The effects of local and sustained release of fibroblast growth factor on testicular blood flow and morphology in spermatic artery— and vein-ligated rats

Guler, Fuat; Bingöl-Koloğlu, Meltem; Yağmurlu, Aydın; Güven, Cengiz; Hasırcı, Nesrin; Küçük, Özlem; Aytaç, Suat; Dindar, Hüseyin

doi:10.1016/j.jpedsurg.2004.01.038

Cited by 14 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We measured TBF using the Doppler technique, the principle of which is described in detail elsewhere [6]. In this study, 10 minutes after the onset of insufflation in the 10 and 20 mm Hg IAP groups, the mean TBF 10min values showed a significant decrease compared with their baseline values (Table 1).…”

Section: Discussionmentioning

confidence: 94%

“…Testicular blood flow was studied using the Doppler technique, the principle of which is described in detail elsewhere [6]. The parenchymal blood flow of the intratesticular arteries was assessed using color Doppler ultrasonography (ATL, Ultramark, 9-HDI, Bothell, WA, USA).…”

Section: Testicular Blood Flowmentioning

confidence: 99%

“…We would like to thank Prof Suat Aytaç, MD, for contributing data regarding the Doppler ultrasound technique to evaluate the TBF in rats [6] and Asst Prof Murat TopbaY, MD, for statistical analyses.…”

Section: Acknowledgmentsmentioning

confidence: 99%

See 2 more Smart Citations

The effects of increased intraabdominal pressure on testicular blood flow, oxidative stress markers, and morphology

İmamoğlu¹,

Çay²,

Ünsal³

et al. 2006

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

Section: Testicular Blood Flowmentioning

confidence: 99%

See 1 more Smart Citation

The effects of increased intraabdominal pressure on testicular blood flow, oxidative stress markers, and morphology

İmamoğlu¹,

Çay²,

Ünsal³

et al. 2006

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…However, the outcomes of these treatments remain unsatisfactory [8][9][10] . Endogenous opioid peptides play an important role in the intragonadal regulation of testicular function of the male rat by acting in opiate receptors that are present in Sertoli cells and by modifying the proliferative response of Sertoli cells to follicle-stimulating hormone [23] .…”

Section: Discussionmentioning

confidence: 99%

“…Several factors including decrease in testicular blood flow and oxidative stress have been supposed as mechanisms for testicular injury and various medications have been studied to prevent this testicular injury [8][9][10] . However, the results have been disappointing.…”

Section: Introductionmentioning

confidence: 99%

Effect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testis

Çakan¹,

Yılmazer

Çakan

et al. 2008

Urol Int

View full text Add to dashboard Cite

Aims: Two-stage Fowler-Stephens orchiopexy has been accompanied by testicular atrophy in some cases but neither of the mechanisms responsible for testicular injury are clear, nor is there an effective agent that might prevent this injury. In this study we aimed to investigate the long-term effects of naloxone, a morphine antagonist, on testicular histopathology and oxidative stress after spermatic vessel ligation (SVL) in rats. Methods: 32 prepubertal rats were randomly divided into four equal groups: group 1: control (only bilateral orchiectomies were performed); group 2: sham-operated group; group 3: SVL, and group 4: SVL+naloxone (1 mg/kg twice daily for 1 month). One month postoperatively, bilateral orchiectomies were performed to evaluate histopathologic findings and measurement of malondialdehyde (MDA) and nitric oxide (NO) levels. Results: Considering group 3, left SVL resulted in significant tissue damage in both testes, more severe in the ipsilateral testis. The SVL resulted in a significant increase in testicular MDA levels of both testes in this group (p < 0.05). While the ipsilateral testicular NO levels of groups 2 and 3 were significantly lower than of group 1 (p < 0.05), the contralateral testicular NO levels of all these groups were similar. After naloxone therapy, while there was no significant improvement in ipsilateral testicular histopathology (p > 0.05), the contralateral testicular histopathology improved significantly (p < 0.05). However, naloxone did not change either testicular MDA or NO levels. Conclusions: The SVL led to bilateral testicular injury, and oxidative stress may be a reason for this injury. Naloxone significantly improved contralateral testicular injury without showing any antioxidative effect.

show abstract

Micro and Nano Systems in Biomedicine and Drug Delivery

Hasırcı

Nanomaterials and Nanosystems for Biomedical Applications

View full text Add to dashboard Cite

The effects of local and sustained release of fibroblast growth factor on testicular blood flow and morphology in spermatic artery— and vein-ligated rats

Cited by 14 publications

References 33 publications

The effects of increased intraabdominal pressure on testicular blood flow, oxidative stress markers, and morphology

The effects of increased intraabdominal pressure on testicular blood flow, oxidative stress markers, and morphology

Effect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testis

Micro and Nano Systems in Biomedicine and Drug Delivery

Contact Info

Product

Resources

About