The Effects of Losartan and Enalapril Therapies on the Levels of Nitric Oxide, Malondialdehyde, and Glutathione in Patients with Essential Hypertension.

Dönmez, G; Derici, Ülver; Erbaş, Deniz; Arınsoy, Turgay; Önk, Ayhan; Sindel, Şükrü; Hasanoğlu, Enver

doi:10.2170/jjphysiol.52.435

Cited by 31 publications

(37 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results confirm the participation of the renin-angiotensin system in the endothelial dysfunction associated to hypertension, probably through its ability to generate ROS. Other investigators have also found reduction of malondialdehyde levels and plasmatic and urinary 8-isoprostrane levels as well as increase of antioxidant systems, after inhibition of the renin-angiotensin system (Mervaala et al, 2001;Donmez et al, 2002;Chamorro et al, 2004). Induction of COX-2 expression after oxidative stress stimulus in mesangial cells (Feng et al, 1995;Kiritoshi et al, 2003) and reduction of COX-2 expression in renal cortex after antioxidant treatments have been reported previously (Li et al, 2005).…”

Section: á Lvarez Et Alsupporting

confidence: 51%

Losartan Reduces the Increased Participation of Cyclooxygenase-2-Derived Products in Vascular Responses of Hypertensive Rats

Álvarez

Pérez-Girón²,

Hernanz³

et al. 2007

J Pharmacol Exp Ther

View full text Add to dashboard Cite

This study analyzes the role of angiotensin II (Ang II), via AT 1 receptors, in the involvement of cyclooxygenase (COX)-2-derived prostanoids in phenylephrine responses in normotensive rats (Wistar Kyoto; WKY) and spontaneously hypertensive rats (SHR). Aorta from rats untreated or treated for 12 weeks with losartan (15 mg/kg ⅐ day) or hydralazine plus hydrochlorothiazide (44 and 9.4 mg/kg ⅐ day, respectively) and vascular smooth muscle cells (VSMC) from SHR were used. Vascular reactivity was analyzed by isometric recording; COX-2 expression by Western blot and reverse transcription-polymerase chain reaction; prostaglandin (PG)I 2 , PGF 2␣ , 8-isoprostane, and total antioxidant status (TAS) by commercial kits; superoxide anion (O 2 . ) by lucigenin chemiluminescence; and plasmatic malondi- . production, and MDA levels were higher in SHR, but TAS was similar in both strains.Losartan, but not hydralazine-hydrochlorothiazide treatment, reduced COX-2 expression and the effect of NS-398 on phenylephrine responses in SHR. Losartan also increased TAS and reduced PGF 2␣ , PGI 2 , 8-isoprostane, and O 2 . production and MDA levels in SHR. Ang II (0.1 M) induced COX-2 expression in VSMC from SHR that was reduced by 30 M apocynin and 100 M allopurinol, NADPH oxidase, and xanthine oxidase inhibitors, respectively. In conclusion, AT 1 receptor activation by Ang II could be involved in the increased participation of COX-2-derived contractile prostanoids in vasoconstriction to phenylephrine with hypertension, probably through COX-2 expression regulation. The increased oxidative stress seems to be one of the mechanisms involved.

show abstract

Section: á Lvarez Et Alsupporting

confidence: 51%

Losartan Reduces the Increased Participation of Cyclooxygenase-2-Derived Products in Vascular Responses of Hypertensive Rats

Álvarez

Pérez-Girón²,

Hernanz³

et al. 2007

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…Factors such as advanced age, diabetes mellitus, and anemia are commonly associated with the increased oxidant stress seen in renal transplant recipients [21,22,23]. Also, statins and ACE inhibitors, which are widely used in CRF have antioxidant effects [24, 25]. Moreover, the presence of infections or chronic graft nephropathies may worsen the oxidative stress [10, 26].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Oxidative Stress in the Early Posttransplant Period: Comparison of Cyclosporine A and Tacrolimus-Based Regimens

et al. 2005

View full text Add to dashboard Cite

Background: Oxidative stress is one of the leading causes of cardiovascular morbidity and mortality in chronic kidney disease. Although it is clear that many metabolic abnormalities improve, the effects of kidney transplantation on oxidative state are obscure. Methods: Twenty-three kidney transplant patients were included in the study. Eleven patients (mean age 27.9± 9.1 years) were treated with cyclosporine A (CsA) whereas 12 patients (mean age 22.4 ± 3.4 years) were treated with tacrolimus. Twenty-three healthy subjects served as controls. None of the patients or controls suffered from diabetes mellitus or an acute infection at the time of the study. Plasma malondialdehyde (MDA), plasma selenium (Se), erythrocyte glutathione peroxidase (GSH-Px), erythrocyte superoxide dismutase (SOD), erythrocyte Zn (EZn), and erythrocyte Cu (ECu) levels were studied before and in the 1st,3rd, 7th, 14th and 28th days after the transplantation. Results: The GSH-Px, SOD, ECu, EZn and selenium levels were lower and MDA levels were higher in patients than controls before transplantation (p < 0.001 for all). MDA levels decreased and SOD, GSH-Px, ECu, EZn levels increased in parallel to the decrement of serum creatinine levels following the renal transplantation. No difference was found among the patients regarding the treatment regime. Conclusion: The study data suggest that the improvement in oxidative state parameters begins at the first day of renal transplantation and continues at the 28th posttransplant day in living donor transplantations.

show abstract

“…37 Our result was consistent with that obtained by Boveris et al and Morsy et al 38,39 In addition, a study by Donmez et al revealed that both losartan and enalapril produced a significant increase in NO and glutathione levels after 9 weeks of treatment. 40 Losartan, as one of the selective ARBs, was proved effective in enhancement the generation of antioxidant activity. This effect is related to the ability of its metabolite EXP3179 to prevent the activation of nuclear factor-κB signaling pathway which promotes the transcription of NADPH oxidase, tumor necrosis factor-α (TNF-α) and inducible (NOS) genes.…”

Section: Discussionmentioning

confidence: 99%

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

Ahmed

Abdelrahim

Abdel-Latif

2016

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

The Effects of Losartan and Enalapril Therapies on the Levels of Nitric Oxide, Malondialdehyde, and Glutathione in Patients with Essential Hypertension.

Cited by 31 publications

References 29 publications

Losartan Reduces the Increased Participation of Cyclooxygenase-2-Derived Products in Vascular Responses of Hypertensive Rats

Losartan Reduces the Increased Participation of Cyclooxygenase-2-Derived Products in Vascular Responses of Hypertensive Rats

Assessment of Oxidative Stress in the Early Posttransplant Period: Comparison of Cyclosporine A and Tacrolimus-Based Regimens

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

Contact Info

Product

Resources

About