The effects of indoor particle exposure on blood pressure and heart rate among young adults: An air filtration-based intervention study

Lin, Lian‐Yu; Chen, Hua Wei; Su, Te Li; Hong, Gui Bing; Huang, Li; Chuang, Kai Jen

doi:10.1016/j.atmosenv.2011.05.014

Cited by 42 publications

(21 citation statements)

References 21 publications

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“…In contrast, Allen et al saw reductions in hsCRP and IL-6 in a crossover trial for wood smoke, though the exposure was PM 2.5 rather than urban UFP [29]. Lin et al found that for 60 healthy students, indoor PM 2.5 was associated more strongly with blood pressure and heart rate when there was no air filtration [30]. Chen et al reported that air filtration was significantly associated with decreases in monocyte chemoattractant protein-1, interleukin-1b, myeloperoxidase, and soluble CD40 ligand in 35 health college students.…”

Section: Discussionmentioning

confidence: 99%

Lessons from in-home air filtration intervention trials to reduce urban ultrafine particle number concentrations

Brugge

Simon

Hudda

et al. 2017

Building and Environment

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Background Exposure to airborne ultrafine particle (UFP; <100 nm in aerodynamic diameter) is an emerging public health problem. Nevertheless, the benefit of using high efficiency particulate arrestance (HEPA) filtration to reduce UFP concentrations in homes is not yet clear. Methods We conducted a randomized crossover study of HEPA filtration without a washout period in 23 homes of low-income Puerto Ricans in Boston and Chelsea, MA (USA). Most participants were female, older adults who were overweight or obese. Particle number concentrations (PNC, a proxy for UFP) were measured indoors and outdoors at each home continuously for six weeks. Homes received both HEPA filtration and sham filtration for three weeks each in random order. Results Median PNC under HEPA filtration was 50–85% lower compared to sham filtration in most homes, but we found no benefit in terms of reduced inflammation; associations between hsCRP, IL-6, or TNFRII in blood samples and indoor PNC were inverse and not statistically significant. Conclusions Limitations to our study design likely contributed to our findings. Limitations included carry-over effects, a population that may have been relatively unresponsive to UFP, reduction in PNC even during sham filtration that limited differences between HEPA and sham filtration, window opening by participants, and lack of fine-grained (room-specific) participant time-activity information. Our approach was similar to other recent HEPA intervention studies of particulate matter exposure and cardiovascular risk, suggesting that there is a need for better study designs.

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Section: Discussionmentioning

confidence: 99%

Lessons from in-home air filtration intervention trials to reduce urban ultrafine particle number concentrations

Brugge

Simon

Hudda

et al. 2017

Building and Environment

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“…Henderson et al also reported a PM 2.5 decrease of 63–88 % in homes during wildfires and prescribed burns [27]. More importantly, several recent studies have shown significant cardiovascular health benefits can be realized through the reduction of exposure to PM 2.5 while indoors by HEPA filtration [29,30•,31]. Weichenthal et al reported that electrostatic filtration use was associated with small decreases in systolic BP and diastolic BP [32].…”

Section: Interventions To Reduce Air Pollution Exposures At a Personamentioning

confidence: 99%

Understanding Air Pollution and Cardiovascular Diseases: Is It Preventable?

Morishita

Thompson

Brook

2015

Curr Cardiovasc Risk Rep

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Fine particulate matter (<2.5 µm, PM2.5) air pollution is a leading risk factor for morbidity and mortality worldwide. The largest portion of adverse health effects is from cardiovascular diseases. In North America, PM2.5 concentrations have shown a steady decline over the past several decades; however, the opposite trend has occurred throughout much of the developing world whereby daily concentrations commonly reach extraordinarily high levels. While air quality regulations can reduce air pollution at a societal level, what individuals can do to reduce their personal exposures remains an active field of investigation. Here, we review the emerging evidence that several interventions (e.g., air filters) and/or behavioral changes can lower PM pollution exposure and as such, may be capable of mitigating the ensuing adverse cardiovascular health consequences. Air pollution remains a worldwide epidemic and a multi-tiered prevention strategy is required in order to optimally protect global public health.

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“…High-efficiency particle air filters are increasingly being used in central residential HVAC systems to reduce indoor concentrations of particulate matter of both indoor and outdoor origins (Burroughs and Kinzer 1998;Fugler et al 2000;Brauner et al 2007;MacIntosh et al 2008MacIntosh et al , 2010Stephens et al 2010aStephens et al , 2010bLin et al 2011;Brown et al 2014). Several previous investigations have explored the impacts of HVAC filters on particle concentrations in residences through a combination of measurements and models (Riley et al 2002;Howard-Reed et al 2003;Wallace et al 2004;MacIntosh et al 2010;Brown et al 2014).…”

Section: Introductionmentioning

confidence: 96%

Modeling the impact of residential HVAC filtration on indoor particles of outdoor origin (RP-1691)

Azimi

Zhao

Stephens

2016

Science and Technology for the Built Environment

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Much of human exposure to airborne particles of outdoor origin, including fine particles smaller than 2.5 μm (PM 2.5 ) and ultrafine particles smaller than 0.1 μm (UFPs), occurs in residences. High-efficiency central HVAC filters are increasingly being used in residences, but questions remain about their effectiveness in reducing indoor PM 2.5 and UFPs of outdoor origin in homes operating under realistic conditions (e.g., with HVAC systems operating only to meet heating or cooling demands). Here dynamic building energy and indoor air mass balance modeling are combined to estimate the impacts of 11 HVAC filters (minimum efficiency reporting value [MERV] 5 through high-efficiency particulate air [HEPA]) on indoor concentrations of PM 2.5 and UFPs of outdoor origin in multiple vintages of prototypical single-family residences relying on either infiltration or mechanical ventilation systems in 22 U.S. cities. Results demonstrate that higher-efficiency HVAC filters can meaningfully reduce indoor proportions of outdoor PM 2.5 and UFPs inside residences, but home vintage, climate zone, and ventilation strategy strongly influence the outcomes due to widely varying air exchange rates, HVAC system runtimes, and sources of ventilation air. Higher efficiency filters had a greater impact in older, leakier homes relying on infiltration alone and in new homes relying on supply-only mechanical ventilation systems designed to meet ASHRAE Standard 62.2.

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The effects of indoor particle exposure on blood pressure and heart rate among young adults: An air filtration-based intervention study

Cited by 42 publications

References 21 publications

Lessons from in-home air filtration intervention trials to reduce urban ultrafine particle number concentrations

Lessons from in-home air filtration intervention trials to reduce urban ultrafine particle number concentrations

Understanding Air Pollution and Cardiovascular Diseases: Is It Preventable?

Modeling the impact of residential HVAC filtration on indoor particles of outdoor origin (RP-1691)

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