2020
DOI: 10.1016/j.neuint.2020.104688
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The effects of manganese overexposure on brain health

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Cited by 84 publications
(36 citation statements)
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“…However, the case for dietary Mn deficiency appears to be extremely rare in humans due to high levels of Mn in dietary products [7,8]. In contrast, Mn overexposure, which is far more common, may cause brain-associated disorders [9]. Studies on neurological outcomes have been carried out in populations living in areas near industrial activities, including former and active Mn alloys plants, and Mn ore processing plants [10][11][12][13], among others.…”
Section: Introductionmentioning
confidence: 99%
“…However, the case for dietary Mn deficiency appears to be extremely rare in humans due to high levels of Mn in dietary products [7,8]. In contrast, Mn overexposure, which is far more common, may cause brain-associated disorders [9]. Studies on neurological outcomes have been carried out in populations living in areas near industrial activities, including former and active Mn alloys plants, and Mn ore processing plants [10][11][12][13], among others.…”
Section: Introductionmentioning
confidence: 99%
“…However, the rise of manganese utility in the industry has led to increased manganese pollution. The imbalance of manganese homeostasis has the potential to cause neurodegenerative diseases ( 33 , 34 ). Specially, epidemiological investigations indicate that excessive exposure to manganese increases the risk of PD ( 34 , 35 , 36 ).…”
mentioning
confidence: 99%
“…The imbalance of manganese homeostasis has the potential to cause neurodegenerative diseases ( 33 , 34 ). Specially, epidemiological investigations indicate that excessive exposure to manganese increases the risk of PD ( 34 , 35 , 36 ). Multiple studies demonstrated that occupational manganese exposure during welding, mining, and other related industrial activities is associated with Parkinsonism ( 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ).…”
mentioning
confidence: 99%
“…They all cause neurotoxic effects [ 3 ]. Manganese (Mn) is another neurotoxic element of growing concern in terms of environmental overexposures [ 4 ]. Sources of human environmental exposure are diverse, from air, food, or drinking water.…”
Section: Introductionmentioning
confidence: 99%