The effects of joint damage on muscle function, proprioception and rehabilitation

Hurley, MV

doi:10.1054/math.1997.0281

Cited by 157 publications

(122 citation statements)

References 0 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…Patients with unstable medical conditions, precluding safe participation in an exercise program, are excluded from clinical trials (10)(11)(12)(13), because of the high risk of comorbidity-induced adverse events. One study investigated the outcome of exercise therapy in a subgroup of patients with knee OA and comorbidity compared to patients without comorbidity (14).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Tailored Exercise Therapy on Physical Functioning in Patients With Knee Osteoarthritis and Comorbidity: A Randomized Controlled Trial

MSc

Leeden

Cheung

et al. 2017

Arthritis Care & Research

104

100

View full text Add to dashboard Cite

Objective. To evaluate the efficacy on physical functioning and safety of tailored exercise therapy in patients with knee osteoarthritis (OA) and comorbidities. Methods. In a randomized controlled trial, 126 participants were included with a clinical diagnosis of knee OA and at least 1 of the following target comorbidities: coronary disease, heart failure, type 2 diabetes mellitus, chronic obstructive pulmonary disease, or obesity (body mass index ‡30 kg/m 2 ), with severity score ‡2 on the Cumulative Illness Rating Scale. The intervention group received a 20-week, individualized, comorbidity-adapted exercise program consisting of aerobic and strength training and training of daily activities. The control group received their current medical care for knee OA and were placed on a waiting list for exercise therapy. Primary outcome measures were the Western Ontario and McMaster Universities Osteoarthritis Index, subscale physical functioning (WOMAC-pf), and the 6-minute walk test (6MWT). Measurements were performed at baseline, after 20 weeks (directly posttreatment), and at 3 months posttreatment. Results. Statistically significant physical functioning differences over time were found between the intervention and control group (WOMAC: B 5 27.43 [95% confidence interval (95% CI) 29.99, 24.87], P < 0.001; and 6MWT: B 5 34.16 [95% CI 17.68, 50.64], P < 0.001) in favor of the intervention group. At 3 months followup, the mean improvements in the intervention group were 33% on the WOMAC scale and 15% on the 6MWT. These improvements are of clinical relevance. No serious adverse events occurred during the intervention. Conclusion. This is the first study showing that tailored exercise therapy is efficacious in improving physical functioning and safe in patients with knee OA and severe comorbidities.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficacy of Tailored Exercise Therapy on Physical Functioning in Patients With Knee Osteoarthritis and Comorbidity: A Randomized Controlled Trial

MSc

Leeden

Cheung

et al. 2017

Arthritis Care & Research

104

100

View full text Add to dashboard Cite

show abstract

“…Decreased levels of physical activity [54][55][56], weightbearing status [56][57][58], and immobilization [59][60][61] can lead to progressive atrophy. Several factors including decreased protein synthesis [62][63][64], increased levels of plasma cortisol [65], arthrogenic inhibition [66,67], and altered afferent inflow [66] may be responsible for atrophy after trauma or in periods of prolonged muscular disuse. Though evidence is lacking, this notion alone supports the possible benefits of prehabilitation in preoperative ACL-deficient patients.…”

Section: Causes Of Quadriceps Weaknessmentioning

confidence: 99%

“…Most studies failed to show a relation between quadriceps muscle CSA, morphological measures, and muscle strength in ACL-deficient patients [66,68,69]. Muscle volume appears to be a better indicator for atrophy than muscle torque because the latter is patient-dependent [70].…”

Section: Causes Of Quadriceps Weaknessmentioning

confidence: 99%

Prehabilitation: The Void in the Management of Anterior Cruciate Ligament Injuries—A Clinical Review

Shaarani

Moyna

Moran

et al. 2012

ISRN Rehabilitation

View full text Add to dashboard Cite

The rehabilitation of patients undergoing anterior cruciate ligament (ACL) reconstruction requires symmetry in bilateral quadriceps strength and adequate proprioception capabilities prior to return to preoperative level of activity or sport. This is the limiting factor and can delay the time that patients can return to play. There is little literature on pre-operative physiotherapy or prehabilitation of patient with ACL injury. This paper discusses the anatomy, biomechanics, surgical decision making, and the current knowledge of preoperative training or "prehabilitation" in patients awaiting ACL reconstruction.

show abstract

“…In humans, clinical studies have described joint conditions that are accompanied by inflammation [10][11][12] and that have been related to significant muscle changes, such as atrophy.…”

Section: Introductionmentioning

confidence: 99%

“…Muscle atrophy is a highly regulated and ordered process resulting in reduced muscle fiber crosssectional area (CSA), protein content and force 8,11 , increased fatigue and insulin resistance 9 , and the transformation of type I fibers into type II fibers 8,9 . In rats and humans, molecular changes have been detected during muscle atrophy, including up-regulation of two E3 ubiquitin ligases, i.e.…”

Section: Introductionmentioning

confidence: 99%

Effect of tibiotarsal joint inflammation on gene expression and cross-sectional area in rat soleus muscle

Ramírez¹,

Russo²,

Delfino³

et al. 2013

Braz. J. Phys. Ther.

View full text Add to dashboard Cite

| Background: Joint inflammation is a common clinical problem in patients treated by physical therapists. The hypothesis of this study is that joint inflammation induces molecular and structural changes in the soleus muscle, which is composed mainly of slow-twitch muscle fibers. Objective: To study the effect of tibiotarsal joint inflammation on muscle fiber cross-sectional area (CSA), gene expression levels (atrogin-1, MuRF1, MyoD, myostatin, p38MAPK, NFκB, TNF-alpha), and TNF-alpha protein in the soleus muscle. Method: Wistar rats were randomly divided into 3 periods (2, 7 and 15 days) and assigned to 4 groups (control, sham, inflammation, and immobilization). Results: In the inflammation group at 2 days, MuRF1 and p38MAPK expression had increased, and NFκB mRNA levels had decreased. At 7 days, myostatin expression had decreased. At 7 and 15 days, this group had muscle fiber CSA reduction. At 2 days, the immobilization group showed increased atrogin-1, MuRF1, NFκB, MyoD, and p38MAPK expressions and reduced muscle fiber CSA. At 7 and 15 days, myostatin mRNA levels had increased, and the CSA had decreased. The sham group showed increased p38MAPK and myostatin expressions at 2 and 7 days, respectively. No changes occurred in TNF-alpha gene or protein expression. Conclusion: Acute joint inflammation induces gene expression related to the proteolytic pathway without reduction in muscle fiber CSA. Chronic joint inflammation induced muscle atrophy without up-regulation of important genes belonging to the proteolytic pathway. Thus, muscle adaptation may differ according to the stage of joint inflammation, which suggests that the therapeutic modalities used by physical therapists at each stage should also be different.Keywords: skeletal muscle; joint disease; gene expression; muscle plasticity; physical therapy; rehabilitation. HOW TO CITE THIS ARTICLERamírez C, Russo TL, Delfino G, Peviani SM, Alcântara C, Salvini TF. Effect of tibiotarsal joint inflammation on gene expression and cross-sectional area in rat soleus muscle. Braz J Phys Ther. 2013 May-June; 17(3):244-254. http://dx

show abstract

The effects of joint damage on muscle function, proprioception and rehabilitation

Cited by 157 publications

References 0 publications

Efficacy of Tailored Exercise Therapy on Physical Functioning in Patients With Knee Osteoarthritis and Comorbidity: A Randomized Controlled Trial

Efficacy of Tailored Exercise Therapy on Physical Functioning in Patients With Knee Osteoarthritis and Comorbidity: A Randomized Controlled Trial

Prehabilitation: The Void in the Management of Anterior Cruciate Ligament Injuries—A Clinical Review

Effect of tibiotarsal joint inflammation on gene expression and cross-sectional area in rat soleus muscle

Contact Info

Product

Resources

About