The Effects of Liposuction Removal of Subcutaneous Abdominal Fat on Lipid Metabolism are Independent of Insulin Sensitivity in Normal-Overweight Individuals

Ybarra, Juan; Blanco‐Vaca, Francisco; Fernández, Susana López; Castellví, A; Bonet, Rosa; Palomer, Xavier; Ordóñez-Llanos, Jordi; Trius, A.; Vila-Rovira, Ramón; Pérez, Antonio

doi:10.1007/s11695-007-9261-5

Cited by 54 publications

(44 citation statements)

References 48 publications

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“…This observation is in line with our hereby presented findings. However, contrary to other studies [8], these authors [51] observed a post-liposuction decrease in the serum concentrations of TAGs. Thus, it would be inappropriate to speculate if the changes taking place in humans subjected to liposuction are similar to those observed in our partially lipectomized rats.…”

Section: Discussioncontrasting

confidence: 89%

“…Taking into account the results of previous studies, namely the fact that: a) serum TAG concentrations were shown to be significantly reduced in HNF4 α mutation carriers (HNF4 +/- patients with maturity-onset diabetes of the young, MODY1) [50], and b) a significant association was observed between the liver HNF4 and DGAT1 mRNA levels, as well as between DGAT1 mRNA and plasma concentrations of TAGs in humans [42], we hypothesize that similar to the lipectomized rats, patients after liposuction may present with increased liver levels of HNF1α and HNF4α, and resultant enhancement of Mttp and Apob expressions. Ybarra et al [51] showed that liposuction of subcutaneous abdominal fat in overweight subjects results in an increase in circulating ApoB-100. This observation is in line with our hereby presented findings.…”

Section: Discussionmentioning

confidence: 99%

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Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Dettlaff-Pokora

Śledziński

Świerczyński

2015

Cell Physiol Biochem

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Background/Aims: The aim of this study was to explain the molecular basis for elevated concentrations of circulating triglycerides (TAGs) after partial surgical removal of adipose tissue (lipectomy) in rats. Methods: The levels of mRNA and protein: a) involved in synthesis of fatty acids and TAGs; b) participating in TAG-rich lipoproteins assembly and secretion; and c) transcription factors essential for maintaining TAG homeostasis were determined by RT-PCR and Western Blot in the livers of control and lipectomized rats. Results: Partial lipectomy was associated with increase: a) in serum and liver concentration of TAGs, and b) in the liver levels of mRNA of microsomal TAG transfer protein (MTP) and apolipoprotein B-100 (ApoB-100). These changes were tightly associated with up-regulation of Hnf1a and Hnf4a gene expression in the liver. Lipectomy was also reflected by a significant increase in the expression of genes encoding: a) fatty acid synthase (FASN), b) glycerol 3-phosphate acyltransferase 1 (GPAT1), diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2), c) spot 14 protein (S14) and SREBP-1 in the liver. Conclusion: Coordinated up-regulation of Mttp, Apob, Hnf1a, Hnf4a, Fasn, Gpam and Dgat (1 and 2) gene expressions may contribute to the increase in circulating and liver concentrations of TAGs after lipectomy in an experimental rat model.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Dettlaff-Pokora

Śledziński

Świerczyński

2015

Cell Physiol Biochem

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“…Subcutaneous adipose tissue removal has also been demonstrated to increase systemic circulating lipids in Syrian hamsters 26 and humans. 40 In the present study, however, IngX did not result in significant changes to portal or systemic circulating lipids. This indicates lipid spillover, in the present model, may be localized to the region of adipose depot removal.…”

Section: Discussioncontrasting

confidence: 65%

Lower body adipose tissue removal decreases glucose tolerance and insulin sensitivity in mice with exposure to high fat diet

et al. 2014

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MT Foster (2015) Lower body adipose tissue removal decreases glucose tolerance and insulin sensitivity in mice with exposure to high fat diet, Adipocyte, 4:1, 32-43, DOI: 10.4161/21623945.2014 It has been postulated that the protective effects of lower body subcutaneous adipose tissue (LBSAT) occur via its ability to sequester surplus lipid and thus serve as a "metabolic sink." However, the mechanisms that mediate this protective function are unknown thus this study addresses this postulate. Ad libitum, chow-fed mice underwent Shamsurgery or LBSAT removal (IngX, inguinal depot removal) and were subsequently provided chow (Chow; typical adipocyte expansion) or high fat diet (HFD; enhanced adipocyte expansion) for 5 weeks. Primary outcome measures included glucose tolerance and subsequent insulin response, muscle insulin sensitivity, liver and muscle triglycerides, adipose tissue gene expression, and circulating lipids and adipokines. In a follow up study the consequences of extended experiment length post-surgery (13 wks) or pre-existing glucose intolerance were examined. At 5 wks postsurgery IngX in HFD-fed mice reduced glucose tolerance and muscle insulin sensitivity and increased circulating insulin compared with HFD Sham. In Chow-fed mice, muscle insulin sensitivity was the only measurement reduced following IngX. At 13 wks circulating insulin concentration of HFD IngX mice continued to be higher than HFD Sham. Surgery did not induce changes in mice with pre-existing glucose intolerance. IngX also increased muscle, but not liver, triglyceride concentration in Chow-and HFD-fed mice 5 wks post-surgery, but chow group only at 13 wks. These data suggest that the presence of LBSAT protects against triglyceride accumulation in the muscle and HFD-induced glucose intolerance and muscle insulin resistance. These data suggest that lower body subcutaneous adipose tissue can function as a "metabolic sink."

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“…That said, however, a study that assessed only the removal of subcutaneous fat via liposuction found that there was no improvement in inflammation and NEFA concentrations (44) . This suggests that the effects seen in the study by Ybarra et al (43) , of liposuction on NEFA may be attributed to the removal of visceral as opposed to subcutaneous fat.…”

Section: Obesity In Endothelial Activationmentioning

confidence: 76%

Endothelial dysfunction associated with obesity and the effect of weight loss interventions

et al. 2011

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Endothelial damage is central to the initiation and progression of atherosclerosis, while in addition vascular endothelial cells secrete several anti-atherogenic substances including the potent vasodilator nitric oxide. Increased adhesion molecule expression, in response to pathophysiological stimuli is perhaps the earliest indicator of compromised endothelial integrity. Obesity and adiposity are associated with an increased risk of CVD, influencing disease progression via a number of mechanisms, including enhanced endothelial activation. This review discusses possible mechanisms linking adiposity and more specifically regional fat depots with endothelial function and evaluates studies investigating the effect of weight loss on endothelial function, assessed by biochemical and physiological measurements. Overall, the research to date suggests that visceral adiposity is a stronger predictor of endothelial activation than overall adiposity, possibly mediated via the action of NEFA in circulation. While in general there is a suggestion that weight loss is associated with significant improvements in endothelial function, this is not apparent in all interventions and published literature to date provides less than convincing evidence for the effects of weight loss on endothelial activation.

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The Effects of Liposuction Removal of Subcutaneous Abdominal Fat on Lipid Metabolism are Independent of Insulin Sensitivity in Normal-Overweight Individuals

Abstract: AL in healthy normal weight or slightly overweight subjects improves the major lipoprotein components of obesity-associated dyslipidemia. This improvement occurs independent of insulin sensitivity.

Cited by 54 publications

References 48 publications

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Lower body adipose tissue removal decreases glucose tolerance and insulin sensitivity in mice with exposure to high fat diet

Endothelial dysfunction associated with obesity and the effect of weight loss interventions

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