The effects of ibuprofen on activated sludge: Shift in bacterial community structure and resistance to ciprofloxacin

Dâvids, Madars; Gudrā, Dita; Radoviča-Spalviņa, Ilze; Fridmanis, Dāvids; Bartkevičs, Vadims; Muter, Olga

doi:10.1016/j.jhazmat.2017.06.065

Cited by 37 publications

(20 citation statements)

References 48 publications

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“…Subsequent rapid depletion of ibuprofen following refeeding irrespective of the initial concentration suggests a rapid enrichment of microbes capable of ibuprofen degradation and thus adaption of the microbial community ( Figure 1A-D). A similar pattern was reported in a recent study [47], where an activated sludge microbial community adapted to high concentrations of ibuprofen (5000 mg L −1 ; 24 mM) after long-term exposure, suggesting a rather high limit for ibuprofen tolerance.…”

Section: Biodegradation Of Ibuprofen In the Hyporheic Zone Sedimentssupporting

confidence: 89%

“…The higher degradation rates with subsequent ibuprofen addition (after initial lag; Figure 1), concurrent with the high 16S rRNA gene/transcript abundance ratio in amended relative to unamended sediment samples ( Figure 5), suggested that members of these phyla were enriched and dominated the degrader population. Previously, Proteobacteria and Bacteroidetes were observed in studies on a subsurface flow-constructed wetland system treating ibuprofen-contaminated wastewater, and in oxic ibuprofen-amended microcosms with activated sludge [6,47], indicating the presence and response to ibuprofen of members belonging to these key phyla in diverse environments. Proteobacteria were the most responsive to high ibuprofen concentrations ( Figure 4 and Davids et al [47]).…”

Section: Generalized Ecological Niches Of Ibuprofen-responsive Phylamentioning

confidence: 96%

“…Previously, Proteobacteria and Bacteroidetes were observed in studies on a subsurface flow-constructed wetland system treating ibuprofen-contaminated wastewater, and in oxic ibuprofen-amended microcosms with activated sludge [6,47], indicating the presence and response to ibuprofen of members belonging to these key phyla in diverse environments. Proteobacteria were the most responsive to high ibuprofen concentrations ( Figure 4 and Davids et al [47]). Their response may be attributed to their general functional traits as aromatic compound degraders and the capability to quickly respond to substrate availability [55,56].…”

Section: Generalized Ecological Niches Of Ibuprofen-responsive Phylamentioning

confidence: 96%

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Ibuprofen Degradation and Associated Bacterial Communities in Hyporheic Zone Sediments

et al. 2020

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Ibuprofen, a non-steroidal anti-inflammatory pain reliever, is among pharmaceutical residues of environmental concern ubiquitously detected in wastewater effluents and receiving rivers. Thus, ibuprofen removal potentials and associated bacteria in the hyporheic zone sediments of an impacted river were investigated. Microbially mediated ibuprofen degradation was determined in oxic sediment microcosms amended with ibuprofen (5, 40, 200, and 400 µM), or ibuprofen and acetate, relative to an un-amended control. Ibuprofen was removed by the original sediment microbial community as well as in ibuprofen-enrichments obtained by re-feeding of ibuprofen. Here, 1-, 2-, 3-hydroxy- and carboxy-ibuprofen were the primary transformation products. Quantitative real-time PCR analysis revealed a significantly higher 16S rRNA abundance in ibuprofen-amended relative to un-amended incubations. Time-resolved microbial community dynamics evaluated by 16S rRNA gene and 16S rRNA analyses revealed many new ibuprofen responsive taxa of the Acidobacteria, Actinobacteria, Bacteroidetes, Gemmatimonadetes, Latescibacteria, and Proteobacteria. Two ibuprofen-degrading strains belonging to the genera Novosphingobium and Pseudomonas were isolated from the ibuprofen-enriched sediments, consuming 400 and 300 µM ibuprofen within three and eight days, respectively. The collective results indicated that the hyporheic zone sediments sustain an efficient biotic (micro-)pollutant degradation potential, and hitherto unknown microbial diversity associated with such (micro)pollutant removal.

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Section: Biodegradation Of Ibuprofen In the Hyporheic Zone Sedimentssupporting

confidence: 89%

Section: Generalized Ecological Niches Of Ibuprofen-responsive Phylamentioning

confidence: 96%

Section: Generalized Ecological Niches Of Ibuprofen-responsive Phylamentioning

confidence: 96%

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Ibuprofen Degradation and Associated Bacterial Communities in Hyporheic Zone Sediments

et al. 2020

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“…Intergrons, e.g. int1, is one of the mobile genetic element associated with horizontal gene transfer of ARGs (Davids et al, 2017). Boopathy (2017) validated the presence of methicillinresistant Staphylococcus aureus (MRSA), which has been known to cause serious health problems in the United States, in treated wastewater from a rural wastewater treatment plant to be significantly higher than that in raw wastewater.…”

mentioning

confidence: 99%

“…Biological treatment of wastewater is considered as one of the main processes resulting in the generation of ARBs and ARGs. Davids et al (2017) experimented with a set of incubated samples from activated sludge of a municipal WWTP in Latvia spiked with 1,000 mg/L of ibuprofen over 21 days and proved that ciprofloxacin-resistant bacteria in the samples increased. One of the pathogenic bacteria, Listeria monocytogenes, isolated from constructed wetland ecosystem receiving domestic wastewater was found to be resistant to ciprofloxacin (Calheiros et al, 2017).…”

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confidence: 99%

Fate of Environmental Pollutants

Zad

Astuti

Padhye

2018

Water Environment Research

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This annual review covers the literature published in 2017 on topics related to the occurrence and fate of emerging environmental pollutants in wastewater. Due to the vast amount of literature published on this topic, we have discussed only a portion of the quality research publications, due to the limitation of space. The abstract search was carried out using Web of Science, and the abstracts were selected based on their relevance. In few cases, full-text articles were referred to better understand new findings. This review is divided into the following sections: antibioticresistant bacteria (ARBs) and antibiotic-resistant genes (ARGs), disinfection by-products (DBPs), estrogens, pesticides, pharmaceuticals and personal care products (PPCPs), and microplastics, a new section added this year.

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The effect of caffeine, metronidazole, and ibuprofen on continuous flow activated sludge process

Kanafin

Kakimov

Адамов

et al. 2021

J of Chemical Tech & Biotech

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BACKGROUND The aim of this work was to study the biological treatment of a synthetic wastewater containing emerging contaminants. The 95‐day experiment was conducted in an 81 L continuous flow conventional activated sludge apparatus consisting of anoxic and aerobic reactors with internal recycling, and a clarifier with activated sludge recycling. Real activated sludge from the municipal wastewater treatment plant in the Nur‐Sultan city was used. The degradation efficiencies of caffeine, metronidazole, and ibuprofen in the synthetic wastewater were studied either separately or in combination. RESULTS When treated separately at the concentration of 30 mg/L, the degradation of caffeine and ibuprofen was up to 100%, while the degradation of metronidazole was in the range of 12–27%. Caffeine and ibuprofen inhibited the nitrification process, while the presence of metronidazole in the system suppressed the activity of denitrifying microorganisms. The biological treatment of the synthetic wastewater containing all three compounds (at the concentration of 10 mg/L each) resulted in degradation of caffeine and ibuprofen up to 100%, and 56% in the case of metronidazole. As both nitrification and denitrification processes were affected, the total nitrogen removal was significantly reduced from 53% to 22%. CONCLUSION Complete degradation of caffeine and ibuprofen, and partial degradation of metronidazole were observed in a synthetic wastewater using the activated sludge process. As the presence of emerging pollutants in a wastewater affects the general efficiency of the wastewater treatment plants, other physical or chemical pre‐treatment should be utilized to minimize the harmful effect of contaminants on the biological processes. © 2021 Society of Chemical Industry

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The effects of ibuprofen on activated sludge: Shift in bacterial community structure and resistance to ciprofloxacin

Cited by 37 publications

References 48 publications

Ibuprofen Degradation and Associated Bacterial Communities in Hyporheic Zone Sediments

Ibuprofen Degradation and Associated Bacterial Communities in Hyporheic Zone Sediments

Fate of Environmental Pollutants

The effect of caffeine, metronidazole, and ibuprofen on continuous flow activated sludge process

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