The effects of magnolol supplementation on growth performance, meat quality, oxidative capacity, and intestinal microbiota in broilers

Xie, Qian; Xie, Kaihuan; Yi, Jinhui; Song, Zehe; Zhang, Haihan; He, Xi

doi:10.1016/j.psj.2022.101722

Cited by 25 publications

(30 citation statements)

References 54 publications

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“…In this research, magnolol supplementation effectively upregulated Nrf2 and NQO1 mRNA abundances in the liver of rotenone-induced broilers, indicating that dietary magnolol may improve liver antioxidant capacity through direct activation of Nrf2 pathway. Similarly, it has previously been reported that some prebiotic components of magnolol used in this research could increase Nrf2 and downstream signal gene expressions in the tissues of animals [ 15 ]. This suggested that magnolol may relieve rotenone-induced oxidative stress and liver damage through the MAPK/mTOR/Nrf2 signaling pathway.…”

Section: Discussionsupporting

confidence: 66%

“…Magnolol is one of the foremost effective ingredients of the traditional Chinese medicine Magnolia Officinalis, which has received widespread attention due to its anti-inflammatory and antioxidant effects [ 13 ]. Previous research has shown that magnolol could increase the growth performance of broilers, ducks, and laying hens via their antioxidant activity [ 7 , 14 , 15 ]. Therefore, this experiment established an oxidative stress model through intraperitoneal injection of rotenone to explore whether it can improve growth performance.…”

Section: Discussionmentioning

confidence: 99%

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Magnolol as a Protective Antioxidant Alleviates Rotenone-Induced Oxidative Stress and Liver Damage through MAPK/mTOR/Nrf2 in Broilers

et al. 2023

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This study aimed to investigate the protective effects and molecular mechanism of magnolol supplementation on rotenone-induced oxidative stress in broilers. Two hundred and eighty-eight old male AA broilers were randomly divided into four groups: the CON group: basic diet with sunflower oil injection; the ROT group: basic diet with 24 mg/kg BW rotenone; the MAG+ROT group: basic diet with 300 mg/kg magnolol and rotenone injection; and the MAG group: basic diet with 300 mg/kg magnolol and sunflower oil injection. At 21–27 days of age, the broilers in each group were intraperitoneally injected with rotenone (24 mg/kg BW) or the same volume of sunflower oil. The results showed that magnolol reversed the decrease in ADG post-injection and FBW via rotenone induction. Compared to the ROT group, MAG+ROT group enhanced the average daily gain post injection (p < 0.05). Magnolol supplement could improve the activity and mRNA expression of rotenone-suppressed antioxidant enzymes such as GSH and GSH-PX (p < 0.05). Similarly, the MDA content as an oxidative damage marker was significantly reduced after magnolol addition (p < 0.05). The hepatocyte apoptosis and the mRNA expression of apoptosis-related signaling pathway in the ROT group increased, but magnolol supplementation inhibited rotenone-induced apoptosis through the Nrf2 signaling pathway. Through RNA transcriptome analysis, there were 277 differential genes expressions (DEGs) among the CON group with ROT group, and 748 DEGs were found between the ROT group and the MAG+ROT group. KEGG pathway enrichment found that magnolol relieved rotenone-induced energy metabolism disorder and oxidative damage through signaling pathways such as MAPK and mTOR. In conclusion, magnolol attenuates rotenone-induced hepatic injury and oxidative stress of broilers, presumably by restoring hepatic antioxidant function via the MAPK/mTOR/Nrf2 signaling pathway.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Magnolol as a Protective Antioxidant Alleviates Rotenone-Induced Oxidative Stress and Liver Damage through MAPK/mTOR/Nrf2 in Broilers

et al. 2023

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“…Recently, increased serum SOD and GSH levels were observed in healthy ducklings following supplementation with magnolol [ 67 ]. A similar study reported increased GSH and SOD levels in the breast muscle and jejunum of healthy broilers in response to magnolol treatment [ 68 ]. The same increases in GSH and SOD have been observed in mice [ 69 ].…”

Section: Discussionmentioning

confidence: 98%

Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation

et al. 2022

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Lignans are known to exhibit a broad spectrum of biological activities, indicating their potential as constituents of feed supplements. This study investigated two extracts derived from the feed supplements ‘ROI’ and ‘Protect’—which contain the wood lignans magnolol and honokiol (‘ROI’), or soluble tannins additional to the aforementioned lignans (‘Protect’)—and their impact on selected parameters of intestinal functionality. The antioxidant and anti-inflammatory properties of the extracts were determined by measuring their effects on reactive oxygen species (ROS) and pro-inflammatory cytokine production in vitro. The impact on intestinal barrier integrity was evaluated in Caco-2 cells and Drosophila melanogaster by examining leaky gut formation. Furthermore, a feeding trial using infected piglets was conducted to study the impact on the levels of superoxide dismutase, glutathione and lipid peroxidation. The Protect extract lowered ROS production in Caco-2 cells and reversed the stress-induced weakening of barrier integrity. The ROI extract inhibited the expression or secretion of interleukin-8 (IL-8), interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα). Moreover, the ROI extract decreased leaky gut formation and mortality rates in Drosophila melanogaster. Dietary supplementation with Protect improved the antioxidant status and barrier integrity of the intestines of infected piglets. In conclusion, wood lignan-enriched feed supplements are valuable tools that support intestinal health by exerting antioxidant, anti-inflammatory and barrier-strengthening effects.

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“…In addition, supplementing antioxidants in the diet also has a dual effect for the commercial animals by improving meat quality and maintaining growth performance ( Xie et al, 2022 ). In Japanese quails, essential oil (EO) supplementation was found to be beneficial, and should be recommended for improving the meat quality ( Kurekci et al, 2021 ).…”

Section: Antioxidant and Meat Qualitymentioning

confidence: 99%

“…Meanwhile, butyrate, in combination with forskolin, alleviates necrotic enteritis, increases feed efficiency, and improves carcass composition of broiler chickens ( Yang et al, 2022 ). In chickens, dietary supplementation with magnolol improved meat quality with a balanced gut microbiota homeostasis of increased Faecalibacterium and decreased Coprobacillus in the cecum, and increased glutathione (GSH), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC) levels in breast muscle and jejunum ( Xie et al, 2022 ). Protocatechuic acid (PCA) increased the relative abundance of Firmicutes and Actinobacteria while reducing Bacteroidetes and Proteobacteria , thus improved the feed efficiency, growth performance, meat quality, and antioxidant capacity of broilers.…”

Section: Antioxidant and Meat Qualitymentioning

confidence: 99%

Gut microbiota and meat quality

Chen

Leng

et al. 2022

Front. Microbiol.

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Sustainable meat production is important to providing safe and quality protein sources for humans worldwide. Intensive artificial selection and high energy input into the diet of many commercial animals for the last decade has significantly increased the daily gain of body weight and shortened the raising period, but unexpectedly decreased the meat quality. The gastrointestinal tract of animals harbors a diverse and complex microbial community that plays a vital role in the digestion and absorption of nutrients, immune system development, pathogen exclusion, and meat quality. Fatty acid composition and oxidative stress in adipose and muscle tissue influences meat quality in livestock and poultry. Recent studies showed that nutraceuticals are receiving increased attention, which could alter the intestinal microbiota and regulate the fat deposition and immunity of hosts to improve their meat quality. Understanding the microbiota composition, the functions of key bacteria, and the host-microbiota interaction is crucial for the development of knowledge-based strategies to improve both animal meat quality and host health. This paper reviews the microorganisms that affect the meat quality of livestock and poultry. A greater understanding of microbial changes that accompany beneficial dietary changes will lead to novel strategies to improve livestock and poultry meat product quality.

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The effects of magnolol supplementation on growth performance, meat quality, oxidative capacity, and intestinal microbiota in broilers

Cited by 25 publications

References 54 publications

Magnolol as a Protective Antioxidant Alleviates Rotenone-Induced Oxidative Stress and Liver Damage through MAPK/mTOR/Nrf2 in Broilers

Magnolol as a Protective Antioxidant Alleviates Rotenone-Induced Oxidative Stress and Liver Damage through MAPK/mTOR/Nrf2 in Broilers

Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation

Gut microbiota and meat quality

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