The effects of methyl tert-butyl ether (MTBE) on the male rat reproductive system

Li, Dongmei; Yuan, Chuntao; Gong, Yi; Huang, Yu‐Feng; Han, Xiaodong

doi:10.1016/j.fct.2008.03.024

Cited by 25 publications

(15 citation statements)

References 22 publications

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“…A subsequent in vivo reproductive toxicity publication by Li et al (16) appeared after all of our experiments were completed showed serum testosterone to be lower in male rats gavaged with high doses of MTBE for 14 or 28 days. Seeing this effect in rats was not surprising to us, since we and others had reported similar testosterone-lowering effects in Sprague-Dawley rats given high bolus doses (5,6).…”

Section: Discussionmentioning

confidence: 83%

“…Reactive oxygen species, membrane lipid peroxidation, and extracellular superoxide dismutase increased, while cytosolic superoxide dismutase decreased. Like the experiments just mentioned, a second paper also appearing in the literature after we had completed our experiments describes other evidence of oxidative stress in male Sprague-Dawley rats (16). In those studies high gavage doses of MTBE ranging from 400 mg/kg to 1600 mg/kg were administered daily for 14 or 28 days.…”

Section: Introductionmentioning

confidence: 87%

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Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver

Peyster¹,

Rodriguez²,

Shuto³

et al. 2008

Reproductive Toxicology

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MTBE is found in water supplies used for drinking and other purposes. These experiments follow up on earlier reports of reproductive tract alterations in male mice exposed orally to MTBE and explored oxidative stress as a mode of action. CD-1 mice were gavaged with 400–2000 mg/kg MTBE on days 1, 3, and 5, injected ip with hCG (2.5 IU/g) on day 6, and necropsied on day 7. No effect was seen in testis histology or testosterone levels. Using a similar dosing protocol, others had initially reported disruption of seminiferous tubules in MTBE–gavaged mice, although later conclusions published were consistent with our findings. Another group had also reported testicular and other reproductive system abnormalities in male BALB/c mice exposed for 28 days to 80–8000 ug/ml MTBE in drinking water. We gave these MTBE concentrations to adult mice for 28 days and juvenile mice for 51 days through PND 77. Evidence of oxidative stress was examined in liver homogenates from the juvenile study using MDA, TEAC and 8OH2hG as endpoints. MTBE exposures at the levels examined indicated no significant changes in the male mouse reproductive tract and no signs of hepatic oxidative stress. This appears to be the first oral MTBE exposure of juvenile animals, and also the first to examine potential for MTBE to cause oxidative stress in vivo using a typical route of human exposure.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 87%

Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver

Peyster¹,

Rodriguez²,

Shuto³

et al. 2008

Reproductive Toxicology

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show abstract

“…Furthermore, the studies on male reproductive hormones had inconsistent results. For example increase, decrease and no changes in testosterone levels have been reported in previous studies (Day et al, 1998[ 11 ]; Williams et al, 2000[ 22 ]; Billiti et al, 2005[ 7 ]; Li et al, 2008[ 16 ]; Bermudez et al, 2012[ 4 ]). On the other hand, one interesting aspect of reproduction is the sex ratio of offspring at birth.…”

Section: Introductionmentioning

confidence: 77%

“…Furthermore, there are very limited data about the role of oxidative stress in reproductive effect of MTBE (Li et al, 2007[ 15 ], 2008[ 16 ], 2009[ 14 ]). It has been shown that MTBE increased the production of reactive oxygen species (ROS) and enhanced lipid peroxidation in isolated rat spermatogenic cells (Li et al, 2007[ 15 ]), can exert reproductive system toxicity of male rats and disturb the secretions of sex hormones possibly due to induction of oxidative stress (Li et al, 2008[ 16 ]) and also has a direct toxic effect on cultured rat Sertoli cells (Li et al, 2009[ 14 ]).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of offspring sex ratio, sex hormones and antioxidant enzymes following exposure to methyl tertiary butyl ether in adult male Sprague-dawley rats

Khalili

Gholami

Ansari-Lari

2015

EXCLI Journal; 14:Doc75; ISSN 1611-2156

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“…Adverse effects included a significant increase in abnormal sperm, histopathological changes in seminiferous epithelium, alterations in serum testosterone, luteinizing hormone and follicle stimulating hormone, and decreases in androgen binding protein (Li et al, 2008). Adverse effects included a significant increase in abnormal sperm, histopathological changes in seminiferous epithelium, alterations in serum testosterone, luteinizing hormone and follicle stimulating hormone, and decreases in androgen binding protein (Li et al, 2008).…”

Section: Developmental and Reproductive Toxicitymentioning

confidence: 99%

Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III

2012

EFSA Journal

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Shipping of edible fats and oils into Europe is permitted in bulk tanks, in which substances, included in a positive list, had been previously transported. The European Commission requested EFSA to evaluate the list of substances in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils, taking into account its review of the Scientific Committee on Food (SCF) criteria for acceptable previous cargoes and criteria proposed by the Codex Committee for Fats and Oils. This is the second of three scientific opinions by the Panel on Contaminants in the Food Chain (CONTAM Panel), in which thirty-five of these substances or groups of substances have been evaluated. The CONTAM Panel concluded that fatty acids, fatty alcohols, fatty alcohol blends, fatty acid methyl esters, fatty acid esters, and animal, marine and vegetable and hydrogenated oils and fats, all as specified, and acid oils and fatty acid distillates, acetic acid, sulphuric acid, formic acid, acetic anhydride, acetone, n-heptane, n-hexane, cyclohexane, pentane, iso-propanol, propyl alcohol, methyl isobutyl ketone, methyl ethyl ketone, n-propyl acetate, ammonium hydroxide, limonene, methyl tertbutyl ether, urea ammonia nitrate solution, calcium chloride solution, magnesium chloride solution, potable water, potassium hydroxide, sodium hydroxide, silicon dioxide, sorbitol, molasses and beeswax would not be of health concern as previous cargoes. However, because of its insolubility in water and high melting point, silicon dioxide is not suitable for transport in tankers for edible fats and oils. There was insufficient information available on the composition of wine lees for the CONTAM Panel to conclude that it would not be of health concern when used as a previous cargo. The CONTAM Panel made several recommendations regarding the way in which the substances are described in the Annex to Commission Directive 96/3/EC, to correct inaccuracies and to better reflect current transport practices. for the preparatory work on this scientific opinion and the hearing expert John Hancock, and EFSA staff: Gina Cioacata and Luisa Ramos Bordajandi for the support provided to this scientific opinion. 4 Corrections have been made to Section 3.3.3 and to Section Conclusions (page 107, second bullet) for the entry on -Fatty alcohols (individually specified)‖ to list enanthyl alcohol (1-heptanol) and nonyl alcohol (1-nonanol) that due to an omission were not listed. The changes do not affect the overall conclusions of the opinion. To avoid confusion, the original version of the opinion has been removed from the website, but is available on request, as is a version showing all the changes made. Re-evaluation of acceptable previous cargoes for edible fats and oils -Part II of III EFSA Journal 2012;10(5):2703 2 © European Food Safety Authority, 2012 KEY WORDS Acceptable previous cargo, edible fats and oils, sea transport, criteria for acceptability of previous cargoes Re-evaluation of acceptable previous cargoes for edible fats and oils -Part I...

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The effects of methyl tert-butyl ether (MTBE) on the male rat reproductive system

Cited by 25 publications

References 22 publications

Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver

Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver

Evaluation of offspring sex ratio, sex hormones and antioxidant enzymes following exposure to methyl tertiary butyl ether in adult male Sprague-dawley rats

Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III

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