The effects of lipids on some aspects of the cellular immune response

Guillou, Pierre J.

doi:10.1079/pns19930041

Cited by 13 publications

(8 citation statements)

References 24 publications

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“…Data on DNA-synthesis by lymphocytes in response to lipids are conflicting (Guillou, 1993). Lipids reportedly augment (Kelly and Parker, 1979;Spieker-Polet & Polet 1981, diminish (Mertin & Hughes 1975Calder et al 1989;Calder & Newsholme 1992) or have no effect on lymphocyte proliferation (Tizard & Sheppard 1982).…”

Section: Discussionmentioning

confidence: 99%

Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period

et al. 2002

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A prospective randomized study on sixty patients was conducted to investigate the effects of a fish oil containing total parenteral nutrition (TPN) regimen in the postoperative period on lymphocyte subset distribution, proliferation, cytokine production and interleukin-2 receptor (IL-2R) expression. Patients who underwent large bowel surgery were divided into three groups. Nineteen patients received TPN with fish oil (0 : 2 g/kg body weight per day) plus soybean oil (1 : 0 g/kg per day), twenty patients received soybean oil (1 : 2 g/kg per day), and twenty-one patients who were on a fat-free regimen served as the control group. Natural killer (NK) cells, total, B-, T-, T 4 -, T 8 -lymphocytes, proliferation of lymphocytes, in vitro production of IL-2, IFN-g, TNF-a, and IL-2R expression were measured. Fish oil administration did not affect subset distribution and proliferation of lymphocytes. Production of interleukin-2 (IL-2), interferon g (IFN-g) and tumor necrosis factor a (TNF-a) was augmented, and IL-2R expression less enhanced compared with the controls. It is concluded that administration of 0 : 2 g/kg per day fish oil after a moderate surgical stress is not immunosuppressive, but enhances the production of IFN-g, TNF-a and possibly IL-2.

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Section: Discussionmentioning

confidence: 99%

Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period

et al. 2002

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“…17,21,22 Lipid composition and architecture of cell membranes play an important role in many aspects of cellular physiologic processes, such as fluidity of membranes, transport of ions and substrates into cells, activity of membrane-associated enzymes, receptor expression, and distribution of cytoskeletal proteins, such that their modification can result in changes in cellular functions. [23][24][25][26] Furthermore, it has been documented that fatty acid-induced biophysical changes of cell membranes can be responsible for changes of signal transduction pathways 12,27,28 or regulation of gene transcription. 8,25,29 It has been reported 17,21 that OA can reduce lymphocyte functions by modulating protein kinase C (PKC), although the mechanisms of such modulation have not been elucidated.…”

Section: Discussionmentioning

confidence: 99%

Effects on functions of ovine blood mononuclear cells for each of several fatty acids at concentrations found in plasma of healthy and ketotic ewes

Lacetera¹,

Franci²,

Scalia³

et al. 2002

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“…The immunological effect of such therapy is important since it is often administered to patients who are at risk of sepsis. Indeed, such artificial nutrition has been associated with an increased susceptibility to infection (Palmblad, 1991;Guillou, 1993;Gogos & Kalfarentzos, 1995). Our results showed that a high level of linoleic acid in the diet induced an increase in linoleic acid with a concomitant decrease in oleic acid in the phospholipid membranes.…”

Section: Discussionmentioning

confidence: 99%

Relationship between the fatty acid composition of rat lymphocytes and immune functions

et al. 2000

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The effects of dietary lipids on the fatty acid composition, activation and proliferation of lymphocytes were investigated. Weanling male Wistar rats were fed for 8 weeks on one of two low-fat diets which contained 50 g lipid/kg, or one of two high-fat diets containing 200 g lipid/kg, from either coconut oil or soyabean oil. The fatty acid composition of phospholipids from splenocyte membranes was affected by dietary lipid manipulation, and these differences influenced lymphocyte functions. Increased levels of linoleic acid in spleen lymphocytes correlated negatively with interleukin-2 receptor α-chain expression determined either by measuring the mean fluorescence or by the proportion of cells staining positive for CD25, and with the cell proliferation index. However, we found a positive correlation between interleukin-2 receptor α-chain expression determined by measuring the mean fluorescence and the cell proliferation index with the oleic acid concentration of spleen lymphocytes. Since phospholipid hydrolysis occurs early in lymphocyte activation, immunosuppressive effects induced by polyunsaturated fatty acids, described in the literature, could be due to an increase of linoleic acid or a decrease of oleic acid affecting many components of plasma-membrane-associated events involved in lymphocyte activation.

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The effects of lipids on some aspects of the cellular immune response

Cited by 13 publications

References 24 publications

Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period

Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period

Effects on functions of ovine blood mononuclear cells for each of several fatty acids at concentrations found in plasma of healthy and ketotic ewes

Relationship between the fatty acid composition of rat lymphocytes and immune functions

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