The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　― First Pilot Study in Humans ―

Katsumata, Yoshinori; Sano, Fumiya; Abe, Takayuki; Tamura, Tomoyoshi; Fujisawa, Taishi; Shiraishi, Yasuyuki; Kohsaka, Shun; Ueda, Ikuko; Homma, Koichiro; Suzuki, Mitsuaki; Okuda, S.; Maekawa, Yuichiro; Kobayashi, Eiji; Hori, Shingo; Sasaki, Junichi; Fukuda, Keiichi; Sano, Motoaki

doi:10.1253/circj.cj-17-0105

Cited by 66 publications

(71 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found that inhalation of hydrogen gas did not reduce the infarct size during the acute phase of MI. However, comparison of cardiac magnetic resonance imaging data obtained 1 week and 6 months after MI showed no change or a decrease in left ventricular stroke volume in the control group, whereas it was increased in the hydrogen gas inhalation group 4. This suggested that inhalation of hydrogen gas during the acute phase of MI suppressed adverse left ventricular remodeling at 6 months after infarction.…”

Section: Clinical Evidencementioning

confidence: 88%

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Sano

Suzuki

Homma

et al. 2017

Acute Medicine & Surgery

Self Cite

View full text Add to dashboard Cite

It has been reported that hydrogen gas exerts a therapeutic effect in a wide range of disease conditions, from acute illness such as ischemia–reperfusion injury, shock, and damage healing to chronic illness such as metabolic syndrome, rheumatoid arthritis, and neurodegenerative diseases. Antioxidant and anti‐inflammatory properties of hydrogen gas have been proposed, but the molecular target of hydrogen gas has not been identified. We established the Center for Molecular Hydrogen Medicine to promote non‐clinical and clinical research on the medical use of hydrogen gas through industry–university collaboration and to obtain regulatory approval of hydrogen gas and hydrogen medical devices (http://www.karc.keio.ac.jp/center/center-55.html). Studies undertaken by the Center have suggested possible therapeutic effects of hydrogen gas in relation to various aspects of emergency and critical care medicine, including acute myocardial infarction, cardiopulmonary arrest syndrome, contrast‐induced acute kidney injury, and hemorrhagic shock.

show abstract

Section: Clinical Evidencementioning

confidence: 88%

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Sano

Suzuki

Homma

et al. 2017

Acute Medicine & Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…While it has been shown that hydrogen gas is effective for preventing ischemia reperfusion injury [1][2][3][4], hydrogen gas is flammable at high concentrations and clinical use is limited by safety considerations. Our previous investigator-initiated clinical trial demonstrated that inhalation of hydrogen gas combined with coronary intervention could inhibit left ventricular remodeling after myocardial infarction [30]. In that trial, the subjects inhaled a gas mixture of hydrogen (1.3%), oxygen, and nitrogen.…”

Section: Discussionmentioning

confidence: 99%

Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs

Kobayashi

Sano

2019

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Various methods have been devised to dissolve hydrogen gas in organ preservation solutions, including use of a hydrogen gas cylinder, electrolysis, or a hydrogen-generating agent. However, these methods require considerable time and effort for preparation. We investigated a practical technique for rapidly dissolving hydrogen gas in organ preservation solutions by using a canister containing hydrogen-absorbing alloy. The efficacy of hydrogen-containing organ preservation solution created by this method was tested in a miniature pig model of kidney transplantation from donors with circulatory arrest. The time required for dissolution of hydrogen gas was only 2-3 minutes. When hydrogen gas was infused into a bag containing cold ETK organ preservation solution at a pressure of 0.06 MPa and the bag was subsequently opened to the air, the dissolved hydrogen concentration remained at 1.0 mg/L or more for 4 hours. After warm ischemic injury was induced by circulatory arrest for 30 minutes, donor kidneys were harvested and perfused for 5 minutes with hydrogen-containing cold ETK solution or hydrogen-free cold ETK solution. The perfusion rate was faster from the initial stage with hydrogen-containing cold ETK solution than with hydrogen-free ETK solution. After storage of the kidney in hydrogen-free preservation solution for 1 hour before transplantation, no urine production was observed and blood flow was not detected in the transplanted kidney at sacrifice on postoperative day 6. In contrast, after storage in hydrogen-containing preservation solution for either 1 or 4 hours, urine was detected in the bladder and blood flow was confirmed in the transplanted kidney. This method of dissolving hydrogen gas in organ preservation solution is a practical technique for potentially converting damaged organs to transplantable organs that can be used safely in any clinical setting where organs are removed from donors.

show abstract

“…However, the approximately 60 studies in humans published so far strengthen inhalation of hydrogen gas is being clinically investigated in post-cardiac arrest patients in a large 360-patient multi-centered study with promising preliminary results (Ono et al 2017). Animal studies suggest that H 2 inhalation may be more effective than conventional hypothermia at mitigating the ischemia/reperfusion injury following cardiac resuscitation (Katsumata et al 2017). Table 2 summarizes the known studies on hydrogen administration and exercise in humans and animals, illustrating hydrogen's potential benefit in exercise medicine and sports performance.…”

Section: Human Studies With H 2 Administrationmentioning

confidence: 99%

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes

LeBaron

Laher

Kura

et al. 2019

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

H2 has been clinically demonstrated to provide antioxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i.e., noxious exercise) in untrained individuals, result in similar pathological factors such as inflammation, oxidation, and cellular damage that arise from and result in disease. Paradoxically, exercise-induced pro-inflammatory cytokines and reactive oxygen species largely mediate the benefits of exercise. Ingestion of conventional antioxidants and anti-inflammatories often impairs exercise-induced training adaptations. Disease and noxious forms of exercise promote redox dysregulation and chronic inflammation, changes that are mitigated by H2 administration. Beneficial exercise and H2 administration promote cytoprotective hormesis, mitochondrial biogenesis, ATP production, increased NAD+/NADH ratio, cytoprotective phase II enzymes, heat-shock proteins, sirtuins, etc. We review the biomedical effects of exercise and those of H2, and we propose that hydrogen may act as an exercise mimetic and redox adaptogen, potentiate the benefits from beneficial exercise, and reduce the harm from noxious exercise. However, more research is warranted to elucidate the potential ergogenic and therapeutic effects of H2 in exercise medicine.

show abstract

The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　― First Pilot Study in Humans ―

Abstract: The first clinical study has shown that HI during PCI is feasible and safe and may also promote LV reverse remodeling at 6 months after STEMI. The study was not powered to test efficacy and a further large-scale trial is warranted. (Clinical trials registration: UMIN00006825).

Cited by 66 publications

References 28 publications

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes

Contact Info

Product

Resources

About

The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction ― First Pilot Study in Humans ―

Abstract: The first clinical study has shown that HI during PCI is feasible and safe and may also promote LV reverse remodeling at 6 months after STEMI. The study was not powered to test efficacy and a further large-scale trial is warranted. (Clinical trials registration: UMIN00006825).

Cited by 66 publications

References 28 publications

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes

Contact Info

Product

Resources

About

The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　― First Pilot Study in Humans ―