The Effects of Maternally Administered Pethidine or Epidural Bupivacaine on the Fetus and Newborn

Lieberman, Brian A.; Rosenblatt, D. B.; Belsey, E M; Packer, Michael G.; Redshaw, Margaret; Mills, M.S.; Caldwell, John; Notarianni, L. J.; Smith, Robert L.; Williams, Mandy; Beard, R. W.

doi:10.1111/j.1471-0528.1979.tb10820.x

Cited by 58 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found no significant difTerences at all in these groups and, if anything, the auditory and visual orientation in the group on pethidine alone were marginally better but this difference did not reach statistical significance. These observations parallel those of Tronick et al (1976) and Lieberman et al (1979).…”

Section: Discussionsupporting

confidence: 84%

Neurological and Neurobehavioural Differences Between Preterm Infants at Term and Full-Term Newborn Infants

et al. 1982

View full text Add to dashboard Cite

A detailed neurological and neurobehavioural examination was done in 80 preterm infants of 27 to 35 weeks gestation in the first week of life and again at 40 weeks postmenstrual age, and in 40 appropriately-sized full-term infants on the first and fifth days of life. There were several consistent differences between the preterm infants reaching term and the newborn full-term infants. The preterm infants reaching 40 weeks showed less flexion in their posture, and less arm traction, arm recoil and leg recoil than the full-term infants on day 1, although this difference was less apparent by day 5. The preterm infants appeared not to develop the flexor tone of the full-term newborn. The preterm infants demonstrated better visual and auditory orientation and alertness than the full-term infants. The significance of these findings, both for initial neonatal examinations and for subsequent assessments, is evaluated.

show abstract

Section: Discussionsupporting

confidence: 84%

Neurological and Neurobehavioural Differences Between Preterm Infants at Term and Full-Term Newborn Infants

et al. 1982

View full text Add to dashboard Cite

show abstract

“…It is clear that the newborn may be at least transiently affected by anesthetics and analgesics administered during labor and delivery. 3,[33][34][35] For example, the use of opioids for labor analgesia is associated with neonatal respiratory depression. In contrast to these short-term effects, there are only few studies attempting to assess the effect of mode of delivery on long-term child neurodevelopment.…”

Section: Discussionmentioning

confidence: 99%

Anesthesia for Cesarean Delivery and Learning Disabilities in a Population-based Birth Cohort

Šprung¹,

Flick²,

Wilder³

et al. 2010

Obstetric Anesthesia Digest

View full text Add to dashboard Cite

T he impact of obstetric anesthesia on short and long-term behavior and development of a neonate/child is not thoroughly understood. In animal studies, exposure of fetuses/neonates to anesthetics administered to the mother causes histopathologic changes in the brain; even single, relatively brief administrations may be associated with a diminished capacity to retain learned behavior and/or abnormal behaviors resembling autism. The significance of this in humans is not clear, but the authors of this study recently showed that repeated (not single) exposures to anesthesia before the age of 4 years may double the risk of learning disabilities (LD) in a child. Using data from the same population-based birth cohort, they examined the possible association between fetal exposure to anesthesia during cesarean delivery (CS) and the subsequent development of LD in the child.Records of all children born in Rochester, Minnesota, between January 1, 1976 and December 31, 1982 to women living in one county school district (n = 8548) were reviewed. Those still living in the district at 5 years of age (n = 5718) were identified for the cohort. School, medical, and Reading Center/ Dyslexia Institute records were used to identify those with a potential LD [n = 1510 (26%)]. Finally, children meeting criteria based on standard measures of intelligent quotient and/or achievement within the same calendar year and before the age of 19 years having at least 1 of 3 LD (reading, written language, and math disorders) were considered cases.From the total possible subjects, exclusion of 19 children with severe mental retardation and 379 with authorization issues left the cohort with 5320 children; 4823 (90.7%) delivered vaginally, 193 (3.6%) by CS with general anesthesia (most including sodium thiopental, nitrous oxide, and potent inhalational anesthetics), and 304 (5.7%) by CS with regional anesthesia. Mean exposures to anesthetics were: epidural, 63.5 minutes; spinal, 21 minutes; and general, 14 minutes. Among 921 (17.3%) actual LD cases, incidence for children whose mothers delivered vaginally was 20.8% versus 19.4% for children delivered through CS with general anesthesia and 15.4% for children born through CS with regional anesthesia. With unadjusted proportional hazard regression, the incidence of LD was not increased in children born through CS compared with those born through vaginal delivery (overall, P = 0.135). However, after adjusting for risk factors for LD, the data suggested the risk of LD may be decreased in children delivered through CS under regional anesthesia compared with those delivered vaginally. The authors concluded that these results suggest that brief perinatal exposure to anesthetic drugs does not adversely affect long-term neurodevelopment. As children born by CS under regional anesthesia had a lower incidence of LD than the other 2 groups, they hypothesize that regional anesthesia for CS may attenuate the neonatal stress response to delivery sufficiently to have significant effects on later neural development. Li...

show abstract

“…Keeping the above caveats in mind, the studies that were done using bupivacaine, which is the most common anesthetic used for labor epidurals at this time, have reported conflicting results with regard to neurobehavioral changes (82‐89). One study found neonates born to mothers with an epidural habituated and oriented better to inanimate auditory stimuli at 1 day of age (90).…”

Section: Fetal and Neonatal Effects Of Epidural Anesthesiamentioning

confidence: 99%

Epidural anesthesia in labor benefits versus risks

King¹

1997

Journal of Nurse-Midwifery

View full text Add to dashboard Cite

The Effects of Maternally Administered Pethidine or Epidural Bupivacaine on the Fetus and Newborn

Cited by 58 publications

References 14 publications

Neurological and Neurobehavioural Differences Between Preterm Infants at Term and Full-Term Newborn Infants

Neurological and Neurobehavioural Differences Between Preterm Infants at Term and Full-Term Newborn Infants

Anesthesia for Cesarean Delivery and Learning Disabilities in a Population-based Birth Cohort

Epidural anesthesia in labor benefits versus risks

Contact Info

Product

Resources

About