The Effects of Maekmoondong‐Tang on Cockroach Extract‐Induced Allergic Asthma

Park, Soo‐Jin; Sohn, Sung-Hwa; Jung, Kyung-Hwa; Lee, Kun-young; Yeom, Yu Rim; Kim, Gae-Eun; Jung, Sung Il; Jung, Hee-Jae; Bae, Hyunsu

doi:10.1155/2014/958965

Cited by 7 publications

(9 citation statements)

References 61 publications

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“…This GBT was suspended and diluted in normal saline and the rats were orally injected by an oral gavage at the concentration of 200, 400, or 600 mg/kg/day for 5 days after an oxaliplatin injection. The concentration of GBT in this study is similar to that of the other herbal formula used in our previous study [ 24 ] and that of Buja in others' study [ 16 ].…”

Section: Methodssupporting

confidence: 89%

Gyejigachulbu‐Tang Relieves Oxaliplatin‐Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation

Ahn

Kim

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Activation of spinal glial cells plays a crucial role in the pathogenesis of neuropathic pain. An administration of oxaliplatin, an important anticancer drug, often induces acute neuropathic cold hypersensitivity and/or mechanical hypersensitivity in patients. Gyejigachulbu-tang (GBT), a herbal formula comprising Cinnamomi Cortex, Paeoniae Radix, Atractylodis Lanceae Rhizoma, Zizyphi Fructus, Glycyrrhizae Radix, Zingiberis Rhizoma, and Aconiti Tuber, has been used in East Asia to treat various pain symptoms, especially in cold patients. This study investigated whether and how GBT alleviates oxaliplatin-induced cold and mechanical hypersensitivity in rats. The behavioral signs of cold and mechanical hypersensitivity were evaluated by a tail immersion test in cold water (4°C) and a von Frey hair test, respectively. The significant cold and mechanical hypersensitivity were observed 3 days after an oxaliplatin injection (6 mg/kg, i.p.). Daily oral administration of GBT (200, 400, and 600 mg/kg) for 5 days markedly attenuated cold and mechanical hypersensitivity. Immunoreactivities of glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglia marker) in the spinal dorsal horn were significantly increased by an oxaliplatin injection, which were restored by GBT administration. These results indicate that GBT relieves oxaliplatin-induced cold and mechanical hypersensitivity in rats possibly through the suppression of spinal glial activation.

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Section: Methodssupporting

confidence: 89%

Gyejigachulbu‐Tang Relieves Oxaliplatin‐Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation

Ahn

Kim

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Asthma is a well‐known chronic respiratory disease characterized by inflammatory cell infiltration, and the inflammatory cells in BALF were evidently enhanced in the allergic asthma model induced by cockroach allergen . Similarly, our study found that with overexpression of PON1, there was great relief of inflammatory cell infiltration in the submucosa and around the airway and an obvious decrease in eosinophils, mononuclear macrophages, neutrophils, lymphocytes, and total cells.…”

Section: Discussionsupporting

confidence: 77%

Influences of PON1 on airway inflammation and remodeling in bronchial asthma

Chen

Xie²,

Wang³

et al. 2017

J of Cellular Biochemistry

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This study aims to explore the influences of Paraoxonase-1 (PON1) involved in airway inflammation and remodeling in asthma. Mice were divided into control, asthma, asthma + PON1 and asthma + NC groups, and asthma models were established via aerosol inhalation of ovalbumin (OVA). HE, Masson, and PAS stains were used to observe airway inflammation and remodeling, Giemsa staining to assess inflammatory cells in bronchoalveolar lavage fluid (BALF), qRT-PCR and Western blot to detect PON1 expression, lipid peroxidation and glutathione assays to quantify malondialdehyde (MDA) activity and glutathione peroxidase (GSH) levels, ELISA to determine inflammatory cytokines and immunoglobulin, and colorimetry to detect PON1 activities. Additionally, mice lung macrophages and fibroblasts were transfected with PON1 plasmid in vitro; ELISA and qRT-PCR were performed to understand the effects of PON1 on inflammatory cytokines secreted by lung macrophages, MTT assay for lung fibroblasts proliferation and qRT-PCR and Western blot for the expressions of PON1, COL1A1, and fibronectin. After overexpression of PON1, the asthma mice had decreased inflammatory cell infiltration, fibrosis degree, and airway wall thickness; inflammatory cells and inflammatory cytokines in BALF were also reduced, expressions of OVA-IgE and IgG1, and MDA activity were decreased, but the expressions of OVA-IgG2a and INF-γ and GSH levels were increased. Besides, PON1 significantly inhibited microphage expression of LPS-induced inflammatory cytokines, lung fibroblast proliferation, and COL1A1 and fibronectin expression.Thus, PON1 could relieve airway inflammation and airway remodeling in asthmatic mice and inhibit the secretion of LPS-induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. K E Y W O R D Sairway inflammation, airway remodeling, asthma, paraoxonase-1

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“…Rats were orally injected with water extract of C. Cortex (WECC) diluted in PBS at 100, 200, or 400 mg/kg/day for five days after oxaliplatin injection. The doses of WECC used in this study were similar to those of other herbal formula used in our previous study [18,52] and those of Aconiti tuber in other’s study [48]. Rats were randomly divided into the following six groups ( n = 6 per group for cold): (1) Vehicle + PBS (i.p.…”

Section: Methodsmentioning

confidence: 96%

The Suppressive Effects of Cinnamomi Cortex and Its Phytocompound Coumarin on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats

et al. 2016

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Oxaliplatin, a chemotherapy drug, induces acute peripheral neuropathy characterized by cold allodynia, spinal glial activation and increased levels of pro-inflammatory cytokines. Herein, we determined whether Cinnamomi Cortex (C. Cortex), a widely used medicinal herb in East Asia for cold-related diseases, could attenuate oxaliplatin-induced cold allodynia in rats and the mechanisms involved. A single oxaliplatin injection (6 mg/kg, i.p.) induced significant cold allodynia signs based on tail immersion tests using cold water (4 • C). Daily oral administration of water extract of C. Cortex (WECC) (100, 200, and 400 mg/kg) for five consecutive days following an oxaliplatin injection dose-dependently alleviated cold allodynia with only a slight difference in efficacies between the middle dose at 200 mg/kg and the highest dose at 400 mg/kg. WECC at 200 mg/kg significantly suppressed the activation of astrocytes and microglia and decreased the expression levels of IL-1β and TNF in the spinal cord after injection with oxaliplatin. Furthermore, oral administration of coumarin (10 mg/kg), a major phytocompound of C. Cortex, markedly reduced cold allodynia. These results indicate that C. Cortex has a potent anti-allodynic effect in oxaliplatin-injected rats through inhibiting spinal glial cells and pro-inflammatory cytokines. We also suggest that coumarin might play a role in the anti-allodynic effect of C. Cortex.

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The Effects of Maekmoondong‐Tang on Cockroach Extract‐Induced Allergic Asthma

Cited by 7 publications

References 61 publications

Gyejigachulbu‐Tang Relieves Oxaliplatin‐Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation

Gyejigachulbu‐Tang Relieves Oxaliplatin‐Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation

Influences of PON1 on airway inflammation and remodeling in bronchial asthma

The Suppressive Effects of Cinnamomi Cortex and Its Phytocompound Coumarin on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats

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