The Effects of MiR-214-3p and Irisin/FNDC5 on the Biological Behavior of Osteosarcoma Cells

Chen, Gong; Xu, Duanfu; Chu, Kai; Cao, Zhilin; Sun, Xiujiang; Yang, Yong

doi:10.1089/cbr.2019.2933

Cited by 12 publications

(19 citation statements)

References 29 publications

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“…In previous studies, miR-214 was upregulated in osteosarcoma cells and was associated with tumor progression and poor prognosis [82]. Cheng et al [81] found that miR-214-3p inhibited FNDC5/Ir expression, thus contributing to the activation of migration, invasion, and EMT of osteosarcoma cells. Previous studies showed that Ir activated osteocytes through the αV/β5 integrin receptor [36].…”

Section: Osteosarcomamentioning

confidence: 94%

“…Cheng et al [81] showed a decreased level of FNDC5/Ir in serum and tissues of osteosarcoma patients. The researchers also performed in vitro studies using osteosarcoma U2OS cell lines and found that Ir inhibited U2OS cell viability in a concentration-and time-dependent manner and could inhibit tumor cell migration and invasion.…”

Section: Osteosarcomamentioning

confidence: 99%

“…Osteoclast activity leads to bone degradation and the release of protumor factors, such as insulin-like growth factor 1 (IGF1) or transforming growth factor-β (TGF-β), which enhance osteosarcoma cell proliferation [83]. Cheng et al [81] indicated a protective role of Ir in the proliferation and metastasis of osteosarcoma. These authors indicated that Ir could be used for osteosarcoma therapy in the future.…”

Section: Osteosarcomamentioning

confidence: 99%

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The Role of Irisin in Cancer Disease

Pinkowska

Podhorska‐Okołów

Dzięgiel

et al. 2021

Cells

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Irisin (Ir) is an adipomyokine that is involved in the regulation of metabolic processes. It also influences processes related to inflammation, including cancer. Initially, Ir was considered a hormone secreted by skeletal muscles in response to physical exercise. Further studies showed that Ir is also present in other healthy tissues, organs, and plasma. It influences the change in phenotype of white adipose tissue (WAT) into brown adipose tissue (BAT). It increases mitochondrial biogenesis and affects the expression of thermogenin (UCP1). This adipomyokine has also been found in many tumor tissues and in the serum of cancer patients. Studies are underway to determine the association between Ir and carcinogenesis. It has been confirmed that Ir inhibits in vitro proliferation, migration, and invasion. It is involved in the inhibition of epithelial–mesenchymal transition (EMT). Additionally, Ir affects the expression of the transcription factor Snail, which is involved in EMT, and inhibits transcription of the gene encoding E-cadherin, which is characteristic of epithelial-derived cells. Many studies have been performed to determine the role of Ir in physiological and pathological processes. Further detailed studies should determine more precisely the effect of Ir on the body in health and disease.

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Section: Osteosarcomamentioning

confidence: 94%

Section: Osteosarcomamentioning

confidence: 99%

Section: Osteosarcomamentioning

confidence: 99%

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The Role of Irisin in Cancer Disease

Pinkowska

Podhorska‐Okołów

Dzięgiel

et al. 2021

Cells

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“…Cheng et al investigated the effects of irisin on human osteosarcoma U2OS cells [ 83 ]. Irisin dose-dependently inhibited the viability, migration and invasion of osteosarcoma cells.…”

Section: Role Of Irisin In Cancermentioning

confidence: 99%

“…Irisin dose-dependently inhibited the viability, migration and invasion of osteosarcoma cells. MicroRNA miR-214-3p inhibited irisin/FNDC5 expression and promoted migration, epithelial/mesenchymal transition (EMT) and the invasion of U2OS cells [ 83 ] ( Table 1 ). This study suggests a potential of targeting irisin and miR-214-3p towards the treatment of osteosarcoma.…”

Section: Role Of Irisin In Cancermentioning

confidence: 99%

Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani

Tsakiridis

Kouvelioti

et al. 2021

Cancers

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Cancer is a disease associated with extreme human suffering, a huge economic cost to health systems, and is the second leading cause of death worldwide. Regular physical activity is associated with many health benefits, including reduced cancer risk. In the past two decades, exercising/contracting skeletal muscles have been found to secrete a wide range of biologically active proteins, named myokines. Myokines are delivered, via the circulation, to different cells/tissues, bind to their specific receptors and initiate signaling cascades mediating the health benefits of exercise. The present review summarizes the existing evidence of the role of the myokine irisin in cancer. In vitro studies have shown that the treatment of various cancer cells with irisin resulted in the inhibition of cell proliferation, survival, migration/ invasion and induced apoptosis by affecting key proliferative and antiapoptotic signaling pathways. However, the effects of irisin in humans remains unclear. Although the majority of the existing studies have found reduced serum irisin levels in cancer patients, a few studies have shown the opposite. Similarly, the majority of studies have found increased levels of irisin in cancer tissues, with a few studies showing the opposite trend. Clearly, further investigations are required to determine the exact role of irisin in cancer.

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FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway

Li,

Wang,

et al. 2024

Journal Cellular Physiology

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Cervical cancer (CxCa) is the fourth most frequent cancer in women. This study aimed to determine the role and underlying mechanism of fibronectin type III domain‐containing protein 5 (FNDC5) in inhibiting CxCa growth. Experiments were performed in human CxCa tissues, human CxCa cell lines (HeLa and SiHa), and xenograft mouse model established by subcutaneous injection of SiHa cells in nude mice. Bioinformatics analysis showed that CxCa patients with high FNDC5 levels have a longer overall survival period. FNDC5 expression was increased in human CxCa tissues, HeLa and SiHa cells. FNDC5 overexpression or FNDC5 protein not only inhibited proliferation, but also restrained invasion and migration of HeLa and SiHa cells. The effects of FNDC5 were prevented by inhibiting integrin with cilengitide, activating PI3K with recilisib or activating Akt with SC79. FNDC5 inhibited the phosphorylation of PI3K and Akt, which was attenuated by recilisib. PI3K inhibitor LY294002 showed similar effects to FNDC5 in HeLa and SiHa cells. Intravenous injection of FNDC5 (20 μg/day) for 14 days inhibited the tumor growth, and reduced the proliferation marker Ki67 expression and the Akt phosphorylation in the CxCa xenograft mouse model. These results indicate that FNDC5 inhibits the malignant phenotype of CxCa cells through restraining PI3K/Akt signaling. Upregulation of FNDC5 may play a beneficial role in retarding the tumor growth of CxCa.

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The Effects of MiR-214-3p and Irisin/FNDC5 on the Biological Behavior of Osteosarcoma Cells

Cited by 12 publications

References 29 publications

The Role of Irisin in Cancer Disease

The Role of Irisin in Cancer Disease

Current Evidence of the Role of the Myokine Irisin in Cancer

FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway

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