1996
DOI: 10.1590/s1516-31801996000100003
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The effects of long-term administration of guarana on the cognition of normal, elderly volunteers

Abstract: Paulinia cupana (guarana) is a Brazilian plant given great prestige in popular medicine, for example as being a potent stimulator of brain functions. The authors assessed the effects of the long-term administration of guarana on the cognition of normal, elderly volunteers. Forty-five volunteers were studied, with a random distribution in three experimental groups: placebo (n = 15), caffeine (n = 15), and guarana (n = 15), in a double-blind study. There were no significant cognitive alterations in these volunte… Show more

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Cited by 24 publications
(27 citation statements)
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References 11 publications
(5 reference statements)
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“…The results of our study, which found no effect of guaranà on psychological well-being, anxiety and mood, are in line with previous studies reporting no activity of guaranà [6,9]. We decided to assess the effects of guaranà on psychological well-being since the possible increase of “feelings of well-being” is among the most common claims for guaranà-containing products in particular on the Internet, where guaranà is one of the most popular herbal ingredients sought for the purpose of increasing alertness and fitness [11], however to our knowledge no scientific studies existed so far which addressed this issue.…”
Section: Discussionsupporting
confidence: 93%
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“…The results of our study, which found no effect of guaranà on psychological well-being, anxiety and mood, are in line with previous studies reporting no activity of guaranà [6,9]. We decided to assess the effects of guaranà on psychological well-being since the possible increase of “feelings of well-being” is among the most common claims for guaranà-containing products in particular on the Internet, where guaranà is one of the most popular herbal ingredients sought for the purpose of increasing alertness and fitness [11], however to our knowledge no scientific studies existed so far which addressed this issue.…”
Section: Discussionsupporting
confidence: 93%
“…In another double-blinded, cross-over study, da Costa Miranda et al [8] randomized 36 patients with breast cancer undergoing adjuvant radiation therapy to either guaranà 75 mg daily for 28 days or to placebo and found no effect on radiation-induced fatigue and depression. Fernandes Galduróz and de Araújo Carlini [9] administered 1 g of powdered guaranà (containing 2.1% caffeine) per day for five months to normal, elderly volunteers who were evaluated at baseline and after 3 and 5 months. Evaluations included the Mini-Mental State as screening for dementia, the Digital Span to assess immediate memory, the Free Recall for recent memory, Digital Symbol for psychomotor activity and concentration, Cancellation tests for vigilance and attention, the Mosaic test for visual and spatial organization, the Rave-Progressive Matrices for general abilities, and in addition quality of sleep and anxiety were assessed.…”
Section: Discussionmentioning
confidence: 99%
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“…As saponins and tannins have effects that may, directly or indirectly, affect behaviour, it is extremely likely that any effects of caffeine within guaraná are concomitant with effects of other components. It is also possible that guaraná simply has no behavioural effects as suggested by null findings (170,171) ; however, the lack of observed effects in these studies must be considered in light of a lack of effects of 25 mg caffeine, suggesting that the tasks employed may simply not be sensitive enough.…”
Section: Guaraná (Paullinia Cupana)mentioning
confidence: 86%
“…In a follow-up study the same doses and tasks were used to assess chronic (5 months) effects in an elderly population. Only one improvement was observed, a significant effect of guaraná on mosaic performance at 5 months (171) . More recently a randomised, double-blind, placebocontrolled, counterbalanced study examined the effects of a range of doses (37·5, 75, 150 and 300 mg) of guaraná (standardised to 11 % caffeine), over the course of 6 h (172) .…”
Section: Guaraná (Paullinia Cupana)mentioning
confidence: 89%