The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level

Jovanović, Jelena Aramabašić; Mihailović, Mirjana; Uskoković, Aleksandra; Grdović, Nevena; Dinić, Svetlana; Vidaković, Melita

doi:10.3390/jof7010058

Cited by 23 publications

(16 citation statements)

References 92 publications

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“…Nevertheless, observed were effects in glycaemic control (reduction in fasting and/or 2 h postprandial glucose), lipids metabolism (decrease in total cholesterol (TC), LDL cholesterol, and/or triglycerides), some reduction in blood pressure, antioxidant effects, and a decrease in food intake with no weight change [ 75 ]. The administration of total polysaccharides extracted from P. ostreatus was given for four weeks in a high-fat diet and streptozotocin (STZ)-induced type 2 diabetic rats [ 78 ]. Elevated blood glucose levels were reduced, insulin resistance improved, and glycogen increased.…”

Section: Comorbidities and Mortality Risk Reduction Or Mitigationmentioning

confidence: 99%

Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up?

2022

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Many mushroom species are consumed as food, while significant numbers are also utilised medicinally. Mushrooms are rich in nutrients and bioactive compounds. A growing body of in vitro, in vivo, and human research has revealed their therapeutic potentials, which include such properties as anti-pathogenic, antioxidant, anti-inflammatory, immunomodulatory, gut microbiota enhancement, and angiotensin-converting enzyme 2 specificity. The uses of medicinal mushrooms (MMs) as extracts in nutraceuticals and other functional food and health products are burgeoning. COVID-19 presents an opportunity to consider how, and if, specific MM compounds might be utilised therapeutically to mitigate associated risk factors, reduce disease severity, and support recovery. As vaccines become a mainstay, MMs may have the potential as an adjunct therapy to enhance immunity. In the context of COVID-19, this review explores current research about MMs to identify the key properties claimed to confer health benefits. Considered also are barriers or limitations that may impact general recommendations on MMs as therapy. It is contended that the extraction method used to isolate bioactive compounds must be a primary consideration for efficacious targeting of physiological endpoints. Mushrooms commonly available for culinary use and obtainable as a dietary supplement for medicinal purposes are included in this review. Specific properties related to these mushrooms have been considered due to their potential protective and mediating effects on human exposure to the SARS CoV-2 virus and the ensuing COVID-19 disease processes.

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Section: Comorbidities and Mortality Risk Reduction Or Mitigationmentioning

confidence: 99%

Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up?

2022

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“…Many species of mushrooms are used as foods, and have several nutritional components that have recently gained popularity, with some of them being indicated for the treatment of diabetes and its complications. Some mushroom species have been found to contain compounds that are able to manage blood glucose levels and affect the course of diabetes complications with no harmful side effects in clinical and/or experiments ( Aramabašić Jovanović et al, 2021 ). Additionally, mechanistic investigations have led to the discovery of numerous polysaccharides in various mushroom species ( Jovanović et al, 2017 ; Aramabašić Jovanović et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Anti-hyperglycemic activity has been demonstrated in polysaccharides and their associated proteins, phytonutrients, terpenoids, and some other bioactive components obtained from the fruiting bodies of certain medicinal mushrooms, the cultured mycelium, and cultivated broth. The antidiabetic actions of these compounds are mediated through a variety of mechanisms ( Aramabašić Jovanović et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…There have been numerous reports of pre-clinical and clinical trials on the benefits of mushroom polysaccharides to human health, and polysaccharides isolated from several mushrooms have been investigated for antihyperglycemic activity, inhibition of glucose absorption, increasing β-cell mass and influence on the insulin signalling pathways ( Aramabašić Jovanović et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

Arunachalam

Sasidharan²,

Yang

2022

Front. Pharmacol.

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Diabetes mellitus is a prevalent metabolic and endocrine illness affecting people all over the world and is of serious health and financial concern. Antidiabetic medicine delivered through pharmacotherapy, including synthetic antidiabetic drugs, are known to have several negative effects. Fortunately, several natural polysaccharides have antidiabetic properties, and the use of these polysaccharides as adjuncts to conventional therapy is becoming more common, particularly in underdeveloped nations. Oxidative stress has a critical role in the development of diabetes mellitus (DM). The review of current literature presented here focusses, therefore, on the antioxidant properties of mushroom polysaccharides used in the management of diabetic complications, and discusses whether these antioxidant properties contribute to the deactivation of the oxidative stress-related signalling pathways, and to the amelioration of β-cell dysfunction and insulin resistance. In this study, we conducted a systematic review of the relevant information concerning the antioxidant and antidiabetic effects of mushrooms from electronic databases, such as PubMed, Scopus or Google Scholar, for the period 1994 to 2021. In total, 104 different polysaccharides from mushrooms have been found to have antidiabetic effects. Most of the literature on mushroom polysaccharides has demonstrated the beneficial effects of these polysaccharides on reactive oxygen and nitrogen species (RONS) levels. This review discuss the effects of these polysaccharides on hyperglycemia and other alternative antioxidant therapies for diabetic complications through their applications and limits, in order to gain a better understanding of how they can be used to treat DM. Preclinical and phytochemical investigations have found that most of the active polysaccharides extracted from mushrooms have antioxidant activity, reducing oxidative stress and preventing the development of DM. Further research is necessary to confirm whether mushroom polysaccharides can effectively alleviate hyperglycemia, and the mechanisms by which they do this, and to investigate whether these polysaccharides might be utilized as a complementary therapy for the prevention and management of DM in the future.

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“…This potential, along with the absorption and stimulatory effect of dietary fibres and gut effects on faecal excretion, makes for a promising functional food application.The effects of various MMs have also been studied with other cardiometabolic parameters.Dicks and Ellinger[68] undertook a systematic review of eight clinical studies of subjects with and without type 2 diabetes mellitus (T2DM) using fresh, cooked or dry powder P. ostreatus.These studies seemed to reveal beneficial effects, though in most studies risk of bias was high or unclear due to methodological weaknesses and/or inadequate reporting. Nevertheless, observed were effects in glycaemic control (reduction in fasting and/or 2 h postprandial glucose), lipids metabolism (decrease in total cholesterol, LDLcholesterol and/or triglycerides), some lowering in blood pressure, antioxidant effects, a reduction in food intake, but no weight change[68].Administration of total polysaccharides extracted from P. ostreatus was given for four weeks in a high-fat diet and streptozotocin (STZ)-induced type 2 diabetic rats[72]. Found was that elevatedblood glucose levels reduced, insulin resistance improved, and glycogen increased.…”

mentioning

confidence: 99%

Health promoting properties and functions of medicinal and culinary mushrooms for the COVID-19 era. An appraisal: does the “anti” mantra stack up?

Phillips¹,

Ooi²,

Pak³

2021

Preprint

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Many mushroom species are consumed as food, while significant numbers are also utilised medicinally. Mushrooms are rich in nutrients and bioactive compounds. A growing body of in vitro, in vivo, and human research has revealed their therapeutic potentials. Some of the most notable benefits include such properties as anti-pathogenic, antioxidant, anti-inflammatory, immunomodulatory, gut microbiota enhancement, and angiotensin-converting enzyme 2 specificity. The use of medicinal mushrooms (MMs) as extracts in nutraceuticals and other health products are burgeoning. COVID-19 presents an opportunity to consider how, and if, specific MM compounds might be utilised therapeutically to mitigate associated risk factors, reduce disease severity, and support recovery. As vaccines become a mainstay, MMs may have the potential as an adjunct therapy to enhance immunity. In the context of COVID-19, this review explores current research about MMs to identify the key properties claimed to confer health benefits. Considered also are barriers or limitations that may impact general recommendations on MMs as therapy. It is contended that the extraction method used to isolate bioactive compounds must be a primary consideration for efficacious targeting of physiological endpoints. Mushrooms commonly available for culinary use and obtainable as a dietary supplement for medicinal purposes are included in this review. Specific properties related to these mushrooms have been considered due to their potential mediating effects on human exposure to the SARS CoV-2 virus and the ensuing COVID-19 disease processes.

show abstract

The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level

Cited by 23 publications

References 92 publications

Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up?

Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up?

The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

Health promoting properties and functions of medicinal and culinary mushrooms for the COVID-19 era. An appraisal: does the “anti” mantra stack up?

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