The effects of lesions in the frontal or posterior association cortex of rats on maze III

Thomas, Roger K.; Weir, Vender Knowles

doi:10.3758/bf03337507

Cited by 35 publications

(20 citation statements)

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“…It should be mentioned that the parietal ablations seen here tended to be located primarily in the most rostral portions of the parietal cortex and sometimes included portions of somatosensory area I. The frontopolar lesions conformed to those studied by Thomas and Weir (1975). A Wilcoxon and Wilcox multiple comparisons analysis was performed on the ranked cortical lesion sizes, but statistically significant group differences were not seen.…”

Section: Resultssupporting

confidence: 56%

Temporal and parietal association cortex lesions and spatial and black-white reversal learning in the rat

McDaniel

Thomas

1978

Psychobiology

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In Experiment 1, rats with parietal, temporal, or frontopolar neocortex ablations and nonoperated controls were trained on seven spatial reversals. The animals with parietal association cortex damage were found to be deficient on this task compared to all other groups. In Experiment 2, rats with either temporal or striate neocortical ablations or subcortical lesions of the lateroposterior thalamic nucleus and nonoperated controls were trained on a black-white reversal task. The rats with temporal damage committed significantly more errors than all other groups. These results together with those of previous research suggest that a dissociation exists between the effects of parietal and temporal association cortex ablations on reversal learning in the rat. It was suggested that the visual functions of the temporal association cortex might be mediated by connections with either the striate cortex or the lateroposterior thalamic nucleus.

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Section: Resultssupporting

confidence: 56%

Temporal and parietal association cortex lesions and spatial and black-white reversal learning in the rat

McDaniel

Thomas

1978

Psychobiology

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“…Early studies on the role of the APC in rodents were mainly motivated by the issue of whether there is some functional homology between the posterior parietal lobes in primates and the parietal cortex in rodents (Thomas and Weir, 1975;Boyd and Thomas, 1977). In humans, damage to the posterior parietal lobes induces a complex syndrome made of a constellation of cognitive deficits in numerous spatial abilities (reviewed in Lynch, 1980).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal-parietal cortical interactions in spatial cognition

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Poucet

2000

Hippocampus

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Growing evidence suggests that the associative parietal cortex (APC) of the rat is involved in the processing of spatial information. This observation raises the issue of the respective functions of the APC and the hippocampus in spatial processing as well as of their possible interactions. In this paper, we review neuroanatomical, electrophysiological, and behavioral data that support the existence of such functional interactions. Our hypothesis is that the APC is involved in the initial combination of visuospatial information and self‐motion information necessary for the integration of egocentrically acquired information into allocentrically coded information, the latter step being completed in the hippocampus. The dialogue between the hippocampus and the APC is therefore crucial, particularly when the elaboration and/or updating of an allocentric representation depends on complex combinations of visuospatial and self‐motion information. Hippocampus 10:491–499, 2000 © 2000 Wiley‐Liss, Inc.

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“…Rats with similarly localized corticallesions are known to be deficient in place learning, as gauged by performance on simple (Lashley, 1929;Thompson, 1983) and complex (Lashley, 1929;Thomas & Weir, 1975;Thompson, 1979) maze habits. Furthermore, an extensive series of experiments comparing the effects of occipital lesions with those of hippocampal lesions on a wide variety of laboratory tasks led to the conclusion that the nonvisual function of the former was closely associated with the spatial functions of the latter (Thompson, 1982), a conclusion that must be revised in light of the present findings.…”

Section: Performance On Trials 2-5: a Measure Of Detour Habit Formationmentioning

confidence: 99%

Detour problem-solving behavior in rats with neocortical and hippocampal lesions: A study of response flexibility

1984

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Young rats previously subjected to discrete neocortical ablations or hippocampal electrolytic lesions received five trials on each of three "climbing" detour problems. Performance on Trial! (a measure of response flexibility) of each problem was significantly impaired in those groups with frontal, parietal, or hippocampallesions; the group with occipitallesions was impaired on only one problem. Performance on Trials 2-5(a measure of detour habit formation) of each problem was significantly impaired only in the hippocampal group; the neocortical groups showed either no impairment or a mild impairment on these trials. These results suggest that the solution of detour problems on the first trial may require a cognitive process that is qualitatively different from that required on subsequent trials.

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The effects of lesions in the frontal or posterior association cortex of rats on maze III

Cited by 35 publications

References 13 publications

Temporal and parietal association cortex lesions and spatial and black-white reversal learning in the rat

Temporal and parietal association cortex lesions and spatial and black-white reversal learning in the rat

Hippocampal-parietal cortical interactions in spatial cognition

Detour problem-solving behavior in rats with neocortical and hippocampal lesions: A study of response flexibility

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