The effects of midazolam and flumazenil on psychomotor function

Gupta, Anil; Lind, Susanne; Eklund, Arne; Lennmarken, C.

doi:10.1016/s0952-8180(96)00214-0

Cited by 11 publications

(6 citation statements)

References 12 publications

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“…The impaired anxiolytic action of BZD was also previously observed in rats treated with k-opioid receptor antagonists (Tsuda et al, 1996) and in other animal models showing increased anxiety (Bailey and Toth, 2004;Commissaris et al, 1990;Sibille et al, 2000;Urigu¨en et al, 2004). Furthermore, several reports have shown a variable sensitivity in the response to BZD treatment in the human population (Domino et al, 1989;Gupta et al, 1997), particularly in those groups of patients with anxiety disorders presenting diminished response to benzodiazepine treatment (Cowley et al, 1997;Kaschka et al, 1995;Nutt and Glue, 1989;Schlegel et al, 1994). These findings suggest that alterations in GABA A receptor functional activity may be underlying the impaired anxiolytic response to benzodiazepines (Bailey and Toth, 2004;Bremner et al, 2000;Crestani et al, 1999;Kaschka et al, 1995;Malizia et al, 1998;Rainnie et al, 1992;Schlegel et al, 1994;Tiihonen et al, 1997).…”

Section: Discussionmentioning

confidence: 59%

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Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABA_A receptor subunits gene expression in the amygdala

et al. 2010

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This study evaluated the role of prodynorphin gene in the regulation of anxiety and associated molecular mechanisms. Emotional responses were assessed using the light-dark test, elevated plus maze and social interaction tests in prodynorphin knockout and wild-type mice. Corticotrophin releasing factor and proopiomelanocortin gene expressions in the hypothalamus were evaluated after restraint stress using in situ hybridization. The anxiolytic efficacy of bromazepam and GABA(A) receptor subunits gene expression in the amygdala were also assessed in both genotypes. The deletion of prodynorphin increased anxiety-like behaviours and proopiomelanocortin gene expression in the arcuate nucleus (two-fold). Moreover, the anxiolytic action of bromazepam was significantly attenuated in the mutant mice. Decreased GABA(A)γ(2) and increased GABA(A)β(2) gene expression receptor subunits were found in the amygdala of prodynorphin knockout mice. These results indicate that deletion of prodynorphin gene is associated with increased anxiety-like behaviours, enhanced sensibility response to stress stimuli, reduced anxiolytic efficacy of bromazepam and altered expression of the GABA(A) receptor subunits.

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Section: Discussionmentioning

confidence: 59%

“…Furthermore, several reports have shown a variable sensitivity in the response to BZD treatment in the human population (Domino et al . , 1989; Gupta et al . , 1997), particularly in those groups of patients with anxiety disorders presenting diminished response to benzodiazepine treatment (Cowley et al .…”

Section: Discussionmentioning

confidence: 99%

Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABA_A receptor subunits gene expression in the amygdala

et al. 2010

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“…Other workers have reported such a variation in response to both midazolam and flumazenil. 17 Sedated subjects given flumazenil had significantly improved psychomotor function when compared to those subjects who received saline. Mean light reaction times returned to baseline at 10 Alertness was significantly different between the subjects receiving midazolam followed by saline and the control group (saline followed by saline).…”

Section: Discussionmentioning

confidence: 93%

The effects of midazolam and flumazenil on psychomotor function and alertness in human volunteers

Coulthard¹,

Sano²,

Thomson³

et al. 2000

Br Dent J

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“…Each answer is scored from 1 to 5. A total of 20 points can be obtained, with a score above 15 suggesting the presence of a dental phobia [23]. The Corah scale is another Dental Anxiety Scale which can be used in children [24].…”

Section: Effect Of Passiflora Treatments On Neuropsychiatric Parametersmentioning

confidence: 99%

Passiflora incarnata in Neuropsychiatric Disorders—A Systematic Review

et al. 2020

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Background: Stress is a natural response of the body, induced by factors of a physical (hunger, thirst, and infection) and/or psychological (perceived threat, anxiety, or concern) nature. Chronic, long-term stress may cause problems with sleep, concentration, and memory, as well as affective disorders. The passionflower (Passiflora incarnata) is a perennial plant with documented therapeutic properties. The literature data suggest that the passionflower itself, as well as its preparations, helps reduce stress and can therefore be helpful in the treatment of insomnia, anxiety, and depression. The objective of this systematic review was to evaluate Passiflora incarnata in terms of its neuropsychiatric effects. Methods: The scientific databases PubMed, ClinTrials.gov, and Embase were searched up to 22 October 2019. The search identified randomized clinical trials describing the effects of Passiflora incarnata in neuropsychiatric disorders. Results: The systematic review included nine clinical trials. The duration of the studies included in the analysis varied widely, from one day up to 30 days. Study participants were no less than 18 years old. In each of the papers, the effects of passionflower were measured by using a number of different tests and scales. The majority of studies reported reduced anxiety levels following the administration of Passiflora incarnata preparations, with the effect less evident in people with mild anxiety symptoms. No adverse effects, including memory loss or collapse of psychometric functions, were observed. Conclusion: Passiflora incarnata may be helpful in treating some symptoms in neuropsychiatric patients.

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The effects of midazolam and flumazenil on psychomotor function

Cited by 11 publications

References 12 publications

Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABA_A receptor subunits gene expression in the amygdala

Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABA_A receptor subunits gene expression in the amygdala

The effects of midazolam and flumazenil on psychomotor function and alertness in human volunteers

Passiflora incarnata in Neuropsychiatric Disorders—A Systematic Review

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The effects of midazolam and flumazenil on psychomotor function

Cited by 11 publications

References 12 publications

Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABAA receptor subunits gene expression in the amygdala

Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABAA receptor subunits gene expression in the amygdala

The effects of midazolam and flumazenil on psychomotor function and alertness in human volunteers

Passiflora incarnata in Neuropsychiatric Disorders—A Systematic Review

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Product

Resources

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Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABA_A receptor subunits gene expression in the amygdala

Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABA_A receptor subunits gene expression in the amygdala