The effects of laser irradiation on Trichophyton rubrum growth

Vural, Emre; Winfield, Harry L.; Shingleton, Alexander W.; Horn, Thomas; Shafirstein, Gal

doi:10.1007/s10103-007-0492-4

Cited by 111 publications

(113 citation statements)

References 25 publications

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“…The various concentrations were incubated for 30 minutes at 30 C in an orbital shaker (200 rpm) (Ratek, Boronia, VIC, Australia). Three experiments were performed and all the samples were performed in triplicate (n ¼ 9).…”

Section: Rb Dark Toxicitymentioning

confidence: 99%

An in vitro study of the photodynamic effect of rose bengal on trichophyton rubrum

Cronin

Moffitt

Mawad

et al. 2012

Journal of Biophotonics

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Onychomycosis, a fungal infection of the finger or toenails, is predominantly caused by Trichophyton rubrum. Treatment is difficult due to high recurrence rates and problems with treatment compliance. For these reasons, alternative therapies are needed. Here we describe the photoactivation of Rose Bengal (RB) using a green laser (λ = 532 nm) at fluences of 68, 133 and 228 J/cm(2) , and assess its fungicidal activity on T. rubrum spore suspensions. A 140 µM RB solution was able to induce a fungicidal effect on T. rubrum when photosensitized with the fluence of 228 J/cm(2) . RB photosensitization using a green laser provides a potential novel treatment for T. rubrum infections.

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Section: Rb Dark Toxicitymentioning

confidence: 99%

An in vitro study of the photodynamic effect of rose bengal on trichophyton rubrum

Cronin

Moffitt

Mawad

et al. 2012

Journal of Biophotonics

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“…In 2008, Vural et al [13] reported that T. rubrum growth was inhibited by laser irradiation. Another in vitro study also indicated that LPNYL can effectively inhibit the growth of T. rubrum [14].…”

Section: Discussionmentioning

confidence: 99%

The Energy Density and Treatment Times Are the Main Factors That Affect the Efficacy of Long-Pulsed 1,064-nm Nd:YAG Laser Treatment for Onychomycosis Caused by Trichophyton rubrum

Liu¹,

Zhang²,

Zeng³

et al. 2018

Dermatology

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Background: No optimal regimen exists for the LPNYL (long-pulsed 1,064-nm neodymium:yttrium-aluminum-garnet laser) for treating onychomycosis. Objective: To establish an optimal LPNYL treatment regimen for onychomycosis caused by Trichophyton rubrum (OCTr). Patients and Methods: First, 511 infected nails of 177 patients were treated using LPNYL with orthogonally designed regimens according to various energy densities, spot sizes, pulse widths, and treatment times. The optimal treatment regimen was established by multivariate analysis. Next, 69 patients with 221 infected nails were randomized to receive oral itraconazole (drug group) and the optimal regimen of LPNYL treatment (laser group). The clinical efficacy (CE) and mycological efficacy (ME) were evaluated at 6 and 12 months following the start of treatment, and adverse reactions were recorded in both groups. Results: Both CE and ME were significantly correlated with the energy density (p < 0.05) and treatment times (p < 0.05), but not with the spot size (0.071 0.05), and no significant difference was observed in CE at 12 months between the two groups (p > 0.05). At 6 months, the CE in the laser group was significantly higher than that in the drug group (p < 0.001). Conclusions: LPNYL is effective and safe for treating OCTr. The energy density and treatment times are the main factors that affect the efficacy. The optimal regimen for LPNYL is an energy density of 45 J/cm², pulse width of 35 ms, spot size of 4 mm, frequency of 1 Hz, and 6 treatments with 1-week intervals. Laser treatment has rapid clinical recovery.

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“…Bierze się także pod uwagę zarówno bezpośrednie działanie przeciwgrzybicze -apoptozę indukowaną temperaturą, jak i wpływ na miejscowy układ immunologiczny [9,10]. Vural i wsp.…”

Section: Promieniowanie Laserowe W Leczeniu Grzybicy Paznokciunclassified

“…Vural i wsp. [10] uważają, że promieniowanie o długości 532 nm jest absorbowane przez czerwony barwnik, obecny w T. rubrum, co prowadzi do niszczenia kolonii. Z kolei światło o długości 1064 nm może być absorbowane przez melaninę, która jest obecna w ścianie wielu grzybów [11].…”

Section: Promieniowanie Laserowe W Leczeniu Grzybicy Paznokciunclassified

Novel light therapies in treatment of onychomycosis

Erkiert‐Polguj¹,

Algiert²,

Rotsztejn³

2016

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Przegląd Dermatologiczny 2016/3 246 STRESZCZENIE Grzybica paznokci jest częstą chorobą dotyczącą aparatu paznokciowego, a jej leczenie wg obecnie obowiązujących standardów nie zawsze przynosi zadowalające efekty. Celem pracy jest zwrócenie uwagi na nowe możliwości terapii z wykorzystaniem promieniowania laserowego, promieniowania ultrafioletowego typu C, a także terapii fotodynamicznej. Najwięcej danych piśmiennictwa dotyczy wykorzystania lasera neodymowo-yagowego, a także laserów diodowych lub ablacyjnego lasera dwutlenkowo-węglowego. Niektórzy autorzy, aby poprawić skuteczność leczenia, stosowali przed zabiegiem usuwanie mas grzybiczych lub dołączali miejscowe leczenie preparatami przeciwgrzybiczymi. Ponadto przedstawiono metodę fotodynamiczną wykorzystywaną w leczeniu stanów przednowotworowych i powierzchownych nowotworów skóry, która daje obiecujące wyniki w terapii grzybicy paznokci z zastosowaniem tych samych lub innych fotouczulaczy. Uzyskane przez autorów efekty leczenia i brak poważnych działań ubocznych zachęcają do stosowania tego typu terapii, ale żadna z metod do tej pory nie została porównana z leczeniem farmakologicznym wg aktualnych wytycznych. ABSTRACTOnychomycosis is a frequent nail disease. Standard treatment is not sufficient in some patients. The aim of the study is to provide an overview of laser, UVC and photodynamic therapy of onychomycosis. The use of Nd:YAG laser is described in many articles, and also diode lasers and ablative CO 2 are used. Some authors, in order to improve the efficiency of treatment, also administered topical antifungal therapy or removed a part of the nail. Also photodynamic therapy usually used in precancerous diseases or superficial skin tumors is also employed in onychomycosis with the same or new photosensitizers. The results and the lack of serious side effects encourage the use of these methods, although none has been compared to standard oral therapy. SŁOWA KLUCZOWE:terapia fotodynamiczna, laser, grzybica paznokci, UVC.

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The effects of laser irradiation on Trichophyton rubrum growth

Cited by 111 publications

References 25 publications

An in vitro study of the photodynamic effect of rose bengal on trichophyton rubrum

An in vitro study of the photodynamic effect of rose bengal on trichophyton rubrum

The Energy Density and Treatment Times Are the Main Factors That Affect the Efficacy of Long-Pulsed 1,064-nm Nd:YAG Laser Treatment for Onychomycosis Caused by <b><i>Trichophyton rubrum</i></b>

Novel light therapies in treatment of onychomycosis

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