The Effects of Sophorae Radix Pharmacopuncture Therapy on the Chunchu(ST₂₅) for DSS-induced Colitis in Rats

Abstract

Objectives : The purpose of this study is to investigate the effects of Sophorae radix pharmacopuncture(SRP) therapy on the Chunchu(ST25) on intestinal disease in rats with dextran sulfate sodium(DSS)-induced colitis. Methods : The experimental model of colitis was induced by an infection of DSS for fifteen days. After colitis was induced, SRP therapy was practiced on the Chunchu(ST25) once every three days for a total of five times. Afterward, colon length, damage to the colonic mucosa, complete blood count, aspartate aminotransferase(AST), alanine transferase(ALT), blood urea nitrogen(BUN), creatinine, TNF-α and IL-6 were measured. Results : The results were obtained as below. 1. Colon length was significantly increased in the SRP group 2 compared to the control group. 2. Damage of colonic mucosa was observed less in the SRP groups than in the other groups. 3. The mean rates of white blood cell(WBC), neutrophils and lymphocytes were significantly increased in SRP group 2 compared to the control group. 4. The mean rates of HGB and hematocrit(HCT) were significantly increased in the SRP compared to the control group. 5. No significant differences were shown in AST, ALT, BUN and Creatinine between the SRP groups and the control group. 6. The mean rate of TNF-α was significantly decreased in the SRP groups compared to the control group. 7. The mean of IL-6 was significantly decreased in the SRP groups compared to the control group. Conclusions : These results indicated that SRP therapy on Chunchu(ST25) functions as a treatment to the dextran sulfate sodium-induced colitis.

The Effects of Pulsatilla Koreana NAKAI Pharmacopuncture Therapy on the Chunchu (ST25) for Dextran Sulfate Sodium-Induced Colitis in Mice

“…In the study of Yang et al [12], which applied the Sophorae Radix Pharmacopuncture Therapy to Chunchu (ST25), and the study of Lee et al [38], which applied the Hwangnyeonhaedoktang Pharmacopuncture to Chunchu (ST25), the changes in length and weight of the colon were significant, and it was judged that Chunchu (ST25) itself had a stimulating effect as well as the effect of the pharmacopuncture itself.…”

“…Studies on Korean medicine have been proceeded and reported by the method of Korean medicine, and studies using medicinal prescriptions such as Soyumjungjang-tang [5], Jiyutang [6], Hwangryunhaedoktang [7] and studies using prescription of single herb such as Auklandia Lappa [8], Mume Fructus [9], Orostachys japonicas [10]. On the other hand, there are only a handful of studies that have applied acupuncture and pharmacopuncture such as Five Transport Points of the Spleen Meridian [11], Sophorae Radix Pharmacopuncture [12].…”