The effects of inactivation methods of <i>Yersinia ruckeri</i> on the efficacy of single dip vaccination in Atlantic salmon <i>(Salmo salar)</i>

Nguyen, Diem Thu; Crosbie, Philip; Nowak, Barbara; Bridle, Andrew R.

doi:10.1111/jfd.12803

Cited by 9 publications

(6 citation statements)

References 28 publications

(31 reference statements)

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“…salmonicida Salmonids Inactivated Immersion, IP Inactivated Aeromonas salmonicida spp. - Thornton et al ( 1991 ) Columnaris disease Flavobacterium columnaris Freshwater finfish species, Nile tilapia, bass, bream, salmon, turbot Attenuated Immersion Attenuated Flavobacterium columnare Experimental Shoemaker et al ( 2011 ); Mohammed et al ( 2013 ) Enteric redmouth disease (ERM) Yersinia ruckeri Salmonids rainbow trout Inactivated Immersion oral Inactivated Yersinia ruckeri Experimental Costa et al ( 2011 ); Villumsen et al ( 2014 ); Nguyen et al ( 2018 ) Ma et al ( 2019 ); Bøgwald and Dalmo ( 2019 ); Miccoli et al ( 2021 ) …”

Section: Current Status Of Fish Vaccines and Its Applications-mentioning

confidence: 99%

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

Mondal

Thomas

2022

Aquacult Int

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Globally, aquaculture has faced serious economic problems due to bacterial, viral, and various other infectious diseases of different origins. Even though such diseases are being detected and simultaneously treated with several therapeutic and prophylactic methods, the broad-spectrum activity of vaccines plays a vital role as a preventive measure in aquaculture. However, treatments like use of antibiotics and probiotics seem to be less effective when new mutant strains develop and disease causing pathogens become resistant to commonly used antibiotics. Therefore, vaccines developed by using recent advanced molecular techniques can be considered as an effective way of treating disease causing pathogens in aquatic organisms. The present review emphasizes on the current advances in technology and future outlook with reference to different types of vaccines used in the aquaculture industries. Beginning with traditional killed/inactivated and live attenuated vaccines, this work culminates in the review of modern new generation ones including recombinant, synthetic peptides, mucosal and DNA, subunit, nanoparticle-based and plant-based edible vaccines, reverse vaccinology, and monovalent and polyvalent vaccines.

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Section: Current Status Of Fish Vaccines and Its Applications-mentioning

confidence: 99%

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

Mondal

Thomas

2022

Aquacult Int

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“…An opposite scenario was reported by Nguyen et al [53], who observed higher survival rates in fish vaccinated against Yersinia ruckeri without finding any significant response antibody-wise. The authors compared the efficacy of vaccines produced by three different inactivation methods, namely, 0.3% formalin, 50% ammonium sulfate followed by 60 °C for 2 h, and cell lysis by a pH shock (from 10 to 7.4) followed by a 0.3% formalin treatment.…”

Section: Bacterial Diseasesmentioning

confidence: 65%

“…This field has progressed significantly in the last decades: many vaccine types were developed (i.e., attenuated, inactivated, subunit, recombinant, and DNA) [17], and all proved at least partially effective against some pathogens. Many of the discussed studies produced encouraging results, achieving very high survival rates and specific antibody titers in challenge trials, even though it must be remembered that the correlates between antibody quantity/functional characteristics and induced immunity may be poor [106], as found in several studies [20,24,45,49,52,53,58]: a vaccine efficacy should never be solely investigated by means of serological assays.…”

Section: Discussionmentioning

confidence: 99%

State-of-the-Art Vaccine Research for Aquaculture Use: The Case of Three Economically Relevant Fish Species

et al. 2021

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In the last three decades, the aquaculture sector has experienced a 527% growth, producing 82 million tons for a first sale value estimated at 250 billion USD. Infectious diseases caused by bacteria, viruses, or parasites are the major causes of mortality and economic losses in commercial aquaculture. Some pathologies, especially those of bacterial origin, can be treated with commercially available drugs, while others are poorly managed. In fact, despite having been recognized as a useful preventive measure, no effective vaccination against many economically relevant diseases exist yet, such as for viral and parasitic infections. The objective of the present review is to provide the reader with an updated perspective on the most significant and innovative vaccine research on three key aquaculture commodities. European sea bass (Dicentrarchus labrax), Nile tilapia (Oreochromis niloticus), and Atlantic salmon (Salmo salar) were chosen because of their economic relevance, geographical distinctiveness, and representativeness of different culture systems. Scientific papers about vaccines against bacterial, viral, and parasitic diseases will be objectively presented; their results critically discussed and compared; and suggestions for future directions given.

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“…Atlantic salmon is the primary salmon species in farming worldwide [ 4 ], and many vaccine formulations have been proposed to control infectious diseases that affect it. For instance, vaccines have been developed for Vibrio anguillarum [ 5 ], Yersinia ruckeri [ 6 ], salmonid alphavirus (SAV) [ 7 ], Moritella viscosa [ 8 ], infectious pancreatic necrosis virus (IPNV), infectious salmon anemia virus (ISAV) [ 9 ], Lepeoptheirus salmonis [ 10 , 11 ], and C. rogercresseyi [ 12 , 13 , 14 ]. Most candidate vaccines are developed with an attenuated or killed microorganism component or a particular surface protein or toxin.…”

Section: Introductionmentioning

confidence: 99%

Comparative Transcriptomics in Atlantic Salmon Head Kidney and SHK-1 Cell Line Exposed to the Sea Louse Cr-Cathepsin

Leal

Valenzuela-Muñoz

Casuso

et al. 2023

Genes

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The development of vaccines against sea lice in salmon farming is complex, expensive, and takes several years for commercial availability. Recently, transcriptome studies in sea louse have provided valuable information for identifying relevant molecules with potential use for fish vaccines. However, the bottleneck is the in vivo testing of recombinant protein candidates, the dosage, and the polyvalent formulation strategies. This study explored a cell-based approach to prospect antigens as candidate vaccines against sea lice by comparison with immunized fish. Herein, SHK-1 cells and Atlantic salmon head kidney tissue were exposed to the antigen cathepsin identified from the sea louse Caligus rogercresseyi. The cathepsin protein was cloned and recombinantly expressed in Escherichia coli, and then SHK-1 cell lines were stimulated with 100 ng/mL cathepsin recombinant for 24 h. In addition, Atlantic salmons were vaccinated with 30 ug/mL recombinant protein, and head kidney samples were then collected 30 days post-immunization. SHK-1 cells and salmon head kidney exposed to cathepsin were analyzed by Illumina RNA sequencing. The statistical comparisons showed differences in the transcriptomic profiles between SHK-1 cells and the salmon head kidney. However, 24.15% of the differentially expressed genes were shared. Moreover, putative gene regulation through lncRNAs revealed tissue-specific transcription patterns. The top 50 up and downregulated lncRNAs were highly correlated with genes involved in immune response, iron homeostasis, pro-inflammatory cytokines, and apoptosis. Also, highly enriched pathways related to the immune system and signal transduction were shared between both tissues. These findings highlight a novel approach to evaluating candidate antigens for sea lice vaccine development, improving the antigens screening in the SHK-1 cell line model.

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The effects of inactivation methods of Yersinia ruckeri on the efficacy of single dip vaccination in Atlantic salmon (Salmo salar)

Cited by 9 publications

References 28 publications

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

State-of-the-Art Vaccine Research for Aquaculture Use: The Case of Three Economically Relevant Fish Species

Comparative Transcriptomics in Atlantic Salmon Head Kidney and SHK-1 Cell Line Exposed to the Sea Louse Cr-Cathepsin

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