The Effects of L- and D-Stereoisomers on the Transmitter Secretion and Ionic Currents in the Motor Nerve Ending

Gasotransmitters: Physiology and Pathophysiology

“…Most NOSs are activity-dependent because of their Ca 2+ dependency (Bredt and Snyder 1992a). The substrate of NO synthesis-L-arginine imitated the effect on NO and decreased the evoked transmitter release in NMJ, while the inhibitors of NOS-L-NAME or 3Br7NiNa had the opposite effect (Thomas and Robitaille 2001;Zefirov et al 2002;Sitdikova et al 2003). The substrate of NO synthesis-L-arginine imitated the effect on NO and decreased the evoked transmitter release in NMJ, while the inhibitors of NOS-L-NAME or 3Br7NiNa had the opposite effect (Thomas and Robitaille 2001;Zefirov et al 2002;Sitdikova et al 2003).…”

“…Regulation of vesicle fusion dependent on frequency and kinetics is, however, improbable as the frequency of miniature EPPs and the quantal content of neuromuscular transmission were not affected by NO-donors at the rat diaphragm (Mukhtarov et al 2000). L-arginine may be involved in the inhibitory action of NOS by substrate-enzyme inhibition (Castellano et al 2001;Sitdikova et al 2003) or exert NO-independent effects. The differences concerning of L-arginine action on Ach release in rat NMJ may be linked to the concentration of this amino acid used in the experiments.…”