The Effects of Interval Training on Peripheral Brain Derived Neurotrophic Factor (BDNF) In Young Adults: A Systematic Review and Meta-Analysis

Abstract

The aim of the current meta-analysis was to determine the effects of acute and chronic interval training (IT) on peripheral BDNF concentrations in healthy young adults. A literature search was performed using six databases until February 2020. The TESTEX scale was used to assess the quality of studies. Effect sizes (ES) were computed and two-tailed α values <0 .05 and non-overlapping 95% confidence intervals (95% CI) were considered statistically significant. Heterogeneity, inconsistency (I2), and small-study effects using the Luis Furuya-Kanamori (LFK) index were examined. Fifteen studies (n=277 participants, age =24±3 yr.) were included. The overall effects of IT on circulating BDNF concentrations were moderate and non-significant (ES =0.64, 95%CI = -0.01, 1.30, heterogeneous (p<0.001), highly inconsistent (I2=90%), and with major asymmetry (LFK index =2.85). The acute effect of IT on peripheral BDNF levels was large and significant (ES =1.22, 95%CI =0.08), homogenous (p<0.001), with considerable inconsistency (I2=93%), and major asymmetry (LFK index =3.34). The chronic effect of IT on circulating BDNF was large and significant (ES =0.93, 95%CI =0.40), homogenous (p<0.001), with moderate inconsistency (I2=70%), and minor asymmetry (LFK index =1.21). Acute and chronic IT, elicited a moderate increase in peripheral BDNF concentrations in a healthy young population.

Effect of Intermittent Exercise on Performance in 3D Multiple Objects Tracking in Children, Young and Older Adults—A Pilot Study

“…Most studies examining the effect of exercise on cognitive function focused primarily on continuous forms of exercise such as running or cycling at a constant intensity (low, moderate, and/or high). The number of studies using an intermittent exercise (IE) protocol is limited [33], although acute HIIE protocols tend to increase concentrations of certain extracellular neurochemicals more significantly than low-intensity acute exercise protocols in healthy young adults [31,34,35] and lateand middle-aged older adults [36]. In a prospective randomized controlled trial, Winter et al [37] demonstrated that a HIIE protocol (2 × 3 min sprints) had greater benefits for cognition (vocabulary learning; exercise accelerates learning and improves long-term retention of learned material) than moderate-intensity exercise (40 min running) or a sedentary control condition in healthy male sports students.…”

Usefulness of Detecting Brain-Derived Neurotrophic Factor in Intervertebral Disc Degeneration of the Lumbosacral Spine

“…It plays a role in the development and growth of neurons, memory processes, apoptosis, neurogenesis, and neuroregeneration [ 19 ]. It belongs to the family of neurotrophins (NTs), which are polypeptide growth factors [ 20 ]. Apart from BDNF, these include neurotrophin-3 (NT-3), NT-4, NT-7, and glial cell-derived neurotrophic factor, which are produced in the brain and other tissues [ 21 ].…”