The effects of indoor and outdoor dust exposure on the growth, sensitivity to oxidative-stress, and biofilm production of three opportunistic bacterial pathogens

Suraju, Mohammed O.; Lalinde-Barnes, Sloan; Sanamvenkata, Sachindra; Esmaeili, Mahsa; Shishodia, Shishir; Rosenzweig, Jason A.

doi:10.1016/j.scitotenv.2015.08.063

Cited by 33 publications

(18 citation statements)

References 48 publications

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“…To investigate the impact of BC on bacterial biofilms, S. pneumoniae strains D39 and PR201, and S. aureus strains SH1000, Newman, and USA300, were exposed to 30-100 mg/ml BC during biofilm formation. BC concentrations were based on previous research into the effects of BC on the host, as well as research into the effects of other pollutants on bacteria (Tellabati et al, 2010;Vesterdal et al, 2012;Suraju et al, 2015). These concentrations do not represent actual atmospheric BC concentrations in the UK which range from 1 to 7 mg/m 3 (Butterfield et al, 2015) because atmospheric BC is inhaled over time, with constant deposition within the respiratory tract, therefore high concentration suspensions are typically used to model this long-term exposure.…”

Section: Resultsmentioning

confidence: 99%

Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation

Hussey

Purves

Allcock

et al. 2017

Environmental Microbiology

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SummaryAir pollution is the world's largest single environmental health risk (WHO). Particulate matter such as black carbon is one of the main components of air pollution. The effects of particulate matter on human health are well established however the effects on bacteria, organisms central to ecosystems in humans and in the natural environment, are poorly understood. We report here for the first time that black carbon drastically changes the development of bacterial biofilms, key aspects of bacterial colonisation and survival. Our data show that exposure to black carbon induces structural, compositional and functional changes in the biofilms of both S. pneumoniae and S. aureus. Importantly, the tolerance of the biofilms to multiple antibiotics and proteolytic degradation is significantly affected. Additionally, our results show that black carbon impacts bacterial colonisation in vivo. In a mouse nasopharyngeal colonisation model, black carbon caused S. pneumoniae to spread from the nasopharynx to the lungs, which is essential for subsequent infection. Therefore our study highlights that air pollution has a significant effect on bacteria that has been largely overlooked. Consequently these findings have important implications concerning the impact of air pollution on human health and bacterial ecosystems worldwide.

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Section: Resultsmentioning

confidence: 99%

Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation

Hussey

Purves

Allcock

et al. 2017

Environmental Microbiology

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“…This was commensurate with increased biofilm formation and sensitivity to oxidative stress following hydrogen peroxide challenge. 65 Consequently, the detrimental impact of particulate pollutants on human health is not only due to direct effects on the host but also may involve the effect on bacterial behavior in the host.…”

Section: Infectious Particlesmentioning

confidence: 99%

Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD)

Rouadi¹,

Idriss²,

Naclerio³

et al. 2020

World Allergy Organization Journal

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Air pollution causes significant morbidity and mortality in patients with inflammatory airway diseases (IAD) such as allergic rhinitis (AR), chronic rhinosinusitis (CRS), asthma, and chronic obstructive pulmonary disease (COPD). Oxidative stress in patients with IAD can induce eosinophilic inflammation in the airways, augment atopic allergic sensitization, and increase susceptibility to infection. We reviewed emerging data depicting the involvement of oxidative stress in IAD patients. We evaluated biomarkers, outcome measures and immunopathological alterations across the airway mucosal barrier following exposure, particularly when accentuated by an infectious insult.

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“…Notwithstanding the recognized dangers for human health of Aspergillus and other fungi, our knowledge showed an absence of contamination of airways [3] and no studies are available that prove the possible contamination of airways of healthy subjects with outdoor fungal spores. Furthermore, there is still limited evidence of possible physiological impact of fungal contamination on the respiratory system [9].…”

Section: Introductionmentioning

confidence: 99%

A survey of fungal microbiota in airways of healthy volunteer subjects from Puglia (Apulia), Italy

et al. 2019

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BackgroundThe human respiratory tract represents the major portal of entry for numerous microorganisms, primarily those occurring as airborne particles such as viral and bacterial entities, or fungal spores. Microorganism characteristics coupled with the local host immune response will determine whether they will be cleared or adhere and colonize the airways leading to acute or chronic pulmonary disease. Like bacteria, fungi can cause severe lung diseases, but their infection rates are much lower. The lung microbiota is commonly sampled using relatively invasive bronchoscopic procedures. Exhaled breath condensate (EBC) collection offers a potentially less invasive alternative for lung microbiota sampling. This study tries to determine the composition of fungal communities in a cohort of healthy adult volunteer subjects from Puglia (Apulia), Italy.MethodsFungi diversity in 27 EBC samples collected from Italian adult volunteers was investigated using conventional microbiological culturing and DNA sequencing approach.ResultsTen tested subjects (37,03%) turned out to present fungi in the EBC. We observed complex fungal communities, in which more than 10% of the isolated species are represented by Aspergillus sydowii (14,8%) and Cladosporium spp (11,11%). Three subjects that showed fungal presence in EBC have been diagnosed with a respiratory disease.ConclusionsWe present a survey of an important scientific field in its early stages that is fungal contamination of airways of healthy subjects in a small geographic area. Furthermore, we interpreted our results to highlight the potential role of fungi in the context of respiratory diseases.

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The effects of indoor and outdoor dust exposure on the growth, sensitivity to oxidative-stress, and biofilm production of three opportunistic bacterial pathogens

Cited by 33 publications

References 48 publications

Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation

Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation

Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD)

A survey of fungal microbiota in airways of healthy volunteer subjects from Puglia (Apulia), Italy

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