The effects of mechanical vibration on bone development in the rat

Effects of mechanical vibration on DNA and proteoglycan syntheses in cultured articular chondrocytes

“…Several research reports have shown that a mechanical vibratory load is conducted to fracture or implant sites where micromovement occurs between both fragments, and this may have a beneficial influence on bone regeneration and its healing process. 15,17,[25][26][27][28] This alternating motion due to mechanical vibration also promotes cartilage formation between bone fragments. 26 Some investigators have reported that different types of mechanical environments at cartilage explants, such as dynamic mechanical compression and/or stretch loads, can modulate chondrocyte metabolism.…”

“…These studies have shown that loading enhances the tendon fibroblasts of embryonic chicks, promotes the healing of fractures in rabbits and rats, increases the concentration of insulin-like growth factor I (IGF-I) in the tendons and peripheral nerves of rats, and relieves neurogenic or musculoskeletal pain in humans. 1,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] While the mechanisms of action for these various effects remain unclear, they likely differ with different modes of vibration. 15,17,20 In this study, the effects of vibratory load on articular chondrocytes in vitro were assessed by changes in DNA and proteoglycan syntheses as measured by 3 4 (1 mCi/ml) and 3 H-thymidine (2 mCi/ ml) were obtained from NEN Life Science Products (Daiichi Pure Chemical Co., Tokyo, Japan).…”

Effects of vibration treatment on tibial bone of ovariectomized rats analyzed by in vivo micro‐CT

“…Finally, it should be noted that although the effects of WBV on femoral, epiphyseal bone microstructure in the study by Judex et al 1 were considerable, in general the effects of WBV on bone microstructure and BMD have shown to vary per site, species, and study design. [1][2][3]5,[8][9][10]13,14,16,36 As no significant effects of WBV therapy on bone structural parameters were determined, it is important to ascertain that the mechanical stimulus was indeed transported from the vibration platform to the rat tibia. The mechanical stimulus used in this study was vertically directed via a ground-based vibration platform.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] These mechanical signals are often applied in high-frequency, low-acceleration mode, and commonly result in small strains (<10 microstrain) in the bone, that are orders of magnitude lower than strains resulting from daily loads. 1,7 As they are apparently harmless to the body, they may provide a potential treatment for bone-debilitating diseases like osteoporosis.…”

“…Keywords: vibration; rats; ovariectomy; in vivo micro-CT Mechanical stimulation of bone by vibration has been shown in vivo to have a potential osteogenic effect, contributing to a structure more resistant to habitual loads. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] These mechanical signals are often applied in high-frequency, low-acceleration mode, and commonly result in small strains (<10 microstrain) in the bone, that are orders of magnitude lower than strains resulting from daily loads.1,7 As they are apparently harmless to the body, they may provide a potential treatment for bone-debilitating diseases like osteoporosis.In a study performed in sheep, 1 year of daily vibrations resulted in an increase of trabecular bone volume fraction of 32%. 8 In a study in which teenagers with low bone mineral density (BMD) were put on a vibration plate for 10 min a day for a year, a small increase in trabecular BMD in lumbar vertebrae was found as well as an increase in femoral cortical bone area.…”