The Effects of Intranasal Challenge with Interleukin-8 (IL-8)

Douglass, Jo A; Gurr, Caroline E.; Shute, Janis K.; Church, Martin K.; Holgate, S. T.

doi:10.1007/978-1-4615-2952-1_73

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Eosinophils and C Hem Okines1

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1996

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“…Although IL-8 has been thought to be a weak chemo attractant for eosinophils, eosinophils isolated from atopic donors or those primed in vitro with GM-CSF, IL-3 or IL-5 show strong migrational responses to IL-8 [134,[142][143][144], In allergic individuals, challenge of nasal epithelium with IL-8 induced tissue eosinophilia [145]. In addition.…”

Section: Eosinophils and C Hem Okinesmentioning

confidence: 99%

Eosinophils in Allergy: Role in Disease, Degranulation, and Cytokines

Martin

Kita

Leiferman

et al. 1996

Int Arch Allergy Immunol

178

106

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For over 100 years, the eosinophil has been associated with allergic diseases. At present, eosinophils appear to be associated pathologically with asthma, atopic dermatitis, allergic rhinitis, eosinophilic gastroenteritis, and certain eye diseases. The effector functions of eosinophils appear to be derived primarily from release of lipid mediators and proteins, including cytokines and granule proteins. Eosinophil degranulation results in the release of several cytotoxic cationic granule proteins. Furthermore, release of cytokines by eosinophils and other cells involved in inflammation amplifies and regulates localized immune responses. Altogether, the eosinophil’s capacity to release and be influenced by a variety of mediators, including the granule proteins and cytokines, implicates this cell in the pathology of inflammation and in the perpetuation of the inflammatory response.

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Section: Eosinophils and C Hem Okinesmentioning

confidence: 99%