The Effects of Inbreeding, Cross-Breeding, and Selection upon the Fertility and Variability of Drosophila

Castle, W. E.; Carpenter, F. W.; Clark, Andrew Hill; Mast, S. O.; Barrows, W. M.

doi:10.2307/20022155

Cited by 42 publications

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“…The first experimental publication on Drosophila amelophila (as D. melanogaster was also known back then) was from Castle's lab (Castle et al, 1906). In a series of studies begun in 1901, Castle and his coworkers tested Drosophila for its tolerance of inbreeding.…”

Section: Introductionmentioning

confidence: 99%

The Varieties of Selectional Experience in Behavioral Genetics

Greenspan¹

2003

Journal of Neurogenetics

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Section: Introductionmentioning

confidence: 99%

The Varieties of Selectional Experience in Behavioral Genetics

Greenspan¹

2003

Journal of Neurogenetics

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“…I was, of course, familiar with the important paper of Castle, Carpenter, Clarke, Mast and Barrows and used it in my lecture on experimental zoology (Castle et al 1906). …”

Section: Caltechmentioning

confidence: 99%

Weaving a Tapestry from Threads Spun by Geneticists: The Series Perspectives on Genetics, 1987–2008

Dove

2016

Genetics

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The Perspectives column was initiated in 1987 when Jan Drake, Editor-in-Chief of GENETICS, invited Jim Crow and William Dove to serve as coeditors of "Anecdotal, Historical, and Critical Commentaries." As the series evolved over 21 years, under the guidance of Crow and Dove, the input of stories told by geneticists from many countries created a panorama of 20th-century genetics. Three recurrent themes are visible: how geneticists have created the science (as solitary investigators, in pairs, or in cooperative groups); how geneticists work hard, but find ways to have fun; and how public and private institutions have sustained the science of genetics, particularly in the United States. This article ends by considering how the Perspectives series and other communication formats can carry forward the core science of genetics from the 20th into the 21st century.

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“…Castle [10] reported the effects of inbreeding on fertility and concluded that Drosophila can be maintained by constant inbreeding (brother with sister) with no effects on the variability of the number of teeth on the sex-comb and productiveness of offspring. It is convenient for us to maintain stocks by inbreeding because there is no need to select fl ies carrying phenotype(s) specifi c to the stock every generation.…”

Section: Stock Maintenancementioning

confidence: 99%

Drosophila Genetic Resource and Stock Center; The National BioResource Project

Yamamoto

2010

Exp. Anim.

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Abstract:The fruit fly, Drosophila melanogaster, is not categorized as a laboratory animal, but it is recognised as one of the most important model organisms for basic biology, life science, and biomedical research. This tiny fly continues to occupy a core place in genetics and genomic approaches to studies of biology and medicine. The basic principles of genetics, including the variations of phenotypes, mutations, genetic linkage, meiotic chromosome segregation, chromosome aberrations, recombination, and precise mapping of genes by genetic as well as cytological means, were all derived from studies of Drosophila. Recombinant DNA technology was developed in the 1970s and Drosophila DNA was the first among multicellular organisms to be cloned. It provided a detailed characterization of genes in combination of classical cytogenetic data. Drosophila thus became the pioneering model organism for various fields of life science research into multicellular organisms. Here, I briefly describe the history of Drosophila research and provide a few examples of the application of the abundant genetic resources of Drosophila to basic biology and medical investigations. A Japanese national project, the National BioResource Project (NBRP) for collection, maintainance, and provision of Drosophila resources, that is well known and admired by researchers in other countries as an important project, is also briefly described.

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The Effects of Inbreeding, Cross-Breeding, and Selection upon the Fertility and Variability of Drosophila

Cited by 42 publications

References 0 publications

The Varieties of Selectional Experience in Behavioral Genetics

The Varieties of Selectional Experience in Behavioral Genetics

Weaving a Tapestry from Threads Spun by Geneticists: The Series Perspectives on Genetics, 1987–2008

Drosophila Genetic Resource and Stock Center; The National BioResource Project

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