The effects of induced apneic episodes on cerebral cortical oxygenation in newborn piglets

Apnea Is Associated with Neurodevelopmental Impairment in Very Low Birth Weight Infants

“…Such hypoxia/reoxygenation injury could well generate oxygen free radicals and lead to cellular injury in the developing cortex. 11 Thus, there is at least the potential for apneic spells to cause cerebral injury.…”

Impaired Early Neurologic Outcome in Newborn Piglets Reoxygenated with 100% Oxygen Compared with Room Air after Pneumothorax-Induced Asphyxia

“…Increasing FiO 2 levels facilitates posthypoxic cerebral cortical hyperoxia (47) and results not only in cerebral, but also in systemic, oxidative damage (48). Although the blood oxidative stress indicator levels in our study did not reveal any significant liberation of potentially highly damaging mediators, on the basis of previously published observations (12,49) (as there were no other significant differences between the two asphyxiated groups apart from the arterial PO 2 values) we presume the deleterious effects of hyperoxia on the neuronal cell membranes were caused either by increasing cerebral dopamine concentration (50,51) or by other lipid peroxidation products (52-55) not measured here.…”

A new technique for the mapping of oxygen tension on the brain surface

“…However, the insertion of microelectrodes into the brain per se causes cortical injury, and hence could lead to erroneous PO 2 measurements. The utilization of the "quenching lifetime method" for mapping tissue PO 2 [5,7,25], although apparently non-invasive, is not always desirable for clinical purposes, because of the possible side effects of the fluorescent chemical employed in the human body. The present study was undertaken to address this issue by applying our oxygen-sensitive fluorescence membrane technique [9] to the measurement of the PO 2 distribution on the rat brain surface.…”