The Effects of Intracerebroventricular Cycloheximide on Protein Synthesis and Fever in Rabbits

Cranston, W. I.; Gourine, VN; Townsend, Y

doi:10.1111/j.1476-5381.1981.tb16763.x

Cited by 9 publications

(1 citation statement)

References 5 publications

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“…SUPPRESSION OF FEVER BY IC V ANISOM YCIN The conclusion that protein synthesis in the brain is a necessary step in the production of fever is strengthened by the results presented here, though the evidence is still circumstantial. This inference is supported by the recent demonstration (Cranston, Gourine & Townsend, 1981) that cycloheximide given into the cerebral ventricles also inhibits fever and, unlike systemic cycloheximide, does not affect thermoregulation. If it can be shown that other inhibitors, with structures quite disparate from anisomycin and cycloheximide, also inhibit fever, then an alternative pharmacological explanation for our findings will be less likely.…”

Section: Discussionsupporting

confidence: 70%

Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.

Cranston¹,

Hellon²,

Townsend³

1982

The Journal of Physiology

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SUMMARY1. Anisomycin has been given into the cerebral ventricles of rabbits. The inhibitory action ofa range ofdoses on fever and on [14C]leucine incorporation into hypothalamic protein has been studied.2. Fever was far less sensitive to inhibition by anisomycin than was incorporation of ['4C]leucine. The dose-response curves showed a general similarity in shape, which would be compatible with the hypothesis that protein synthesis may be necessary for the production of fever. 3. A comparison was made of the effects of giving anisomycin into the cerebral ventricles 0, 30 or 60 min after the intraventricular injection of leucocyte pyrogen. Anisomycin inhibited fever to some extent even when given 60 min after leucocyte pyrogen. This suggests that if protein synthesis is involved in fever, it may continue at least into the early phase of rising temperature, but probably not to any significant extent after the plateau has been reached.

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Section: Discussionsupporting

confidence: 70%

Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.

Cranston¹,

Hellon²,

Townsend³

1982

The Journal of Physiology

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Protein Synthesis and Fever

Milton¹,

Sawhney²

1982

Pyretics and Antipyretics

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Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor, anisomycin

et al. 1987

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Fevers induced by intravenous injection of endogenous pyrogen (EP) and intraventricular prostaglandin E2 (PGE2) were significantly prolonged when protein synthesis inhibitor, anisomycin was administrated intraventricularly 30 min before or 1 hr after injection of EP or PGE2. The present results show that protein synthesis in the central nervous system is involved in the development of antipyresis.

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The Effects of Intracerebroventricular Cycloheximide on Protein Synthesis and Fever in Rabbits

Abstract: Cycloheximide(40μg)intracerebroventricularly(i.c.v.) had no effect on thermoregulation against cold, but reduced fever due to an i.e.v. injection of leucocyte pyrogen (LP) by 25%. and reduced incorporation of radioactive leucine into hypothalamic protein by 94%.

Cited by 9 publications

References 5 publications

Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.

Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.

Protein Synthesis and Fever

Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor, anisomycin

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