The effects of intravenous anaesthetic agents on human neutrophil chemiluminescence

White, I. W. C.; Gelb, Adrian W.; Wexler, H. R.; Cr, Stiller; Keown, P. A.

doi:10.1007/bf03007085

Cited by 49 publications

(22 citation statements)

References 18 publications

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“…The effect of lidocaine on neutrophil ROS production in vitro has been investigated in several studies. In general it has been found that it results in a dose-dependant inhibition, but this occurs at concentrations well in excess of those achieved clinically in plasma [8,24,25]. In only one study was a concentration in the clinical range (1 lg mL )1 ) found to inhibit ROS production measured by chemiluminescence [26].…”

Section: Discussionmentioning

confidence: 89%

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Swanton¹,

Iohom²,

Wang³

et al. 2001

European Journal of Anaesthesiology

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Background and objective Respiratory burst is an essential component of the neutrophil's biocidal function. In vitro, sodium thiopental, iso¯urane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during induction of anaesthesia on neutrophil respiratory burst. Methods Twenty ASA I and II patients, aged 18±60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 lg kg )1 ), thiopental (4±6 mg kg )1 ), iso¯urane (end-tidal concentration 0.5±1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg )1 (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was

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Section: Discussionmentioning

confidence: 89%

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Swanton¹,

Iohom²,

Wang³

et al. 2001

European Journal of Anaesthesiology

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“…Although we did not measure free radicals released from leukocytes, our results demonstrated that lidocaine reduced chemiluminescence in FMLPstimulated isolated neutrophils at clinically relevant plasma concentrations (1±10 lmol L ±1 ). There are also reports showing that lidocaine had no effect on the production of superoxide both by resting and stimulated human neutrophils at therapeutic concentration [17] or neutrophil chemiluminescence [18]. Superoxide formation, assayed by the reduction of ferricytochrome c, was inhibited signi®cantly by 1±10 mmol L ±1 lidocaine in FMLPstimulated neutrophils [3].…”

Section: Discussionmentioning

confidence: 96%

Interaction of lidocaine with reactive oxygen and nitrogen species

Günaydın

Demiryürek

2001

Eur J Anaesthesiol

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“…It has been known for almost a century that anesthetic agents can affect aspects of the immune response [5][6][7], Specific studies have shown that anesthesia can suppress specific components of neutrophil function, including neutrophil chemotaxis [24,25], phagocytosis [26][27][28], bacterial killing capacity [29,30], and superoxide generation [27, 28. 31].…”

Section: Discussionmentioning

confidence: 99%

Suppression of Cytokine-lnduced Neutrophil Accumulation in Rat Mesenteric Venules in vivo by General Anesthesia

Miller¹,

Morita²,

Rangan³

et al. 1996

Int J Microcirc

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Most studies of neutrophil-endothelial interactions in vivo necessarily require the use of general anesthetic agents which are well known to be immunosuppressive. By using whole-mount preparations of the rat mesoappendix, we were able to study tumor necrosis factor alpha (TNF-α) induced neutrophil adhesion to the mesenteric venular endothelium in vivo without necessarily using general anesthesia. TNF-α significantly increased venular-neutrophil accumulation in a dose-dependent manner; accumulation was markedly increased at 1,2, and 4 h, but returned to baseline after 24 h. After these preliminary dose-response and time-course studies, we evaluated the influence of standard clinically effective doses of several commonly used anesthetic agents (thiopental, pentobarbital, ketamine, α-chloralose, methoxyflurane, and halothane) on the extent of neutrophil-venular accumulation induced 2 h after intraperitoneal injection of 0.4 mg/kg TNF-α, compared to unanesthetized rats. All general anesthetics tested, with the exception of methoxyflurane, significantly suppressed this response. In most cases this suppression was striking (from 60 to 85%) such that a statistically significant proinflammatory response was obscured. Although methoxyflurane also tended to suppress this response to TNF-α, it was the only agent that allowed the response to be clearly seen. Because anesthesia markedly suppresses cytokine-induced neutrophil-venular adhesion, this model should provide an important complementary technique to the classical in vivo microcirculatory approaches which do necessarily require general anesthesia.

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The effects of intravenous anaesthetic agents on human neutrophil chemiluminescence

Cited by 49 publications

References 18 publications

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Interaction of lidocaine with reactive oxygen and nitrogen species

Suppression of Cytokine-lnduced Neutrophil Accumulation in Rat Mesenteric Venules in vivo by General Anesthesia

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