The effects of intravenous cholecystokinin, secretin and pentagastrin on electromyographic activity of the rumen in sheep

Kermani, Rasoul; Rezaiee, Alireza

doi:10.1016/0167-0115(93)90363-d

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…However, whether administration of ghrelin directly affects CH 4 emission remains to be examined in future studies. In contrast to ghrelin, intravenous infusion of cholecystokinin has been shown to depress frequency of reticular contractions and rumen motility3334. Thus, lower CCK plasma concentrations in HM compared to LM cows in week 5 p.p.…”

Section: Discussionmentioning

confidence: 99%

Body fat mobilization in early lactation influences methane production of dairy cows

Bielak

Derno

Tuchscherer

et al. 2016

Sci Rep

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Long-chain fatty acids mobilized during early lactation of dairy cows are increasingly used as energy substrate at the expense of acetate. As the synthesis of acetate in the rumen is closely linked to methane (CH4) production, we hypothesized that decreased acetate utilization would result in lower ruminal acetate levels and thus CH4 production. Twenty heifers were sampled for blood, rumen fluid and milk, and CH4 production was measured in respiration chambers in week −4, +5, +13 and +42 relative to first parturition. Based on plasma non-esterified fatty acid (NEFA) concentration determined in week +5, animals were grouped to the ten highest (HM; NEFA > 580 μmol) and ten lowest (LM; NEFA < 580 μmol) mobilizing cows. Dry matter intake (DMI), milk yield and ruminal short-chain fatty acids did not differ between groups, but CH4/DMI was lower in HM cows in week +5. There was a negative regression between plasma NEFA and plasma acetate, between plasma NEFA and CH4/DMI and between plasma cholecystokinin and CH4/DMI in week +5. Our data show for the first time that fat mobilization of the host in early lactation is inversely related with ruminal CH4 production and that this effect is not attributed to different DMI.

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Section: Discussionmentioning

confidence: 99%

Body fat mobilization in early lactation influences methane production of dairy cows

Bielak

Derno

Tuchscherer

et al. 2016

Sci Rep

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“…and i.v. administration of pentagastrin were demonstrated to inhibit reticulo-ruminal contractions in sheep (Bueno et al, 1984;McLeay and Wong, 1989;Kermani and Rezaiee, 1993). However, i.v.…”

Section: Discussionmentioning

confidence: 89%

Effect of intravenous infusion of proglumide on ruminal motility in conscious sheep (Ovis aries)

Onaga

2007

Vet Res Commun

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The effects of intravenous infusion of proglumide on regular ruminal contractions were examined in conscious sheep using doses that inhibit pancreatic exocrine secretion. After a control period of 20 min, proglumide was infused intravenously for 40 min at a dose of 15, 30 or 60 micromol/kg per min and venous blood was collected. The intravenous infusion of proglumide significantly increased the frequency of ruminal contractions at 15 micromol/kg per min without altering the amplitude, while it significantly decreased the frequency and amplitude of ruminal contractions at 30 and 60 micromol/kg per min in a dose-dependent manner. Proglumide did not increase contractile activity of the omasum, abomasum and duodenum or the plasma concentration of immunoreactive cholecystokinin (CCK). Application of proglumide at 1-30 mmol/L inhibited bethanechol-induced contraction in both longitudinal and circular muscle strips of the dorsal sac of the rumen. These results suggest that proglumide at a low dose acts indirectly on the rumen as a CCK receptor antagonist to increase the frequency of contractions, whereas at higher doses it inhibits cholinergic-induced contraction of the ruminal muscles or acts as an agonist to inhibit contractions in sheep. Hence, proglumide at high doses seems unsuitable for research or therapeutic use as a CCK receptor blockade in sheep.

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Effect of L364 718 on interdigestive pancreatic exocrine secretion and gastroduodenal motility in conscious sheep

Onaga

Hashiguchi

Kato

1997

Regulatory Peptides

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The effects of intravenous cholecystokinin, secretin and pentagastrin on electromyographic activity of the rumen in sheep

Cited by 4 publications

References 12 publications

Body fat mobilization in early lactation influences methane production of dairy cows

Body fat mobilization in early lactation influences methane production of dairy cows

Effect of intravenous infusion of proglumide on ruminal motility in conscious sheep (Ovis aries)

Effect of L364 718 on interdigestive pancreatic exocrine secretion and gastroduodenal motility in conscious sheep

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