The effects of inspiratory muscle training on exercise capacity, dyspnea and respiratory functions in lung transplantation candidates: a randomized controlled trial

Pehlivan, Esra; Mutluay, Fatma; Balcı, Arif; Kılıç, Lütfiye

doi:10.1177/0269215518777560

Cited by 33 publications

(27 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are studies related to the increase of exercise capacity [22,23], respiratory muscle strength [22] and peripheral muscle strength in lung transplant candidates [24]. Similarly, in our study, exercise capacity, respiratory and peripheral muscle strength were increased by PR.…”

Section: ! "#$%And!b(!e/#2and6!02!6475:!+741+*and!*c-and*and246!#34and-!7%*+2#-supporting

confidence: 83%

The effect of pulmonary rehabilitation on dyspnea and factors related to dyspnea in lung transplantation candidates

Pehlivan

Balcı

Kılıç

2020

The European Research Journal

View full text Add to dashboard Cite

Objectives: Lung transplantation is the last treatment option when conservative treatment is not effective in individuals with terminal stage lung disease. Dyspnea is the primary symptom affecting quality of life in these patients. In our study, the effects of Pulmonary Rehabilitation (PR) on dyspnea and factors related with dyspnea were investigated in lung transplant candidates. Methods: Patients who were in the lung transplant waiting list and completed the 3-month PR program were included in the study. Study result measurements: 6-minute walk test distance (6MWD), lung functions (FEV1, FVC), respiratory muscle strength (MIP, MEP), quadriceps femoris muscle strength as measured by digital dynanometer, hand grip force measured by hand dinanometer (HG) and modified Modified Medical Research Council (mMRC) dyspnea scale. Results: A total of 47 patients were included in the study. After PR, 6MWD (p < 0.0001), MIP (p < 0.0001), MEP (p < 0.0001), HG (p < 0.0001) and mMRC (p < 0.0001) improvements were detected. There was no statistically significant relationship between the decrease in mMRC and the amount of change occurring in other outcome measurements (p > 0.05). Conclusions: According to the results of our study, PR has a positive effect on exercise capacity, peripheral and respiratory muscle strength and dyspnea in lung transplant candidates. But there was no relationship between these positive developments and dyspnea. There is a need for studies investigating the effects of different clinical features on rehabilitation outcomes.

show abstract

Section: ! "#$%And!b(!e/#2and6!02!6475:!+741+*and!*c-and*and246!#34and-!7%*+2#-supporting

confidence: 83%

The effect of pulmonary rehabilitation on dyspnea and factors related to dyspnea in lung transplantation candidates

Pehlivan

Balcı

Kılıç

2020

The European Research Journal

View full text Add to dashboard Cite

show abstract

“…Eight of the 23 included articles were RCTs, 43‐50 five non‐RCTs, 51‐55 and 10 pre‐post studies 18,56‐64 . The majority of the articles included lung (n = 10) 18,43,49,50,55,56,60‐63 (Li et al 18 also included lung‐heart transplant candidates) and heart transplant candidates 45,46,51‐53,57,58 (n = 7). Four articles include liver 47,48,59,64 and two included kidney transplant candidates 44,54 (Gross et al 44 include kidney‐pancreas transplant candidates in addition to kidney patients).…”

Section: Resultsmentioning

confidence: 99%

“…The exercise training programs included in the studies used a variety of exercise interventions, which are described in Table 4. The majority of the programs offered a combination of aerobic training and another type of exercise (n = 17), 18,43,45,46,48‐56,59‐61,63 for instance, upper and/or lower limb strength or inspiratory muscle exercises. Five programs offered only aerobic exercise training 43,49,51,55,61 .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Exercise interventions in solid organ transplant candidates: A systematic review

Souza

Massierer

Raje

et al. 2020

Clinical Transplantation

View full text Add to dashboard Cite

Solid organ transplantation (SOT) saves the lives of patients suffering from end-stage liver, heart, kidney, pancreas, and lung diseases 1,2 and improves disease-related symptoms as well as the quality of life (QoL) in these individuals. 3 Recent statistics show that close to 100 800 solid organ transplants are performed every year worldwide. 4 Many SOT candidates suffer from chronic disease for years before receiving a transplant, and depending on their health condition and which organ is involved, multiple systems may be compromised. 5,6 Studies have shown that SOT candidates experience limitations in exercise capacity secondary to central and peripheral factors 6-9 which may impact their levels of daily physical activity 10-13 and consequently on the psychosocial aspects of their lives. 14 In the general population, physical inactivity reduces normal functioning of major organ systems such as the cardiovascular, cardiopulmonary,

show abstract

“…LTx recipients usually have exercise intolerance and long-term inactivity due to dyspnea, consequently leading to peripheral muscle weakness [24]. Also, immunosuppression therapy could delay recovery of quadriceps strength, making it even harder to recover to the patient's pre-operative physical condition [25,26].…”

Section: Discussionmentioning

confidence: 99%

The Role of Awake Extracorporeal Membrane Oxygenation as Bridging Therapy for Lung Transplantation: A Retrospective Cohort Study

Kim¹,

Kim²,

Leem³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background As lung transplantation (LTx) becomes a standard treatment for end-stage lung disease, bridging to LTx with extracorporeal membrane oxygenation (ECMO) is increasing during waiting time, for either rescue treatment or improving ability to rehabilitation before transplant. This study investigated post-operative outcomes in patients bridging to lung transplantation with ECMO, especially those receiving awake ECMO. Methods In this single-center study, we retrospectively reviewed 241 consecutive LTx patients between October 2012 and March 2019. Among them, 65 patients received ECMO support while waiting for LTx; these patients were analyzed according to their awakeness. Multivaribale logistic regression and Cox proportional hazard models were used to analyze variables associated awake strategy and mortality. Results Thirty-three patients (50.7%) were awake during bridging ECMO, and 32 patients (49.2%) were in sedative status. The median age of awake ECMO patients was 59.0 (IQR 54.0-63.0) years, and 63.1% of population was male. There were no significant differences between awake and non-awake ECMO patients with respect to age, comorbidities, APACHE II score, ECMO duration and ECMO blood flow. Awake group have better post-operative outcome in terms of statically shorter post-operative intensive care unit (ICU) length of stay (LOS) (awake vs. non-awake, 6 [4-9.5] vs. 16 [6-22], p = 0.004) and longer ventilator free days (VFDs) (awake vs. non-awake, 24 [11.0-25.0] vs. 0 [0.0-14.5], p = 0.001). Furthermore, the awake ECMO group had a significantly lower six-month mortality rate compared to the non-awake group (18.2% vs. 40.6%, p = 0.045). It was independent predictive factor for ability to gait after LTx ([OR] 4.128, 95% CI 1.094-15.572, p = 0.036). Conclusions Awake ECMO therapy could be useful for high-risk patients waiting for LTx, and might help shorten ICU LOS and improve survival benefit after LTx. Furthermore, awake ECMO was independent predictive factor for postoperative gaiting.

show abstract

The effects of inspiratory muscle training on exercise capacity, dyspnea and respiratory functions in lung transplantation candidates: a randomized controlled trial

Abstract: A greater increase in exercise capacity was observed in the PR + IMT group. Our study showed that inspiratory muscle training improved exercise capacity even further and increased the benefits provided by pulmonary rehabilitation.

Cited by 33 publications

References 50 publications

The effect of pulmonary rehabilitation on dyspnea and factors related to dyspnea in lung transplantation candidates

The effect of pulmonary rehabilitation on dyspnea and factors related to dyspnea in lung transplantation candidates

Exercise interventions in solid organ transplant candidates: A systematic review

The Role of Awake Extracorporeal Membrane Oxygenation as Bridging Therapy for Lung Transplantation: A Retrospective Cohort Study

Contact Info

Product

Resources

About