The effects of left DLPFC tDCS on emotion regulation, biased attention, and emotional reactivity to negative content

Clarke, Patrick; Bockstaele, Bram Van; Marinovic, Welber; Howell, Joel; Boyes, Mark; Notebaert, Lies

doi:10.3758/s13415-020-00840-2

Cited by 37 publications

(36 citation statements)

References 49 publications

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“…Amongst them, we did not receive a response from the corresponding author about the missing data in one study [ 43 ], and the authors of other study were unable to provide data until three months later due to isolation [ 69 ]. Finally, 17 studies were included in the meta-analysis [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ]. Each of included studies had the condition of downregulate negative emotions in study procedure, but two of them did not have the condition of maintenance of negative emotions [ 53 , 77 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, 150 of the participants had a psychiatric disorder, including 39 with AUD, 39 with depression, 33 with internet gaming disorder, and 39 with OCD, while the other participants were healthy. Four studies used HF-rTMS [ 47 , 51 , 52 , 70 ], of which one study used LF-rTMS also [ 52 ], one study used single-pulse TMS [ 48 ], one study used cTBS [ 49 ], and 11 studies used tDCS [ 50 , 53 , 54 , 55 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ]. Materials from the above studies included pictures or emotional stimulus which only induced negative emotions.…”

Section: Resultsmentioning

confidence: 99%

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The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Zhang

Liu

et al. 2022

Brain Sciences

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(1) Background: Emotion regulation (ER) is regarded as a core treatment target for depression and other mental illnesses. In recent years, non-invasive brain stimulation (NIBS) has been extensively used as an intervention for mental illnesses, but there has been no systematic review conducted regarding its effect on emotion regulation. Therefore, we conducted a meta-analysis of the effectiveness of NIBS for emotion regulation; (2) Methods: Systematic searches were conducted in Embase, Web of Science, PubMed, and Cochrane Library. We analyzed the effects of NIBS on tasks assessing emotion regulation using a random-effects model, and further explored the moderating role of the following factors on transcranial direct current stimulation (tDCS) studies by conducting subgroup analyses and meta-regression: target electrode placement, return electrode placement, current intensity, target electrode size, and duration of intervention; (3) Results: A total of 17 studies were included. Our meta-analysis indicated a small but significant effect of NIBS on the downregulation of negative emotions. Separate analyses indicated that repetitive transcranial magnetic stimulation (rTMS) had a medium and significant effect on the downregulation of negative emotions, whereas tDCS had no significant effect. Subgroup analyses showed that the effect of tDCS was moderated by target and return electrode placemen; (4) Conclusions: These results indicate that NIBS had a positive effect on the downregulation of negative emotions. The stimulation protocols should be carefully considered and the underlying mechanisms should be further explored.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Zhang

Liu

et al. 2022

Brain Sciences

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“…Also in line with these results, Marques et al 29 reported a decrease in emotional reactivity to negative pictures under tDCS of the left ventrolateral prefrontal cortex (vlPFC) in combination with cognitive reappraisal. However, bilateral tDCS of the dlPFC did not increase efficacy of cognitive reappraisal 29 an effect also reported by a recent study from Clarke et al 30 . Vieira et al 31 even reported diminished emotion regulation ability during tDCS of the left vlPFC.…”

Section: Introductionsupporting

confidence: 66%

Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation

Doerig

Seinsche

Moisa

et al. 2021

Sci Rep

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Reappraisal of negative memories and experiences is central for mental health and well-being. Deficiency of reappraisal lies at the core of many psychiatric disorders and is a key target for treatment. Here we apply transcranial direct current stimulation (tDCS) to enhance reappraisal of negative emotional memories. In a randomised, sham-controlled, 2 × 2 between-subject and double-blinded study, we applied single sessions of anodal and sham tDCS over the right dorsolateral prefrontal cortex (dlPFC) of 101 healthy participants while reappraising a personal negative memory or engaging in a control task. We hypothesised that (i) reappraisal decreases negative valence, arousal and evaluations of the memory and leads to improved decision making, and (ii) tDCS leads to additional changes in these reappraisal outcomes. In line with these hypotheses, participants’ personal memories were rated as less negative and less arousing following reappraisal. Anodal tDCS during reappraisal was associated with significant short-term reductions in negative valence compared to sham stimulation. Our results indicate that tDCS may enhance some of the effects of reappraisal. If replicated, our findings suggest potential benefits elicited by tDCS stimulation that may help optimise current treatment approaches for psychiatric disorders.

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“…The conventional mass univariate activation and connectivity analyses revealed that AT1R blockade specifically attenuated left dlPFC reactivity and amygdala-vACC connectivity in response to fearful oddballs. The dlPFC represents a functionally heterogenous region and has been involved in several domains related to fear processing, including implicit and explicit cognitive regulation of negative affect and task-irrelevant distractors (Beauregard, Lévesque, & Bourgouin, 2001; Delgado, Nearing, LeDoux, & Phelps, 2008; Kim & Hamann, 2007; Lévesque et al, 2003; C. Liu et al, 2021; Ochsner, Bunge, Gross, & Gabrieli, 2002; Ochsner et al, 2004; Phan et al, 2004; Zhuang et al, 2021) rapid attention towards salient stimuli, including threat-related stimuli (Clarke et al, 2020; Peers, Simons, & Lawrence, 2013; Sagliano, D’Olimpio, Izzo, & Trojano, 2017) and the conscious subjective experience of emotional states including fear (Kroes et al, 2019; LeDoux & Pine, 2016). In accordance with this functional characterization of the dlPFC in neuroimaging studies lesion and non-invasive brain stimulation studies have provided more causal evidence for an involvement in the fear-related process.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin II regulates the neural expression of subjective fear in humans - precision pharmaco-neuroimaging approach

Zhang

Zhao

et al. 2022

Preprint

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There has been growing interest in using pharmacological fMRI to identify novel treatments for fear, yet these models are limited with respect to determining process-specific effects on the actual subjective experience of fear which represents the key symptom why patients seek treatment. Combining a selective angiotensin II type 1 receptor (ATR1) antagonist with a fear vigilance fMRI paradigm and neurofunctional decoding in n = 87 individuals we demonstrate that AT1R blockade selectively reduces the neurofunctional reactivity to fear-inducing visual oddballs in terms of attenuating dorsolateral prefrontal activity and amygdala-ventral anterior cingulate (vACC) communication, and further show that the observed effect is due to reduced subjective fear, but not threat or non-specific negative affect, using a decoding analysis. Our findings demonstrate a highly specific role of AT1R in subjective fear experience and demonstrate the feasibility of a precision approach to the affective characterization of novel receptor targets for fear in humans.

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The effects of left DLPFC tDCS on emotion regulation, biased attention, and emotional reactivity to negative content

Cited by 37 publications

References 49 publications

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation

Angiotensin II regulates the neural expression of subjective fear in humans - precision pharmaco-neuroimaging approach

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