The effects of long-term ingestion of methimazole on the thyroids of rats

Owen, N.V.; Worth, H; Kiplinger, Glenn F.

doi:10.1016/s0015-6264(73)80336-0

Cited by 23 publications

(33 citation statements)

References 1 publication

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“…Tris(2,2′-bipyridine)ruthenium(II) chloride hexahydrate (Ru(bpy) 3 Cl 2 · 6H 2 O) was obtained from Aldrich. Thiamazole was purchased from Sigma.…”

Section: Experimental Chemicals and Solutionsmentioning

confidence: 99%

“…A 0.010 mol/L stock solution of Ru(bpy) 3 Cl 2 was prepared by dissolving 0.0749 g of Ru(bpy) 3 Cl 2 ·6H 2 O in 10 mL of double-distilled water, and was stored under refrigeration. A 0.010 mol/L stock solution of thiamazole was prepared by adding 0.0114 g of sample to 10 mL of double-distilled water and was also stored in the refrigerator.…”

Section: Experimental Chemicals and Solutionsmentioning

confidence: 99%

“…However, this ECL method involves the use of CdTe QDs, which is a threat to human health and the environment. In the past decade, ECL based on Ru(bpy) 3 2+ has attracted much interest from analysts and has been successfully combined with flow injection (FI) analysis, high-performance liquid chromatography, capillary electrophoresis, and micro-total analysis systems (20). To the best of our knowledge, there are not any research into the determination of thiamazole based on its ECL reaction with Ru(bpy) 3 2+ .…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, there are not any research into the determination of thiamazole based on its ECL reaction with Ru(bpy) 3 2+ . Here, the ECL behaviors of thiamazole in the presence of Ru(bpy) 3 2+ are investigated. We found that thiamazole could intensively enhance the ECL of Ru(bpy) 3 2+ in alkaline media, on the basis of which we developed a sensitive, simple and rapid FI-ECL method for the determination of thiamazole.…”

Section: Introductionmentioning

confidence: 99%

“…Here, the ECL behaviors of thiamazole in the presence of Ru(bpy) 3 2+ are investigated. We found that thiamazole could intensively enhance the ECL of Ru(bpy) 3 2+ in alkaline media, on the basis of which we developed a sensitive, simple and rapid FI-ECL method for the determination of thiamazole. The developed method has been applied to the detection of thiamazole in spiked animal feeds and satisfactory results have been obtained.…”

Section: Introductionmentioning

confidence: 99%

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Flow injection analysis of thiamazole based on strong Ru(bpy)₃²⁺ co‐reactant electrochemiluminescence

Kong

Jiang

et al. 2014

Luminescence

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Based on the strong electrochemiluminescence (ECL) reaction between thiamazole and tris(2,2'-bipyridine)ruthenium(II) (Ru(bpy)3 (2+) ), a sensitive, simple and rapid flow injection analysis method for the determination of thiamazole was developed. When a Pt working electrode was maintained at a potential of +1.50 V (vs Ag/AgCl) in pH 12.0 H3 PO4 -NaOH solution containing thiamazole and Ru(bpy)3 (2+) at a flow rate of 1.0 mL/min, a linear range of 2.0 × 10(-7) -1.0 × 10(-4) mol/L with a detection limit of 5.0 × 10(-8) mol/L was obtained for the detection of thiamazole. The method showed good reproducibility with a relative standard deviation (RSD) of 0.75%. The method has been successfully applied to the determination of thiamazole in spiked animal feeds. In addition, a co-reactant ECL mechanism was proposed for the thiamazole-Ru(bpy)3 (2+) system.

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“…Tris(2,2′-bipyridine)ruthenium(II) chloride hexahydrate (Ru(bpy) 3 Cl 2 · 6H 2 O) was obtained from Aldrich. Thiamazole was purchased from Sigma.…”

Section: Experimental Chemicals and Solutionsmentioning

confidence: 99%

Section: Experimental Chemicals and Solutionsmentioning

confidence: 99%