The effects of magnetic fields exposure on relative permittivity of saline solutions measured by a high resolution SPR system

Abstract

A measurement system for the relative permittivity of a physiological solution under 50 Hz magnetic fields (MF) is presented. It is based on a phase-sensitive surface plasmon resonance (SPR) system. Relative permittivity was analyzed for different solute concentrations of sodium chloride under various MF exposure parameters. We found that MF exposure at 0.2–4.0 mT step-wise decreased significantly the SPR phase signal of a 0.9% sodium chloride solution while 0.1 mT of MF exposure did not. The decreases in the SPR phase signal depended on the duration of MF exposure, and the signal reached a plateau after 15 min of exposure. Interestingly, the decreased SPR phase signal showed a gradual increase and approached the background level when the exposure was drawn off. In addition, we found that the response of the sodium chloride solution to MF also depended on its concentration. In brief, the relative permittivity of sodium chloride in solutions appears to be practically affected by 50 Hz MF exposure. Our data indicates that the relative permittivity of the saline solution influenced by MF exposure should be considered when investigating the biological effects of MF exposure on organisms in experimental study.

The Relative Permittivity Changes of EGF by 50 Hz MF Exposure Neither Affect the Interaction of EGF With EGFR Nor Its Biological Effects

“…To that end, the EGF solution was exposed to MF at 4.0 mT for 1 h, and then the exposure was removed. Similar to the effect of MF exposure on SPR signals of sodium chloride in our previous study [Jiang et al, 2016], the MF‐decreased SPR signals of EGF were reversible (Fig. 3A).…”

“…For the solution of EGF (Sinobiological, Beijing, China), a non‐magnetic material with a vacuum μ r very close to 1, we can obtain the refractive index . The ELF‐MF exposure system (OX9‐1) used in this study was designed and provided by Dr. Bao [Wang et al, 2015; Jiang et al, 2016; Fei et al, 2019]. The system consists of a C‐shaped magnet enwrapped in coils, a current amplifier to provide excitation current, and a central regulator to control the field strength.…”

“…. The ELF-MF exposure system (OX9-1) used in this study was designed and provided by Dr. Bao [Wang et al, 2015;Jiang et al, 2016;Fei et al, 2019]. The system consists of a C-shaped magnet enwrapped in coils, a current amplifier to provide excitation current, and a central regulator to control the field strength.…”

Recent Progress in Optical Biosensors Based on Smartphone Platforms

“…Then et al presented an assay for quantitative detection of weak d antigen variants in blood by using the SPR technology [ 41 ]. SPR technology is also used in measuring the relative permittivity of a physiological solution [ 42 ], measuring antibodies binding to a functionalized sensing element [ 43 ], and quantitative determination of multiple tumor markers [ 44 ].…”

Characterization and Sensing of Inert Gases with a High-Resolution SPR Sensor

“…In general, the limit of detection (LOD) of the phase surface plasmon resonance (SPR) sensor is one to two orders of size lower than other plasmon sensors. Thus, it is more widely used in the field of high-sensitivity analysis [9][10][11][12][13]. Wood [14] first discovered the SPR phenomenon when studying metallic diffraction gratings.…”