The Effects of Intrathecal Tramadol on Spinal Somatosensory-Evoked Potentials and Motor-Evoked Responses in Rats

Jou, I‐Ming; Chu, Koung‐Shing; Chen, Hsing-Hong; Chang, Pei‐Jung; Tsai, Yu‐Chuan

doi:10.1213/01.ane.0000049683.58980.30

Cited by 47 publications

(26 citation statements)

References 20 publications

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“…Both clinical and basic studies indicated that intrathecal tramadol was useful for pain control [26,27], especially for treating neuropathic pain [3,4]. In accordance with previous reports, the present study showed that intrathecal tramadol attenuated SNL-induced neuropathic pain in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 90%

Combination of Tramadol with Minocycline Exerted Synergistic Effects on a Rat Model of Nerve Injury-Induced Neuropathic Pain

et al. 2013

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Neuropathic pain is a refractory clinical problem. Certain drugs, such as tramadol, proved useful for the treatment of neuropathic pain by inhibiting the activity of nociceptive neurons. Moreover, studies indicated that suppression or modulation of glial activation could prevent or reverse neuropathic pain, for example with the microglia inhibitor minocycline. However, few present clinical therapeutics focused on both neuronal and glial participation when treating neuropathic pain. Therefore, the present study hypothesized that combination of tramadol with minocycline as neuronal and glial activation inhibitor may exert some synergistic effects on spinal nerve ligation (SNL)-induced neuropathic pain. Intrathecal tramadol or minocycline relieved SNL-induced mechanical allodynia in a dose-dependent manner. SNL-induced spinal dorsal horn Fos or OX42 expression was downregulated by intrathecal tramadol or minocycline. Combination of tramadol with minocycline exerted powerful and synergistic effects on SNL-induced neuropathic pain also in a dose-dependent manner. Moreover, the drug combination enhanced the suppression effects on SNL-induced spinal dorsal horn Fos and OX42 expression, compared to either drug administered alone. These results indicated that combination of tramadol with minocycline could exert synergistic effects on peripheral nerve injury-induced neuropathic pain; thus, a new strategy for treating neuropathic pain by breaking the interaction between neurons and glia bilaterally was also proposed.

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Section: Discussionsupporting

confidence: 90%

Combination of Tramadol with Minocycline Exerted Synergistic Effects on a Rat Model of Nerve Injury-Induced Neuropathic Pain

et al. 2013

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“…Furthermore, Delilkan et al showed that epidural injection of various doses of tramadol (50 and 100 mg) and 0.25% bupivacaine after surgery resulted in better analgesia and longer periods between epidural injections in the 100-mg tramadol group, although nausea and vomiting were also more common in this group (17). In addition to epidural injection of tramadol in humans, it has central-nervous blockade effects when given intrathecally in animals that are dose dependent (18). In addition to the analgesic effects of tramadol, researchers have also studied the drug's anesthetic influences in vitro and found a local anesthetic effect (19).…”

Section: Discussionmentioning

confidence: 99%

The maternal and neonatal effects of adding tramadol to 2% lidocaine in epidural anesthesia for Cesarean section

et al. 2011

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Background: Opioid analgesics are commonly added to epidural local anesthetics to improve analgesia during surgery. Objectives: The goal of this study was to evaluate the maternal and neonatal effects of adding different doses of tramadol to 2% lidocaine in the epidural anesthesia for cesarean section. Patients and Methods: Ninety pregnant patients who were candidates for cesarean section under epidural anesthesia were randomly categorized into three groups. Group L received 2% lidocaine. In the LT50 and LT100 groups, 50 and 100 mg of tramadol were added to epidural 2% lidocaine. For additional analgesia during surgery, 2% lidocaine through epidural catheter or IV sufentanil were administered. Analgesia after surgery was provided by IV injection of meperidine. Onset and duration of sensory and motor blockades, total drug consumption, neonatal Apgar score, and complications were recorded. Results: In the LT100 group, onset of complete sensory and motor blockade at T6 was less than in the two other groups, but the highest level of sensory blockade and two segment regression and duration of motor blockades between the LT50 and LT100 groups were not significantly different, although they were higher and more prolonged than in the L group. Average lidocaine and sufentanil consumption during surgery between the LT50 and LT100 groups were not significantly different but were lower than in the L group. The incidence of maternal complications and neonatal Apgar scores were not significantly different between the three groups. In the LT50 and LT100 groups, the time until the first request for analgesics after surgery was prolonged, and average meperidine consumption was less than in the L group. Conclusions: The addition of tramadol to epidural 2% lidocaine offers advantages in cesarean section.

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“…Jou et al [14] reported that tramadol affects sensory and motor nerve conduction by a similar mechanism to that of lidocaine, which acts on the voltage-dependent sodium channel leading to axonal blockage. Mert et al [7] proposed that tramadol might have a mechanism different from that of lidocaine for producing conduction blocks; the presence of a large Ca 2?…”

Section: Discussionmentioning

confidence: 99%

Analgesic efficacy of topical tramadol in the control of postoperative pain in children after tonsillectomy

et al. 2010

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The Effects of Intrathecal Tramadol on Spinal Somatosensory-Evoked Potentials and Motor-Evoked Responses in Rats

Cited by 47 publications

References 20 publications

Combination of Tramadol with Minocycline Exerted Synergistic Effects on a Rat Model of Nerve Injury-Induced Neuropathic Pain

Combination of Tramadol with Minocycline Exerted Synergistic Effects on a Rat Model of Nerve Injury-Induced Neuropathic Pain

The maternal and neonatal effects of adding tramadol to 2% lidocaine in epidural anesthesia for Cesarean section

Analgesic efficacy of topical tramadol in the control of postoperative pain in children after tonsillectomy

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