The Effects of Human Hippocampal Resection on the Serial Position Curve

Hermann, Bruce P.; Seidenberg, Michael; Wyler, Allen R.; Davies, Keith G.; Christeson, Jennifer; Morán, María Teresa Cabero; Stroup, Elizabeth

doi:10.1016/s0010-9452(96)80054-2

Cited by 48 publications

(43 citation statements)

References 21 publications

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“…By contrast to the current behavioral data, medial temporal lobe epilepsy patients performing the same task do not demonstrate enhanced memory for initial list items (Fernandez et al, 1999), which is in line with previous observations of absent primacy in hippocampal-lesioned patients (Jones-Gotman, 1986;Hermann et al, 1996). Given that these patients have medial temporal damage, we hypothesized that the primacy effect may have a discrete neuronal substrate in the medial temporal lobe.…”

Section: Functional Imagingsupporting

confidence: 82%

Dissociable Human Perirhinal, Hippocampal, and Parahippocampal Roles during Verbal Encoding

Strange¹,

Otten²,

Josephs³

et al. 2002

J. Neurosci.

213

149

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The precise contribution of perirhinal cortex to human episodic memory is uncertain. Human intracranial recordings highlight a role in successful episodic memory encoding, but encodingrelated perirhinal activation has not been observed with functional imaging. By adapting functional magnetic resonance imaging scanning parameters to maximize sensitivity to medial temporal lobe activity, we demonstrate that left perirhinal and hippocampal responses during word list encoding are greater for subsequently recalled than forgotten words. Although perirhinal responses predict memory for all words, successful encoding of initial words in a list, demonstrating a primacy effect, is associated with parahippocampal and anterior hippocampal activation. We conclude that perirhinal cortex and hippocampus participate in successful memory encoding. Encoding-related parahippocampal and anterior hippocampal responses for initial, remembered words most likely reflects enhanced attentional orienting to these positionally distinctive items.

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Section: Functional Imagingsupporting

confidence: 82%

Dissociable Human Perirhinal, Hippocampal, and Parahippocampal Roles during Verbal Encoding

Strange¹,

Otten²,

Josephs³

et al. 2002

J. Neurosci.

213

149

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“…That is, AD showed relatively better recall of the final words in the list. This is consistent with the fact that patients with temporal lobe lesions also show a recency effect on word list learning (Hermann et al, 1996), but no FTD patients were included in the Tierney et al studies for comparison. Serial position effects have been examined in just one previous study of the RAVLT that included both AD and FTD patients (Ranjith et al, 2010).…”

Section: Using Ravlt To Differentiate Dementias 927supporting

confidence: 67%

Using the Rey Auditory Verbal Learning Test (RAVLT) to Differentiate Alzheimer's Dementia and Behavioural Variant Fronto-Temporal Dementia

Ricci¹,

Graef²,

Blundo³

et al. 2012

The Clinical Neuropsychologist

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In patients with focal lesions, patterns of learning, retrieval, and recognition deficits vary according to site of damage. Because different brain regions are affected by the underlying pathology in Alzheimer's dementia (AD) and behavioral variant fronto-temporal dementia (bvFTD), one might predict that the two disorders would result in different sorts of memory deficits on the Rey Auditory Verbal Learning Test (RAVLT). The aim of this investigation was to find a way to differentiate AD, bvFTD, and normal controls (NC) reliably based on RAVLT scores from retrospective samples of 82 Italian and 43 Australian participants. Results indicated that the groups differed on measures of learning, retroactive interference, delayed recall, and delayed recognition. Although delayed recall distinguished participants in the three groups across both samples, no one set of cut-offs could be obtained with adequate sensitivity and specificity. However, when we created a combined score (the "RAVLT Memory Efficiency Index": {[(delayed recall A/15)/(RAVLT Trials 1-5/75)] + [(delayed recognition hits/15) - (false positive/total number of distractors)]}), we were able to find cut-offs that differentiated the groups with good sensitivity and specificity across variations in RAVLT methodology, participant samples, and languages. This index will increase the usefulness of the RAVLT in differential diagnoses of early dementia.

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“…Jones-Gotman (1986) showed that performance was related to the extent of the damage to the right hippocampus in memory for visual materials. Hermann et al (1996) showed that memory for verbal materials was more affected by the lobectomy in patients who did not have hippocampal sclerosis in the left hippocampus, suggesting that the non-sclerotic hippocampus was contributing to recall of pre-recency items prior to the operation. Lesion studies in rats also support the view that memory for the early and middle items in a list depends on an intact hippocampus (Kesner, Crutcher, & Beers, 1988;Kesner & Novak, 1982).…”

Section: The Context T a Imentioning

confidence: 99%

“…Murray and Mishkin (1998), showed that lesions to the amygdala and hippocampus that spared rhinal cortex did not have an effect on DNMS performance, whereas a comparable study showed a severe impairment from rhinal cortex lesions at delays as short as tens of seconds (Meunier, Bachevalier, Mishkin, & Murray, 1993 The first suggestion comes from the finding that hippocampal damage is associated with a disruption of memory for items from the early part of the serial position curve. Studies of epileptic patients who received anterior temporal lobectomies that included hippocampal resection show a deficit in memory that is largest for items from early and middle serial positions (Hermann, Seidenberg, Wyler, et al, 1996;Jones-Gotman, 1986). These studies both suggested that damage to the hippocampus itself was responsible for the deficit.…”

Section: The Context T a Imentioning

confidence: 99%

The Temporal Context Model in Spatial Navigation and Relational Learning: Toward a Common Explanation of Medial Temporal Lobe Function Across Domains.

Howard¹,

Fotedar²,

Datey³

et al. 2005

Psychological Review

272

334

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The medial temporal lobe (MTL) has been studied extensively at all levels of analysis, yet its function remains unclear. Theory regarding the cognitive function of the MTL has centered along 3 themes. Different authors have emphasized the role of the MTL in episodic recall, spatial navigation, or relational memory. Starting with the temporal context model (M. W. Howard and M. J. , a distributed memory model that has been applied to benchmark data from episodic recall tasks, the authors propose that the entorhinal cortex supports a gradually changing representation of temporal context and the hippocampus proper enables retrieval of these contextual states. Simulation studies show this hypothesis explains the firing of place cells in the entorhinal cortex and the behavioral effects of hippocampal lesion in relational memory tasks. These results constitute a first step towards a unified computational theory of MTL function that integrates neurophysiological, neuropsychological and cognitive findings.The medial temporal lobe (MTL) is a region that includes the hippocampus proper, the subicular complex and parahippocampal cortical regions, including entorhinal, perirhinal, and parahippocampal/postrhinal cortices. A great deal of data from neuropsychology (e.g. Eichenbaum & Cohen, 2001;Scoville & Milner, 1957;Squire, 1992) and functional imaging (e.g. Fernandez, Effern, Grunwald, et al., 1999;Stern, Corkin, Gonzalez, et al., 1996;Wagner et al., 1998) has converged on the idea that the MTL is important in learning and memory. In order to bridge the gap between cognition and cellular-level physiology, we need a mechanistic, mesoscopic description of MTL computational function. We already have several successful verbally-formulated theories of the cognitive function of the MTL. These are described in turn in the following subsections. This paper will attempt to draw these multiple verbal theories together into a single computational framework that is consistent with known neurophysiological and neuroanatomical data.

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The Effects of Human Hippocampal Resection on the Serial Position Curve

Cited by 48 publications

References 21 publications

Dissociable Human Perirhinal, Hippocampal, and Parahippocampal Roles during Verbal Encoding

Dissociable Human Perirhinal, Hippocampal, and Parahippocampal Roles during Verbal Encoding

Using the Rey Auditory Verbal Learning Test (RAVLT) to Differentiate Alzheimer's Dementia and Behavioural Variant Fronto-Temporal Dementia

The Temporal Context Model in Spatial Navigation and Relational Learning: Toward a Common Explanation of Medial Temporal Lobe Function Across Domains.

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