The effects of isotretinoin on wisdom tooth extraction

Effect of exogenous retinoic acid on tooth movement and periodontium healing following tooth extraction in a rat model

“…In the present study, none of the animals experienced any complications, such as alveolar osteitis or dry socket. A study evaluating the effect of isotretinoin on wisdom tooth extraction also showed that the post‐operative complications were not associated with the use of this drug . Taken altogether, our findings indicate that dental extractions for orthodontic purpose may not represent a problem with the concomitant use of isotretinoin.…”

“…Although exogenous retinoic acids have been thoroughly investigated, studies to date have shown conflicting results on the effect of isotretinoin on the bone metabolism and gingival wound healing . Clarification of this issue would help us to answer some clinical questions such as should patients who take this medication on a daily basis temporarily avoid orthodontic treatment?…”

Should isotretinoin be stopped prior to surgery? A Critically Appraised Topic

“…Sharma et al 23 describe a historical cohort study of 339 patients treated with isotretinoin (no dose information provided). Patients were sent questionnaires to determine how many had undergone wisdom tooth extraction while on the medication or within 3 months of its discontinuation.…”

Indications and Use of Isotretinoin in Facial Plastic Surgery

“…43 These observations are in line with the study conducted by Sharma et al who detected a slight increase in alveolar osteitis after wisdom tooth extraction. 4 Furthermore, severe cases of rhabdomyolysis after strenuous physical exercise resulting in myoglobinuria and acute kidney failure have been published, suggesting isotretinoin can damage skeletal muscle tissue. 44 Myalgia and muscle-related complaints were reported in 15 to 50% on isotretinoin, even though increased levels of creatine phosphokinase are mostly benign and transient.…”

“…The procedure was safe except for postoperative dry socket formation in three patients. 4 In this first setting, the main concern is safety.…”