The effects of lutein on respiratory health across the life course: A systematic review

Lent, Debora Melo van; Leermakers, Elisabeth T.M.; Darweesh, Sirwan K.L.; Moreira, Eduardo Martelli; Tielemans, Myrte J.; Muka, Taulant; Vitezova, Anna; Chowdhury, Rajiv; Bramer, Wichor M.; Brusselle, Guy; Felix, Janine F.; Jong, Jessica C. Kiefte‐de; Franco, Oscar H.

doi:10.1016/j.clnesp.2016.02.096

Cited by 33 publications

(18 citation statements)

References 46 publications

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“…Our findings are supported by randomized trials of carotenoid supplementation, specifically that of lycopene, in improving FEV 1 and exercise tolerance . Since some, but not all, studies have found an association between serum carotenoids and asthma, we speculate that inclusion of both normal‐weight and obese children with asthma in a study cohort may potentially mask the association, which we report is restricted to obese children. As carotenoids are well described to have anti‐oxidant effects, we hypothesize that their local anti‐oxidant activity may modulate airway inflammation, a hypothesis that is supported by earlier reports of a strong correlation between serum and airway carotenoid levels, suggesting that carotenoids may potentially influence airway physiology via its local concentration.…”

Section: Discussionsupporting

confidence: 76%

Carotenoids, fatty acids and disease burden in obese minority adolescents with asthma

Tobias

Wood

Rastogi

2019

Clin Experimental Allergy

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Background Paediatric obesity‐related asthma causes high disease burden, is associated with metabolic abnormalities, has few therapeutic options, and disproportionately affects urban minority children. Although poor diet quality is linked to asthma, the association of nutritional status with disease burden among children with obesity‐related asthma is not well understood. Objective To quantify nutritional status, defined as concentrations of serum carotenoids and n‐3 fatty acids, and its association with pulmonary function and metabolic markers among obese asthmatic children. Methods We quantified serum carotenoids and fatty acids in a study cohort of 158 urban minority adolescents including 39 obese asthmatics, 39 healthy weight asthmatics, 38 obese controls and 42 healthy weight controls and compared between the groups. We correlated carotenoid and fatty acid levels with pulmonary function indices and with insulin resistance and dyslipidemia. Results Mean total carotenoids were lowest in obese asthmatic children (0.41 μg/mL), lower than healthy weight asthmatics (0.52 μg/mL, P < 0.05) and healthy weight controls (0.60 μg/mL, P < 0.001). n‐6/n‐3 polyunsaturated fatty acid (PUFA) ratio also differed between the groups (P < 0.05). Total carotenoids positively correlated with per cent‐predicted FEV1 and inversely correlated with insulin resistance among obese asthmatics only. n‐6/n‐3 PUFA ratio inversely correlated with per cent‐predicted FEV1 in obese asthmatics. Conclusions & Clinical Relevance Our findings suggest that carotenoids, which are lowest in obese asthmatic children, may have protective effects on metabolic health and pulmonary function among obese asthmatic children. Similarly, n‐3 PUFA appear to be protective for pulmonary function.

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Section: Discussionsupporting

confidence: 76%

Carotenoids, fatty acids and disease burden in obese minority adolescents with asthma

Tobias

Wood

Rastogi

2019

Clin Experimental Allergy

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“…Results from Japanese study of 763 mother-infants dyads found that maternal β-carotene consumption during pregnancy in the highest quartile compared with the lowest decreased risk of infantile eczema, but not wheeze (OR 0.52, 95% CI 0.30–0.89) [ 21 ]. However, systematic review by Melo van Lent et al [ 176 ] did not find any association between lutein intake or status and respiratory health in children. A cross-sectional study of healthy, well-nourished, children aged 5.75 years ( n = 160) living in Vancouver, Canada investigating lutein intake and status did not confirm lutein role in cognition assessed by the Kaufman Assessment Battery (KABCC-II) and Peabody Picture Vocabulary Test (PPVT) [ 177 ].…”

Section: Carotenoids and Infant Health And Developmentmentioning

confidence: 99%

Health Effects of Carotenoids during Pregnancy and Lactation

Zielińska

Wesołowska

Pawlus³

et al. 2017

Nutrients

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Adequate nutrition is particularly important during pregnancy since it is needed not only for maintaining the health of the mother, but also determines the course of pregnancy and its outcome, fetus development as well as the child’s health after birth and during the later period of life. Data coming from epidemiological and interventions studies support the observation that carotenoids intake provide positive health effects in adults and the elderly population. These health effects are the result of their antioxidant and anti-inflammatory properties. Recent studies have also demonstrated the significant role of carotenoids during pregnancy and infancy. Some studies indicate a correlation between carotenoid status and lower risk of pregnancy pathologies induced by intensified oxidative stress, but results of these investigations are equivocal. Carotenoids have been well studied in relation to their beneficial role in the prevention of preeclampsia. It is currently hypothesized that carotenoids can play an important role in the prevention of preterm birth and intrauterine growth restriction. Carotenoid status in the newborn depends on the nutritional status of the mother, but little is known about the transfer of carotenoids from the mother to the fetus. Carotenoids are among the few nutrients found in breast milk, in which the levels are determined by the mother’s diet. Nutritional status of the newborn directly depends on its diet. Both mix feeding and artificial feeding may cause depletion of carotenoids since infant formulas contain only trace amounts of these compounds. Carotenoids, particularly lutein and zeaxanthin play a significant role in the development of vision and nervous system (among others, they are important for the development of retina as well as energy metabolism and brain electrical activity). Furthermore, more scientific evidence is emerging on the role of carotenoids in the prevention of disorders affecting preterm infants, who are susceptible to oxidative stress, particularly retinopathy of prematurity.

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“…Recently, there is increasing interest in understanding the possible beneficial effects of carotenoids during pregnancy and early life . In addition, there are studies in which possible association of carotenoids with the risk of developing diseases of diverse nature such as respiratory diseases and Parkinson's have been evaluated …”

Section: Importance Of Carotenoids In Agro‐food Health and Diseasementioning

confidence: 99%

“…Thus, high levels of carotenoids in the diet are usually due to healthy consumption of fruit and vegetables rich in such species. In this regard, it is sensible to argue that carotenoids are among a group of compounds that together act to protect against the development of several diseases, which are usually chronic and have important oxidative and inflammatory components …”

Section: Importance Of Carotenoids In Agro‐food Health and Diseasementioning

confidence: 99%

An Overview of Carotenoids, Apocarotenoids, and Vitamin A in Agro‐Food, Nutrition, Health, and Disease

Meléndez-Martínez

2019

Molecular Nutrition Food Res

179

126

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Carotenoids are fascinating compounds that can be converted into many others, including retinoids that also play key roles in many processes. Although carotenoids are largely known in the context of food science, nutrition, and health as natural colorants and precursors of vitamin A (VA), evidence has accumulated that even those that cannot be converted to VA may be involved in health‐promoting biological actions. It is not surprising that carotenoids (most notably lutein) are among the bioactives for which the need to establish recommended dietary intakes have been recently discussed. In this review, the importance of carotenoids (including apocarotenoids) and key derivatives (retinoids with VA activity) in agro‐food with relevance to health is summarized. Furthermore, the European Network to Advance Carotenoid Research and Applications in Agro‐Food and Health (EUROCAROTEN) is introduced. EUROCAROTEN originated from the Ibero‐American Network for the Study of Carotenoids as Functional Food Ingredients (IBERCAROT).

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The effects of lutein on respiratory health across the life course: A systematic review

Cited by 33 publications

References 46 publications

Carotenoids, fatty acids and disease burden in obese minority adolescents with asthma

Carotenoids, fatty acids and disease burden in obese minority adolescents with asthma

Health Effects of Carotenoids during Pregnancy and Lactation

An Overview of Carotenoids, Apocarotenoids, and Vitamin A in Agro‐Food, Nutrition, Health, and Disease

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