The effects of in vitro cotitine on nasal ciliary beat frequency

Agius, Andee; Wake, M.; Pahor, A. L.; Smallman, A.

doi:10.1111/j.1365-2273.1995.tb00083.x

Cited by 12 publications

(7 citation statements)

References 31 publications

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“…39 Various chemicals in cigarette smoke, including acrolein, formaldehyde, carbon monoxide, nicotine, cotinine, acetaldehyde, phenol, and potassium cyanide, have been identified as having high toxicity to respiratory cilia. 14,40,41 Additionally, tobacco smoke exposure has been shown to increase several proinflammatory cytokines such as TNF-α 42,43 contributing to both epithelial and/or cilia shedding. However, our data suggest that compounds found within both the particulate and the gas fractions of tobacco smoke inhibit ciliogenesis.…”

Section: Discussionmentioning

confidence: 99%

Cigarette Smoke Exposure Impairs Respiratory Epithelial Ciliogenesis

Tamashiro

Xiong

Anselmo‐Lima

et al. 2009

Am J Rhinol�Allergy

118

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Section: Discussionmentioning

confidence: 99%

Cigarette Smoke Exposure Impairs Respiratory Epithelial Ciliogenesis

Tamashiro

Xiong

Anselmo‐Lima

et al. 2009

Am J Rhinol�Allergy

118

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“…Tobacco smoke exposure is considered an important negative prognostic factor for chronic rhinosinusitis (CRS), and smoking has been demonstrated to increase the risk for CRS [ 9 ]. Tobacco smoke is composed of a complex mixture of over 5000 substances [ 274 ] and various chemicals in tobacco smoke have been identified as having high toxicity to respiratory cilia [ 275 – 277 ]. Additionally, tobacco smoke exposure has been shown to increase pro-inflammatory cytokines such as TNF-α contributing to harm respiratory mucosa [ 278 , 279 ].…”

Section: Co-morbidities and Contributing Factors – Smoking Brochiectmentioning

confidence: 99%

ICON: chronic rhinosinusitis

Bachert¹,

Pawankar

Zhang

et al. 2014

World Allergy Organization Journal

185

175

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Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-economic impact. Moreover, the complexity of this disease due to its heterogeneous nature based on the underlying pathophysiology - leading to different disease variants - further complicates our understanding and directions for the most appropriate targeted treatment strategies. Several International/national guidelines/position papers and/or consensus documents are available that present the current knowledge and treatment strategies for CRS. Yet there are many challenges to the management of CRS especially in the case of the more severe and refractory forms of disease. Therefore, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), a collaboration between EAACI, AAAAI, ACAAI, and WAO, has decided to propose an International Consensus (ICON) on Chronic Rhinosinusitis. The purpose of this ICON on CRS is to highlight the key common messages from the existing guidelines, the differences in recommendations as well as the gaps in our current knowledge of CRS, thus providing a concise reference. In this document we discuss the definition of the disease, its relevance, pharmacoeconomics, pathophysiology, phenotypes and endotypes, genetics and risk factors, natural history and co-morbidities as well as clinical manifestations and treatment options in both adults and children comprising pharmacotherapy, surgical interventions and more recent biological approaches. Finally, we have also highlighted the unmet needs that wait to be addressed through future research.

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“…Airway epithelial cell cilia are motile cilia, but these cilia have sensory functions and can respond to mechanical and chemical stimuli [56,57,58,59]. In bronchial explants of human respiratory mucosa, ciliary activity was significantly influenced by chemical (pH) and physical properties (viscosity) of the liquid medium in which the cilia beat [60].…”

Section: Airway Epithelium: a Specialized Physical Secretory Andmentioning

confidence: 99%

Airway Epithelial Cell Cilia and Obstructive Lung Disease

Yaghi

Dolovich

2016

Cells

118

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Airway epithelium is the first line of defense against exposure of the airway and lung to various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an important part of the mucociliary transport apparatus. To be effective in transporting secretions out of the lung, the mucociliary transport apparatus must exhibit a cohesive beating of all ciliated epithelial cells that line the upper and lower respiratory tract. Cilia function can be modulated by exposures to endogenous and exogenous factors and by the viscosity of the mucus lining the epithelium. Cilia function is impaired in lung diseases such as COPD and asthma, and pharmacologic agents can modulate cilia function and mucus viscosity. Cilia beating is reduced in COPD, however, more research is needed to determine the structural-functional regulation of ciliary beating via all signaling pathways and how this might relate to the initiation or progression of obstructive lung diseases. Additionally, genotypes and how these can influence phenotypes and epithelial cell cilia function and structure should be taken into consideration in future investigations.

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The effects of in vitro cotitine on nasal ciliary beat frequency

Cited by 12 publications

References 31 publications

Cigarette Smoke Exposure Impairs Respiratory Epithelial Ciliogenesis

Cigarette Smoke Exposure Impairs Respiratory Epithelial Ciliogenesis

ICON: chronic rhinosinusitis

Airway Epithelial Cell Cilia and Obstructive Lung Disease

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