The effects of long-term lead intoxication on the nervous system of the chicken

Mazliah, Jacob; Barron, Stephen; Bental, E; Rogowski, Zeev; Coleman, Raymond; Silbermann, M.

doi:10.1016/0304-3940(89)90541-7

Cited by 20 publications

(11 citation statements)

References 6 publications

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“…Chronic exposure to lead could cause damage to the renal, nervous, reproductive, endocrinal, and immunological systems, 75 possibly obfuscating a diagnosis of ALS in light of similar symptoms associated with other health conditions. Pure motor neuron effects after chronic exposure to lead have been observed in chickens, 76 which demonstrated motor neuron disease with characteristics similar to human ALS. 76 Lead deposition was identified in both the spinal cord and muscles in chickens exposed to lead.…”

Section: Discussionmentioning

confidence: 99%

“…Pure motor neuron effects after chronic exposure to lead have been observed in chickens, 76 which demonstrated motor neuron disease with characteristics similar to human ALS. 76 Lead deposition was identified in both the spinal cord and muscles in chickens exposed to lead. Spinal motor neuron degeneration (in the anterior horn cells), motor axonal loss, and atrophy of muscle tissue were also observed in the chickens exposed to lead.…”

Section: Discussionmentioning

confidence: 99%

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A Meta-Analysis of Observational Studies of the Association Between Chronic Occupational Exposure to Lead and Amyotrophic Lateral Sclerosis

Wang

Gomes

Cashman

et al. 2014

Journal of Occupational &Amp; Environmental Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Observational Studies of the Association Between Chronic Occupational Exposure to Lead and Amyotrophic Lateral Sclerosis

Wang

Gomes

Cashman

et al. 2014

Journal of Occupational &Amp; Environmental Medicine

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“…Lead concentration in spinal cord was 6.5μg/g. A syndrome was produced by Pb feeding, characterized by a fall in motor response amplitude, spinal motor neuron degeneration, motor axonal loss and atrophy of muscle, similar to that seen in human MND (Mazliah et al 1989).…”

Section: Als-related Metal Exposure Experiments In Animalsmentioning

confidence: 94%

Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis

Roos

Vesterberg

Syversen

et al. 2012

Biol Trace Elem Res

144

114

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Amyotrophic lateral sclerosis (ALS) is a progressive and fatal degenerative disorder of motor neurons. The cause of this degeneration is unknown, and different causal hypotheses include genetic, viral, traumatic and environmental mechanisms. In this study, we have analyzed metal concentrations in cerebrospinal fluid (CSF) and blood plasma in a well-defined cohort (n = 17) of ALS patients diagnosed with quantitative electromyography. Metal analyses were performed with high-resolution inductively coupled plasma mass spectrometry. Statistically significant higher concentrations of manganese, aluminium, cadmium, cobalt, copper, zinc, lead, vanadium and uranium were found in ALS CSF compared to control CSF. We also report higher concentrations of these metals in ALS CSF than in ALS blood plasma, which indicate mechanisms of accumulation, e.g. inward directed transport. A pattern of multiple toxic metals is seen in ALS CSF. The results support the hypothesis that metals with neurotoxic effects are involved in the pathogenesis of ALS.

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“…The owner reported no recent deaths and all chickens appeared in good health. No signs of lead poisoning such as weakness, diarrhea, or paralysis were noted [10,11]. Several environmental samples, including soil, water, and painted wood found within the chickens' coop, were collected along with an additional 21 eggs.…”

Section: Case Studymentioning

confidence: 99%