The effects of implanting anuran cancer into non‐regenerating and regenerating larval urodele limbs

Ruben, Laurens N.

doi:10.1002/jez.1401280104

Cited by 36 publications

(6 citation statements)

References 19 publications

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“…Similar experiments with the larval newts Amblystoma maculatum and A. IN opacum by Ruben (1955) showed that frog renal carcinoma implants were not POIKILOTHERMS affected by limb regeneration. However, details concerning the biological behavior and ultimate fate of the tumor implants were not given; a comparison of such data in normal newts with those undergoing limb regeneration would be of interest.…”

Section: Regeneration and Neoplastic Growth In Urodelessupporting

confidence: 52%

Neoplasia in Poikilotherms

Scarpelli

1975

Biology of Tumors: Surfaces, Immunology, and Comparative Pathology

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Section: Regeneration and Neoplastic Growth In Urodelessupporting

confidence: 52%

Neoplasia in Poikilotherms

Scarpelli

1975

Biology of Tumors: Surfaces, Immunology, and Comparative Pathology

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“…Ruben (1960) emphasized the immunological aspects in the degree of response to a deflected nerve (see also, Ruben and Frothingham, 1958). Ruben (1955) found that frog kidney adenocarcinoma transplants into newt limbs were less effective than normal frog kidney in eliciting the accessory growth response. Trampusch and Harrebombe (1969) created an artificial wound-epithelium to promote degradation of the implanted tissue under flank skin of juvenile axolotls.…”

mentioning

confidence: 99%

Accessory limb production by nerve‐induced cell proliferation

Egar

1988

Anat. Rec.

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The deviation of large limb nerves to a more proximal skin wound yielded a high proportion of accessory limb responses in different age groups of Ambystoma mexicanum (axolotls). In some instances the deviated nerve was positioned on skin previously grafted from an animal of different age and pigmentation from that of the host. Grafts were found not to be a necessary prerequisite for accessory limb induction, but the presence of wound epithelium was required. The rule of distal morphogenesis was expressed in reference to the level at which the nerve was cut, not in reference to the wound site where the accessory actually developed. The upper arm proved to be a more favorable site for accessory limb production than the flank or the leg under the conditions of the present experiments, in which little or no damage was done to the underlying muscles. The orientation of the accessory limb was extremely varied despite the uniformity of the surgical procedure.

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“…R uben [15] studied this system more extensively and reported that implants of Lucké frog renal adenocarcinomas induced a high percentage of supernumerary limbs in larval urodeles. He also demonstrated that implants of normal adult frog kidney induced supernumerary limbs in adult newts in close to 100% of cases [16].…”

Section: Introductionmentioning

confidence: 99%

The Distribution of Supernumerary Limb-inducing Capacity in Tissues of <i>Rana pipiens</i>

Bm¹

1971

Oncology

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The object of this experiment was to determine the anatomical distribution of a supernumerary limb-inducing factor in the tissues of adult Rana pipiens. One mm3 pieces of frog tissues (esophagus, stomach, duodenum, colon, ovary, oviduct, lung, spleen, fat body, cardiac muscle, brain, skeletal muscle, peripheral nerve, skin and tarsal phalanges) were implanted subcutaneously in 252 upper arms of newts (Triturus viridescens). Results of these and previous experiments show that tissue from the lung and the urinary tract possess the greatest ability to induce supernumerary limbs. This ability is moderately present in tissues of the digestive tract, the female genital tract and in skeletal tissues. It is absent in brain, skeletal and cardiac muscle, skin, peripheral nerves and liver.

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The effects of implanting anuran cancer into non‐regenerating and regenerating larval urodele limbs

Cited by 36 publications

References 19 publications

Neoplasia in Poikilotherms

Neoplasia in Poikilotherms

Accessory limb production by nerve‐induced cell proliferation

The Distribution of Supernumerary Limb-inducing Capacity in Tissues of <i>Rana pipiens</i>

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