The effects of mebudipine on myocardial arrhythmia induced by ischemia-reperfusion injury in isolated rat heart

Ghiasi, Rafighe; Mohammadi, Mustafa; Majidinia, Maryam; Yousefi, Bahman; Ghiasi, Ahmad; Badalzadeh, Reza

doi:10.14715/cmb/2016.62.13.4

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…However, limited studies have reported the protective role of T1AM in vivo. Myocardial ischemia reperfusion can lead to lethal ventricular arrhythmias (18). The current data showed that T1AM decreased the incidence of VF, suggesting that T1AM can attenuate MIRI.…”

Section: Discussionsupporting

confidence: 48%

3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway

Zhou¹,

Mo²,

Huang³

et al. 2022

Ann Transl Med

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Background: This study investigated the potential effects of 3-iodothyronamine (T1AM) on myocardial ischemia reperfusion injury (MIRI) and the underlying molecular mechanisms.Methods: A total of 16 adult male Sprague-Dawley rats were randomly divided into 4 groups and administered the following: control (60% DMSO and 40% saline, pH 7.4), T1AM (25 mg/kg), T1AM (50 mg/kg), or T1AM (100 mg/kg). The rectal temperatures of the rats were measured at different time points. A further 30 adult male Sprague-Dawley rats were randomized and divided into the following 3 groups (n=10 in each group): sham operation, ischemia/reperfusion (I/R), and I/R + T1AM. In the I/R and I/R + T1AM groups, the left anterior descending (LAD) coronary artery of the rats were occluded for 0.5 hour to induce myocardial ischemia, followed by reperfusion for 3 hours in the I/R group. The electrocardiography (ECG), cardiac function, and 2,3,5-triphenyltetrazolium chloride (TTC) staining were examined in rats to evaluate the myocardial injury. The differences in the expression of apoptosis-related and Akt-FoxO1 signaling-related proteins were determined via Western blot.Results: This work verified that T1AM reduced the body temperature of rats in a dose-dependent manner.Additionally, T1AM improved cardiac function and decreased the infarction size caused by MIRI. T1AM reduced the expression of biochemical parameters and apoptosis of myocardial cells. In addition, after treatment with T1AM, the expression of Glut1, pFoxO1 and Akt were reduced, while the expression of FoxO1 and PPARα were increased significantly.Conclusions: Pretreatment of cardiomyocytes with T1AM inhibited apoptosis and protected against ischemia reperfusion injury via the Akt/FoxO1 signaling pathway.

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Section: Discussionsupporting

confidence: 48%

3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway

Zhou¹,

Mo²,

Huang³

et al. 2022

Ann Transl Med

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“…Myocardial ischemia-reperfusion (I/R) injury is the lesion in which the blood perfusion is restored after the myocardial blood supply is interrupted for a certain period, leading to the injury or dysfunction in ischemic area 1 . Myocardial I/R injury can lead to the impairment of cardiac function and damage of myocardial cells, which increases the risk of cardiovascular events, such as myocardial infarction and arrhythmia, and seriously affects the prognosis of underlying diseases 2 , 3 . In addition, the myocardial I/R injury can limit the application of coronary thrombolysis treatment, interventional therapy and bypass surgery 4 .…”

Section: Introductionmentioning

confidence: 99%

Astragaloside IV alleviates myocardial ischemia-reperfusion injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways

Wei

Gai

et al. 2019

Acta Cir. Bras.

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Purpose:To investigate the effect of astragaloside IV (As-IV) on myocardial ischemia-reperfusion (I/R) injury in rats and reltaed mechanisms.Methods:Sixty rats were randomly divided into sham-operated, control I/R and 2.5, 5 and 10 mg/kg As-IV groups, 12 rats in each group. The later three groups were intragastrically administered with As-IV for 7 days, with a dose of 2.5, 5 and 10 mg/kg, respectively. The myocardial I/R injury model was constructed in later four groups. At the end of reperfusion, the cardiac function indexes, serum lactate dehydrogenase (LDH) and creatine kinase (CK) levels, heart weight (HW)/body weight (BW) ratio and infarct size, and expressions of phosphatidylinositol-3 kinase/serine-threonine protein kinase (PI3K/AKT) and glycogen synthase kinase-3β (GSK-3β) proteins and the phosphorylated forms (p-AKT, p-GSK-3β) were determined.Results:Compared with control I/R group, in 5 and 10 mg/kg As-IV groups the left ventricular systolic pressure, fractional shortening and ejection fraction were increased, the left ventricular end-diastolic pressure was decreased, the serum LDH and CK levels were decreased, the HW/BW ratio and myocardial infarct size were decreased, and the p-Akt/Akt ratio and p-GSK-3β/GSK-3β ratio were increased (all P < 0.05).Conclusion:As-IV can alleviate the myocardial I/R injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways.

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“…The study closely monitored electrocardiographs, assessed serum lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities in coronary effluent, and examined the microscopic architecture of the myocardium. Mebudipine demonstrated a reduction in ventricular arrhythmias, an improvement in edema and inflammation, and decreased tissue damage compared to the control group (15).…”

Section: Effects On Heart Myocardial Arrhythmia Induced By Ischemia-r...mentioning

confidence: 81%

“…Following an ischemic injury, reestablishing blood flow to the heart can lead to hazardous cardiac arrhythmias and the death of myocardial cells through apoptosis and necrosis. Calcium channel blockers (CCBs) have been recognized for their ability to safeguard the myocardium from damage and arrhythmias (15). Ghiasi et al conducted a study to investigate mebudipine's impact on myocardial arrhythmias and tissue injury in isolated rat hearts subjected to ischemia/reperfusion.…”

Section: Effects On Heart Myocardial Arrhythmia Induced By Ischemia-r...mentioning

confidence: 99%

Mebudipine as an Overlooked Cardioprotective Drug: A Review Study

Rahimi Petrudi,

Seyfi,

Hassanshahi

2023

Ann Mil Health Sci Res

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Context: Calcium channel blockers (CCBs) play a crucial role in the treatment of cardiovascular diseases. Mebudipine, a dihydropyridine derivative CCB, was first synthesized in 1997. This study explores the potential benefits of mebudipine in managing cardiovascular disease, particularly as a derivative of nifedipine. Evidence Acquisition: The article succinctly presents the advancements in mebudipine research, which were uncovered through extensive searches in reputable scientific databases such as ScienceDirect, Google Scholar, Scopus, and PubMed, conducted by 2 blinded researchers. The search focused on studies relevant to mebudipine, using specific keywords. Results: Mebudipine exhibits cardioprotective effects, reducing the occurrence of arrhythmias and minimizing heart tissue damage. Additionally, it has been found to enhance the levels of nitric oxide metabolites. Due to its limited solubility in water, mebudipine is typically administered using a nanoemulsion. Importantly, it has been deemed a safe drug without mutagenic effects. Conclusions: Our review study underscores that mebudipine not only has a cardioprotective effect but also offers protection to other organs against various forms of injury induction. The mechanisms responsible for these protective effects may be linked to its ability to counteract oxidative stress, prevent apoptosis, and mitigate inflammation. Nevertheless, further research is needed to fully elucidate its potential.

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The effects of mebudipine on myocardial arrhythmia induced by ischemia-reperfusion injury in isolated rat heart

Cited by 9 publications

References 24 publications

3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway

3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway

Astragaloside IV alleviates myocardial ischemia-reperfusion injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways

Mebudipine as an Overlooked Cardioprotective Drug: A Review Study

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