The effects of hormone therapy on pulmonary function tests in postmenopausal women

Cevrioğlu, Arif Serhan; Fidan, Fatma; Ünlü, Mehmet; Yılmazer, Mehmet; Orman, Ayşe; Fenkci, Ibrahim Veysel; Serteser, Mustafa

doi:10.1016/j.maturitas.2004.01.009

Cited by 40 publications

(34 citation statements)

References 29 publications

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“…However, the exact mechanisms involved in lower lung function in postmenopausal women of the present study cannot be elucidated from this type of study. According to the suggestions made by different investigators, 8,9 lower percentages of predicted values of FVC and FEV 1 , PEFR, and FEF 25-75 in postmenopausal women in comparison to premenopausal women during follicular and luteal phase are most likely due to decreased level of progesterone and estrogen as observed in this study. Reduced levels of estrogen and progesterone would cause decreased muscular strength, decreased relaxation of bronchial smooth muscle, and increased compression of thoracic spine and as a result there is reduced total lung capacity.…”

supporting

confidence: 65%

“…In postmenopausal women, relationship between low level of estrogen and progesterone and the changes in FEF and PEFR has been explored by several investigators of different countries. [8][9][10] In this study, mean percentage of predicted values of FEF 25-75 and PEFR was lower in postmenopausal women. Various mechanisms have been proposed for these observed changes in lung function in postmenopausal women.…”

Section: Discussionmentioning

confidence: 81%

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Effect of Menopause on Pulmonary Functions: An Analysis

Karia¹,

Kedar²,

Munje³

2017

Journal of SAFOMS

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Background: Sex hormones play an important role in women's health. There is a close relationship between female sex hormones and lung function in postmenopausal women. Deterioration of lung function is observed more after menopause. Estrogen deficiency after menopause accelerates adverse effects of biological aging on lung mechanics in postmenopausal women. Our study uses spirometer to analyze and evaluate these effects of menopausal aging.

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supporting

confidence: 65%

Section: Discussionmentioning

confidence: 81%

Effect of Menopause on Pulmonary Functions: An Analysis

Karia¹,

Kedar²,

Munje³

2017

Journal of SAFOMS

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“…The standardized mortality rate is almost twice higher in women than men among individuals with COPD who participated in a survey in which the average age upon entry was 56.6 yr (27). Thus evidence is growing to indicate estrogen may delay the loss of, and improve, those lung functions that reflect maintenance of alveolar structure (3,4,13,25,30) and, as a consequence, the number of alveolar attachments to small conducting airways.…”

Section: Discussionmentioning

confidence: 99%

Estrogen receptor regulation of pulmonary alveolar dimensions: alveolar sexual dimorphism in mice

Massaro¹,

Massaro²

2006

American Journal of Physiology-Lung Cellular and Molecular Phys

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, more alveoli and alveolar surface area (Sa) than males of their respective species. This sexual dimorphism becomes apparent about the time of sexual maturity. It is prevented in rats (not tested in mice) by ovariectomy at age 3 wk. In female mice, estrogen receptor (ER)-␣ and ER-␤ are required for formation of alveoli of appropriate size and number. We now report the average volume of an alveolus (v a) and the number of alveoli per body mass (Na/BM) were not statistically different between ER-␣

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“…The most obvious factor would be oestrogen-related, and several studies have shown that post-menopausal women who use hormone replacement therapy (HRT) experience less pulmonary function decline and less inflammation than older women who do not take exogenous hormones. 31,[48][49][50] In the Cardiovascular Health Study, spirometry was performed on 2,353 women older than 65 years who could provide information on HRT use. FEV 1 was higher overall in women who were currently using HRT than in those who were not currently using HRT (1.82 L vs. 1.66 L, p<0.0001), including former smokers (currently using versus not currently using HRT: 1.76 L vs. 1.60 L, p=0.013) and never smokers (1.90 L vs. 1.72 L, p<0.0001).…”

Section: Susceptibilitymentioning

confidence: 99%

Reconsidering sex-based stereotypes of COPD

Ohar

Fromer

Donohue

2011

Primary Care Respiratory Journal

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Chronic obstructive pulmonary disease (COPD) has historically been considered a disease of older, white, male smokers, as illustrated in Frank Netter's classic images of the 'pink puffer' and 'blue bloater'. However, women may be more susceptible to COPD than men, and the disease course may be reflective of that increased susceptibility. From a review of epidemiological data of COPD, we found differences in the way men and women present with COPD symptoms, a bias in the way COPD symptoms are treated in men and women, and differences in susceptibility to airway obstruction based on age, sex, and smoking history. These data show that classic stereotypes of COPD -including male predominance -should be abandoned, and that there are not two but multiple COPD phenotypes, which are characterised by differences between women and men in susceptibility, symptoms, and disease progression. These differences impact on physician perception. Although further research into this concept is needed, the differences we found should prompt, in the short term, changes in the way (and in whom) COPD is evaluated, diagnosed, and treated; in the long term, these differences should prompt research into the prognosis of COPD based on sex differences.

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The effects of hormone therapy on pulmonary function tests in postmenopausal women

Cited by 40 publications

References 29 publications

Effect of Menopause on Pulmonary Functions: An Analysis

Effect of Menopause on Pulmonary Functions: An Analysis

Estrogen receptor regulation of pulmonary alveolar dimensions: alveolar sexual dimorphism in mice

Reconsidering sex-based stereotypes of COPD

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