementioning

confidence: 99%

Ligament Injury and Healing: A Review of Current Clinical Diagnostics and Therapeutics

Hauser¹

2013

TOREHJ

View full text Add to dashboard Cite

Ligament injuries are among the most common causes of musculoskeletal joint pain and disability encountered in primary practice today. Ligament injures create disruptions in the balance between joint mobility and joint stability, causing abnormal force transmission through the joint, which results in damage to other structures in and around the joint. The long-term consequence of nonhealed ligament injury is osteoarthritis, the most common joint disorder in the world today.Ligaments heal through a distinct sequence of cellular events that take place in three consecutive stages: an acute inflammatory phase, a proliferative or regenerative phase, and a tissue remodeling phase. The process can take months to resolve itself, and despite advances in therapeutics, many ligaments do not regain their normal tensile strength.Various diagnostic procedures have been used to determine and assess ligament injury. Traditionally, MRI and X-rays have been the most utilized techniques; however, because ligaments do not show up clearly with these devices, there have been many false positives and negatives reported due to inconclusive or inaccurate readings. Newer technologies, such as ultrasound and digital motion X-ray, are able to provide a more detailed image of a ligament's structure and function.Numerous strategies have been employed over the years attempting to improve ligament healing after injury or surgery. One of the most important of these is based on the understanding that monitoring early resumption of activity can stimulate repair and restoration of function and that prolonging rest may actually delay recovery and adversely affect the tissue's response to repair. Likewise, there is a shift away from the use of steroid injections and nonsteroidal antiinflammatory medications. Although these compounds have been shown effective in decreasing the inflammation and pain of ligament injuries for up to six to eight weeks, their use has been shown to inhibit the histological, biochemical, and biomechanical properties of ligament healing. For this reason their use is cautioned against in athletes who have ligament injuries. Such products are no longer recommended for chronic soft tissue injuries or for acute ligament injuries, except for the shortest possible time, if at all.Regenerative medicine techniques, such as prolotherapy, have been shown, in both case series and clinical studies, to resolve ligament injuries of the spine and peripheral joints. More research and additional studies are needed to better assess ligament injuries and healing properties.

show abstract

Section: Mobilization and Exercisementioning

confidence: 99%

Ligament Injury and Healing: A Review of Current Clinical Diagnostics and Therapeutics

Hauser¹

2013

TOREHJ

View full text Add to dashboard Cite

show abstract

“…A variety of in vivo studies clearly have demonstrated that early mobilization following tendon repair improves the chances of a favorable outcome, including rapid development of appropriate mechanical properties at the repair site. [2][3][4][5][6][7] The dilemma is how to effectively repair a tendon so that it can be loaded passively or actively soon after surgery. While significant improvements in suturing techniques have enhanced tendon repairs, 8 biologically based bridging materials with tendon-like mechanical properties might better facilitate the postoperative repair process, particularly in gapped tendons; however, no such biomaterial currently is available.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of NDGA-polymerized collagen fibers. I. Evaluation of cytotoxicity with tendon fibroblastsin vitro

Koob¹,

Willis²,

Hernández³

2001

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

The material properties of tendon type I collagen fibers polymerized with nordihydroguaiaretic acid (NDGA) are equivalent to native tendon, suggesting that NDGA crosslinking may provide a viable approach to stabilizing collagenous materials for repairing ruptured, lacerated, or surgically transected fibrous tissues, such as tendon and ligament (Koob & Hernandez, Biomaterials, in press). Using standard cytotoxicity tests, the present study evaluated the biocompatibility of these fibers with cultured bovine tendon fibroblasts. Primary fibroblasts obtained from calf digital extensor tendons were exposed to NDGA, reaction products generated from the polymerization protocol, and the crosslinked fibers. NDGA was cytotoxic to these cells at concentrations above 100 microM. NDGA oxidation products were similarly cytotoxic. At concentrations below 100 microM, fibroblast viability was not affected by NDGA or its oxidation products. At these lower concentrations, fibroblast proliferation was unaffected compared to controls not exposed to NDGA. Fibers crosslinked with NDGA contained no unreacted NDGA, but they did contain soluble reaction products that were cytotoxic to tendon fibroblasts in both the elution and the direct contact tests. Washing the fibers in 70% ethanol and phosphate-buffered saline eliminated cytotoxicity of the fibers. Ethanol simultaneously sterilized the fibers. Tensile tests established that the ethanol/phosphate buffer wash did not adversely affect the material properties of the fibers. The results of these experiments indicate that NDGA-crosslinked fibers can be rendered nontoxic to tendon fibroblasts and may provide a novel approach for producing biologically based, biocompatible, tendon bioprostheses.

show abstract

“…Certains protocoles de rééducation fonctionnelle préconisent une mobilisation passive précoce de l'articulation talocrurale après la chirurgie [16]. Cela permettrait d'améliorer la vascularisation du tendon [17] et d'obtenir, ainsi, une récupération plus rapide de la mobilité tout en limitant le risque de raccourcissement de longueur du tendon [18]. Nous n'avons retrouvé, dans notre série, que quatre cas de diminution significative de la flexion dorsale de la cheville.…”

Section: Discussionunclassified

Suture percutanée des ruptures fraîches du tendon calcanéen

Rouvillain¹,

Navarre²,

Labrada-Blanco³

et al. 2008

Journal de Traumatologie du Sport

View full text Add to dashboard Cite

The Effects of Mobilization on the Vascularization of Healing Flexor Tendons in Dogs

Cited by 128 publications

References 0 publications

Ligament Injury and Healing: A Review of Current Clinical Diagnostics and Therapeutics

Ligament Injury and Healing: A Review of Current Clinical Diagnostics and Therapeutics

Biocompatibility of NDGA-polymerized collagen fibers. I. Evaluation of cytotoxicity with tendon fibroblastsin vitro

Suture percutanée des ruptures fraîches du tendon calcanéen

Contact Info

Product

Resources

About