The effects of magnesium sulphate on sevoflurane minimum alveolar concentrations and haemodynamic responses

Durmuş, Mahmut; But, Abdülkadir; Erdem, Tamer; Özpolat, Zekine; Ersoy, M. Özcan

doi:10.1017/s0265021505001778

Cited by 13 publications

(18 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In humans undergoing hysterectomy, MgSO 4 administration at a rate of 30 mg/ kg did not decrease the doses of propofol needed for anesthetic induction, 31 and infusion of MgSO 4 at a rate of 10 mg/kg/h did not result in significant changes in the requirement for sevoflurane in other studies. 32,33 Those studies 31-33 also corroborated findings of the present study, whereby MgSO 4 did not provide a decrease in the requirements for volatile or injectable anesthetics.…”

Section: Discussionsupporting

confidence: 87%

Effects of magnesium sulfate and propofol on the minimum alveolar concentration preventing motor movement in sevoflurane-anesthetized dogs

Johnson¹,

Seddighi²,

Rohrbach³

et al. 2016

ajvr

View full text Add to dashboard Cite

OBJECTIVE To evaluate the effect of MgSO4, alone and in combination with propofol, on the minimum alveolar concentration preventing motor movement (MACNM) in sevoflurane-anesthetized dogs. ANIMALS 6 healthy purpose-bred adult male Beagles (least squares mean ± SEM body weight, 12.0 ± 1.1 kg). PROCEDURES Dogs were anesthetized 3 times at weekly intervals. The MACNM was measured 45 minutes after induction of anesthesia (baseline; MACNM-B) and was determined each time by use of a noxious electrical stimulus. Treatments were administered as a loading dose and constant rate infusion (CRI) as follows: treatment 1, MgSO4 loading dose of 45 mg/kg and CRI of 15 mg/kg/h; treatment 2, propofol loading dose of 4 mg/kg and CRI of 9 mg/kg/h; and treatment 3, MgSO4 and propofol combination (same doses used previously for each drug). A mixed-model ANOVA and Tukey-Kramer tests were used to determine effects of each treatment on the percentage decrease from MACNM-B. Data were reported as least squares mean ± SEM values. RESULTS Decrease from MACNM-B was 3.4 ± 3.1%, 48.3 ± 3.1%, and 50.3 ± 3.1%, for treatments 1, 2, and 3, respectively. The decrease for treatments 2 and 3 was significantly different from that for treatment 1; however, no significant difference existed between results for treatments 2 and 3. CONCLUSIONS AND CLINICAL RELEVANCE MgSO4 did not affect MACNM, nor did it potentiate the effects of propofol on MACNM. Administration of MgSO4 in this study appeared to provide no clinical advantage as an anesthetic adjuvant.

show abstract

Section: Discussionsupporting

confidence: 87%

Effects of magnesium sulfate and propofol on the minimum alveolar concentration preventing motor movement in sevoflurane-anesthetized dogs

Johnson¹,

Seddighi²,

Rohrbach³

et al. 2016

ajvr

View full text Add to dashboard Cite

show abstract

“…Although the basic mechanism of analgesic effect of magnesium sulphate is unclear, it is presumed that its antagonist effect of NMDA receptors prevents the induction of central sensitization due to peripheral nociceptive stimulation and abolishes hypersensitivity. In many studies the effect of magnesium sulphate on postoperative analgesic consumption had been investigated under general anesthesia [1–9], but relatively few under spinal anesthesia [10–12]. In a previous study, Apan et al [10] used intravenous magnesium sulphate after spinal anesthesia.…”

Section: Discussionmentioning

confidence: 99%

“…Many clinical studies have demonstrated that i.v. magnesium infusion during general anesthesia reduced anesthetic requirement and postoperative analgesic consumption [1–9]. Relatively few studies have been investigated on the effects of magnesium sulphate infusion during spinal anesthesia [10–12].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Intravenous Magnesium Sulfate Infusion on Sensory Spinal Block and Postoperative Pain Score in Abdominal Hysterectomy

Kahraman

Eroğlu

2014

BioMed Research International

View full text Add to dashboard Cite

Aim. The aim of this study was to investigate the effect of i.v. infusion of magnesium sulphate during spinal anesthesia on duration of spinal block and postoperative pain. Methods. Forty ASA physical status I and status II, aged between 18 and 65, female patients undergoing abdominal hysterectomy under spinal anesthesia were enrolled in this study. Patients in the magnesium group (Group M, n = 20) received magnesium sulphate 65 mg kg−1 infusion in 250 mL 5% dextrose at 3.5 mL/min rate, and control group (Group C, n = 20) received at the same volume of saline during operation in a double-blind randomized manner. Duration of sensory and motor block, systolic, diastolic, and mean arterial blood pressures, heart rates, pain scores (VAS values), and side effects were recorded for each patient. Blood and CSF samples were taken for analysis of magnesium concentrations. Results. Regression of sensorial block was longer in Group M when compared with that in Group C (175 ± 39 versus 136 ± 32 min) (P < 0.01). The VAS scores were lower in Group M than those in Group C at the 2 time points postoperatively (P < 0.01). Conclusion. 65 mg kg−1 of magnesium sulphate i.v. infusion under spinal anesthesia prolongs spinal sensorial block duration and decreases pain VAS scores without complication in patients undergoing abdominal hysterectomy.

show abstract

“…2010), but did not decrease intraoperative sevoflurane requirements (Oguzhan et al. 2008) and actually increased its minimum alveolar concentration (MAC) at the time of skin incision (Durmus et al. 2006).…”

Section: Introductionmentioning

confidence: 98%

Effects of a constant rate infusion of magnesium sulphate in healthy dogs anaesthetized with isoflurane and undergoing ovariohysterectomy

Rioja

Dzikiti

Fosgate

et al. 2012

Veterinary Anaesthesia and Analgesia

View full text Add to dashboard Cite

The effects of magnesium sulphate on sevoflurane minimum alveolar concentrations and haemodynamic responses

Abstract: Magnesium sulphate administered before induction of anaesthesia increases MAC of sevoflurane and reduces cardiovascular responses to intubation.

Cited by 13 publications

References 25 publications

Effects of magnesium sulfate and propofol on the minimum alveolar concentration preventing motor movement in sevoflurane-anesthetized dogs

Effects of magnesium sulfate and propofol on the minimum alveolar concentration preventing motor movement in sevoflurane-anesthetized dogs

The Effect of Intravenous Magnesium Sulfate Infusion on Sensory Spinal Block and Postoperative Pain Score in Abdominal Hysterectomy

Effects of a constant rate infusion of magnesium sulphate in healthy dogs anaesthetized with isoflurane and undergoing ovariohysterectomy

Contact Info

Product

Resources

About