The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats

Garcia, Alexandra N.; Bezner, Kelsey; Depena, Christina; Yin, Wang; Gore, Andrea C.

doi:10.1016/j.yhbeh.2016.11.011

Cited by 28 publications

(36 citation statements)

References 135 publications

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“…Although sex differences were not reported in the SP test, per se, estrogen alpha and beta mRNA expression were correlated with social interaction in regions associated with social recognition, such as amygdala, dorsal septum and medial preoptic area [6]. Estrogen replacement has both prosocial or asocial effects, depending on context [16]. Further investigation of the effects of gestational exposure to CPF should more closely control for hormonal influences by monitoring the hormonal state of the female.…”

Section: Discussionmentioning

confidence: 99%

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

et al. 2019

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Background Signs of pervasive developmental disorder and social deficits were reported in toddlers and children whose mothers were exposed to organophosphate pesticides during pregnancy. Deficits in social preference were reported in adult male mice exposed to chlorpyrifos on gestational days 12–15. This study aimed (a) to test the hypothesis that adult female and male mice that were exposed prenatally to subtoxic doses of chlorpyrifos would be impaired in social behavior and (b) to determine if prenatal chlorpyrifos altered the expression of transcripts for oxytocin in the hypothalamus. Pregnant mice were treated by gavage with corn oil vehicle or 2.5 mg/kg or 5 mg/kg of CPF on gestational days 12–15. Social preference, social and non-social conditioned place preference tasks were tested in adults. Expression of oxytocin transcripts in hypothalamus was measured by qPCR. Results Chlorpyrifos (5 mg/kg on GD 12–15) reduced the innate preference for a conspecific in a dose and sex dependent manner. Adult males exposed prenatally to 5 mg/kg CPF showed a reduction in social preference. Socially conditioned place preference was impaired in offspring of dams treated with either dose of CPF. Non-social appetitive place conditioning was impaired in offspring of dams exposed to 2.5 mg/kg, but not to 5 mg/kg chlorpyrifos. Prenatal chlorpyrifos treatment did not alter the expression of the oxytocin mRNA in the hypothalamus, although expression was significantly lower in females. Conclusions Prenatal chlorpyrifos induced innate and learned social deficits and non-specific conditioning deficits in adult mice in a sex-dependent manner. Males showed specific social deficits following the higher dose whereas both males and females showed a more generalized conditioning deficit following the intermediate dose.

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Section: Discussionmentioning

confidence: 99%

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

et al. 2019

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“…2010; Wright et al. 2010) as well as in response to entering a familiar location and meeting familiar members of a group (Garcia et al. 2017).…”

Section: Discussionmentioning

confidence: 99%

“…2017). Effects of USVs are also strongly modulated by steroid hormones in adult male and female rats (Garcia et al. 2017).…”

Section: Discussionmentioning

confidence: 99%

Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats

Krishnan

Mittal

Thompson

et al. 2018

Environ Health Perspect

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“…replacement on gene expression in brain nuclei were selective and revealed the greatest number of gene changes in the supraoptic nucleus, with no genes affected in the prefrontal cortex [111].…”

Section: Neurocircuitry and Perimenopausal Psychopathologymentioning

confidence: 99%

Reproductive Aging: Perimenopause and Psychopathological Symptoms

Geršak¹,

Gersak²,

Turčin³

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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The female reproductive axis essentially comprises of the hypothalamic-pituitaryovarian axis and the mullerian-derived structures. The reproductive axis ages to a nonfunctional state (menopause) much earlier than the other organ systems do, at a time when a woman is otherwise healthy. The basis of reproductive senescence in women is oocyte depletion in the ovary. Perimenopause is defined by menstrual cycle and endocrine changes, such as disturbed ovarian-pituitary-hypothalamic feedback relationships, inaccurate estrogen levels, and decreased progesterone levels. Many psychopathological changes can take place, but most commonly women experience mild cognitive impairment, anxiety, irritability, mood swings, and depression. Estrogens influence depression and depressive-like behavior through interactions with neurotropic factors and through an influence on the serotonergic system.

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The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats

Cited by 28 publications

References 135 publications

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats

Reproductive Aging: Perimenopause and Psychopathological Symptoms

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